scholarly journals ĐẶC ĐIỂM CỦA BỆNH NHÂN ĐA U TỦY CÓ KHUẾCH ĐẠI 1q21 TẠI BỆNH VIỆN TRUYỀN MÁU HUYẾT HỌC

2021 ◽  
Vol 505 (2) ◽  
Author(s):  
Trần Thùy Anh ◽  
Phạm Kim Thạnh ◽  
Nguyễn Tấn Bỉnh ◽  
Phan Thị Xinh
Keyword(s):  
Beta 2 ◽  
Beta 2 Microglobulin

Mục tiêu: Mô tả đặc điểm lâm sàng, xét nghiệm lúc chẩn đoán và đặc điểm di truyền của bệnh nhân đa u tủy có khuếch đại NST 1q. Phương pháp nghiên cứu: Nghiên cứu hồi cứu cắt ngang mô tả hàng loạt ca. Đối tượng: 95 bệnh nhân đa u tủy mới chẩn đoán tại bệnh viện truyền máu huyết học thỏa tiêu chuẩn chọn mẫu trong khoảng thời gian từ 1/2017 đến 12/2020. Kết quả và bàn luận: Tỉ lệ bệnh nhân mang khuếch đại NST 1q là 29,5% (n = 28). Trong số các bất thường về lâm sàng, triệu chứng thiếu máu và đau nhức xương thường gặp nhất (> 70%), ngoài ra còn có triệu chứng u tương bào, sụt cân, sốt, xuất huyết, không có sự khác biệt giữa 2 nhóm có và không có khuếch đại 1q. Tăng calci máu, tăng Beta-2-microglobulin, giai đoạn bệnh muộn, nhiều bất thường di truyền và bất thường thuộc nhóm nguy cơ cao là những đặc điểm khác biệt đáng kể giữa 2 nhóm nghiên cứu (p < 0.05). Kết luận: Có sự khác biệt về các đặc điểm sinh học của nhóm bệnh nhân có khuếch đại NST 1q, cho thấy nhóm BN nay thuộc nhóm nguy cơ cao.

Serial Quantification of Urinary Protein Biomarkers to Predict Drug-induced Acute Kidney Injury

2019 ◽  
Vol 20 (8) ◽  
pp. 656-664 ◽  
Author(s):  
Yi Da ◽  
K. Akalya ◽  
Tanusya Murali ◽  
Anantharaman Vathsala ◽  
Chuen-Seng Tan ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cystatin C ◽  
Calcineurin Inhibitors ◽  
Kidney Injury ◽  
Tubular Dysfunction ◽  
Renal Tubular Dysfunction ◽  
Protein Biomarkers ◽  
Drug Induced ◽  
Beta 2 ◽  
Beta 2 Microglobulin

Background: : Drug-induced Acute Kidney Injury (AKI) develops in 10-15% of patients who receive nephrotoxic medications. Urinary biomarkers of renal tubular dysfunction may detect nephrotoxicity early and predict AKI. Methods:: We prospectively studied patients who received aminoglycosides, vancomycin, amphotericin, or calcineurin inhibitors, and collected their serial urine while on therapy. Patients who developed drug-induced AKI (fulfilling KDIGO criteria) were matched with non-AKI controls in a 1:2 ratio. Their urine samples were batch-analyzed at time-intervals leading up to AKI onset; the latter benchmarked against the final day of nephrotoxic therapy in non- AKI controls. Biomarkers examined include clusterin, beta-2-microglobulin, KIM1, MCP1, cystatin-C, trefoil-factor- 3, NGAL, interleukin-18, GST-Pi, calbindin, and osteopontin; biomarkers were normalized with corresponding urine creatinine. Results:: Nine of 84 (11%) patients developed drug-induced AKI. Biomarkers from 7 AKI cases with pre-AKI samples were compared with those from 14 non-AKI controls. Corresponding mean ages were 55(±17) and 52(±16) years; baseline eGFR were 99(±21) and 101(±24) mL/min/1.73m2 (all p=NS). Most biomarker levels peaked before the onset of AKI. Median levels of 5 biomarkers were significantly higher in AKI cases than controls at 1-3 days before AKI onset (all µg/mmol): clusterin [58(8-411) versus 7(3-17)], beta-2-microglobulin [1632(913-3823) versus 253(61-791)], KIM1 [0.16(0.13-0.76) versus 0.07(0.05-0.15)], MCP1 [0.40(0.16-1.90) versus 0.07(0.04-0.17)], and cystatin-C [33(27-2990) versus 11(7-19)], all p<0.05; their AUROC for AKI prediction were >0.80 (confidence intervals >0.50), with average accuracy highest for clusterin (86%), followed by beta-2-microglobulin, cystatin-C, MCP1, and KIM1 (57%) after cross-validation. Conclusion: : Serial surveillance of these biomarkers could improve the lead time for nephrotoxicity detection by days.

Theiler's virus infection of beta 2-microglobulin-deficient mice.

1993 ◽  
Vol 67 (1) ◽  
pp. 589-592 ◽  
Author(s):  
L Fiette ◽  
C Aubert ◽  
M Brahic ◽  
C P Rossi
Keyword(s):  
Virus Infection ◽  
Theiler's Virus ◽  
Beta 2 ◽  
Beta 2 Microglobulin ◽  
Deficient Mice

Time-resolved fluoroimmunoassay of beta 2-microglobulin in serum and cerebrospinal fluid

1993 ◽  
Vol 39 (3) ◽  
pp. 552-553 ◽  
Author(s):  
D Meillet ◽  
L Bélec ◽  
E Schuller ◽  
J Delattre
Keyword(s):  
Cerebrospinal Fluid ◽  
Time Resolved ◽  
Beta 2 ◽  
Beta 2 Microglobulin

Evaluation of beta-2 microglobulin, erythropoietin and tobacco use in polycythemic cases

2021 ◽  
Author(s):  
Kristell Mahe ◽  
Francis Couturaud ◽  
Hélène Kerspern ◽  
Aurélie Chauveau ◽  
Jean-Christophe Ianotto
Keyword(s):  
Tobacco Use ◽  
Beta 2 ◽  
Beta 2 Microglobulin

scholarly journals Renal Involvement in Children with Type 2 Diabetes Mellitus Onset: A Pilot Study

Children ◽  
2021 ◽  
Vol 8 (8) ◽  
pp. 627
Author(s):  
Pierluigi Marzuillo ◽  
Anna Di Sessa ◽  
Pier Luigi Palma ◽  
Giuseppina Rosaria Umano ◽  
Cesare Polito ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Renal Involvement ◽  
Kidney Injury ◽  
Fractional Excretion ◽  
Tubular Damage ◽  
Beta 2 ◽  
Beta 2 Microglobulin

Type 2 Diabetes Mellitus (T2DM) is a main cause of chronic kidney disease (CKD) in adulthood. No studies have examined the occurrence of acute kidney injury (AKI)—that enhances the risk of later CKD—and renal tubular damage (RTD)—that can evolve to AKI—in children with onset of T2DM. We aimed to evaluate the prevalence and possible features of AKI and RTD in a prospectively enrolled population of children with onset of T2DM. We consecutively enrolled 10 children aged 12.9 ± 2.3 years with newly diagnosed T2DM. AKI was defined according to the KDIGO criteria. RTD was defined by abnormal urinary beta-2-microglobulin and/or tubular reabsorption of phosphate (TRP) < 85% and/or fractional excretion of Na > 2%. None of the patients developed AKI, whereas 3/10 developed RTD with high beta-2-microglobulin levels (range: 0.6–1.06 mg/L). One of these three patients also presented with reduced TRP levels (TRP = 70%). Proteinuria was observed in two out of three patients with RTD, while none of patients without RTD had proteinuria. Patients with RTD presented higher beta-2-microglobulin, acute creatinine/estimated basal creatinine ratio, and serum ketones levels compared with patients without RTD. In conclusion, in our pilot observation, we found that none of the 10 children with T2DM onset developed AKI, whereas three of them developed RTD.

First-week urine beta-2 microglobulin levels in term healthy neonates

2021 ◽  
Author(s):  
Shimrit Tzvi-Behr ◽  
Heftziba Ivgi ◽  
Yaacov Frishberg ◽  
Efrat Ben Shalom
Keyword(s):  
Beta 2 ◽  
Beta 2 Microglobulin
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