Design and Validation of UV Spectrophotometric Method for Estimation and the Routine Quality Control Analysis of Sildenafil Citrate in Bulk and in Tablet Formulations

2021 ◽  
Vol 1 (2) ◽  
pp. 40
Author(s):  
Fatehalrahman F. Magbool ◽  
Abdrhman Mahmoud Gamil ◽  
Mahmoud A. Ibrahim ◽  
Mohamd E. Adam
Keyword(s):  
Quality Control ◽  
Spectrophotometric Method ◽  
Sildenafil Citrate ◽  
Control Analysis ◽  
Quality Control Analysis ◽  
Tablet Formulations ◽  
Routine Quality Control

scholarly journals Estimation of Nortriptyline hydrochloride in Bulk and Formulation by UV-Spectrophotometric Area Under Curve Method

2019 ◽  
Vol 9 (3) ◽  
pp. 147-150
Author(s):  
Suchita R. Abhang ◽  
Shankar M. Dhobale ◽  
Akshada D. Suryawanshi ◽  
Suresh L. Jadhav ◽  
Salim G. Patel
Keyword(s):  
Quality Control ◽  
Present Method ◽  
Area Under Curve ◽  
Dosage Form ◽  
Control Analysis ◽  
Pharmaceutical Dosage Form ◽  
Quality Control Analysis ◽  
Curve Method ◽  
Nortriptyline Hydrochloride ◽  
Routine Quality Control

The simple, precise and accurate UV-Spectrophotometric method has been developed and validated for the estimation of nortriptyline hydrochloride in bulk and dosage form. In that work was carried out for estimation of nortriptyline hydrochloride in bulk and pharmaceutical dosage form by utilizing area under curve (AUC) method. For this purpose the wavelength range 200-400nm was selected. DMSO was used as solvent throughout the work. Linearity was observed in concentration range 5-25µg/ml (R2 =0.996) for the method. The present method was found which can be used for routine quality control analysis for spectrophotometric estimation of Nortriptyline hydrochloride in bulk and dosage form. Keywords: Nortriptyline hydrochloride, Area under curve (AUC), DMSO, UV-Spectrophotometric.

scholarly journals Area Under Curve by UV Spectrophotometric Method for Determination Albendazole in Bulk

2019 ◽  
Vol 9 (6) ◽  
pp. 47-50
Author(s):  
Kedar Vikas Dagdu ◽  
Manoj Gadhave ◽  
Shubham Bhujbal ◽  
Bhushan Shrinath
Keyword(s):  
Spectrophotometric Method ◽  
Area Under Curve ◽  
Active Pharmaceutical Ingredient ◽  
Control Analysis ◽  
Distilled Water ◽  
Quality Control Analysis ◽  
Ich Guidelines ◽  
Highly Sensitive ◽  
Uv Visible ◽  
Routine Quality Control

The aim of present investigation is to establish simple, precise, and rapid Spectrophotometric method for the quantification of Albendazole in Active Pharmaceutical Ingredient. In this, work is carried out to for estimation of Albendazole bulk by utilizing an Area under Curve (AUC) method using UV – Visible Spectrophotometry. The study is designed to validate the developed methods as per ICH guidelines. For this purpose the wavelength range between 200-400 nm was selected. Methanolic distilled water (50 ml methanol used for stock solution and serial dilution in 25 ml distilled water) was used as a solvent throughout the work. Linearity was obtained in concentration range 2 to 10 ɥg/ml (r2 = 0.992) for the method. The developed method was found to be simple, linear, accurate, precise and highly sensitive and which can be used for routine quality control analysis for Spectrophotometric estimation of Active Pharmaceutical Ingredient. KeywordS: Albendazole, linearity, AUC, spectrophotometer, methanol, distilled water.

scholarly journals Development and Validation of a Stability-Indicating Method for the Determination of Pazopanib Hydrochloride by RP-HPLC

2021 ◽  
Vol 68 (1) ◽  
Author(s):  
Ravisankar P. ◽  
M. Nithya Satya ◽  
A. Bhavani Sailu ◽  
Sk. Rijwana ◽  
K. Harsha Sri ◽  
...  
Keyword(s):  
Quality Control ◽  
Thermal Conditions ◽  
Hplc Method ◽  
Control Analysis ◽  
Pharmaceutical Tablets ◽  
Stability Indicating Method ◽  
Quality Control Analysis ◽  
Rp Hplc ◽  
Tablet Dosage ◽  
Routine Quality Control

A precise, accurate, highly sensitive, rapid, and reproducible stability HPLC method was developed and validated for the estimation of Pazopanib Hydrochloride (PAZO) in bulk and tablet dosage form. Decent quality chromatographic separation of Pazopanib Hydrochloride was done by using Eclipse plus C18 column (4.5 mm i.e. X 150 mm, 3.5µm particle size) (based on 99.99 % ultra-high purity silica) using mobile phase that containing 0.1 % Orthophosphoric acid: Acetonitrile (55:45 % v\v) at a flow rate of 1.0 mL/minute. The wavelength ?max of PAZO used for the detection was found to be 271.4 nm. The retention time for Pazopanib was found to 1.43 minutes. The PAZO was linear in the concentration range of 2-10 µg/mL (r2 = 0.9999) for HPLC method. The regression equation for PAZO was found to be Y = 700955 x + 28022 for HPLC. The LOD and LOQ were found to be 0.1675 ?g/mL, 0.0552 µg/mL for the HPLC method, respectively. The developed methods are validated in pursuance of ICH Q2 (R1) guidelines. The method was linear, precise, accurate with recoveries in the range of 98 – 102 %, and minimum values of % RSD indicate the accuracy of the method. The % assay of the PAZO was found to be 99.85 ± 1.2, which was in good agreement with the labeled claim. Pazopanib was subjected to stressed conditions like acidic, basic, oxidative, photolytic, and thermal conditions. The degradation results were found satisfactory. The developed gradient RP-HPLC method can be successfully practiced for the routine quality control analysis of PAZO in pharmaceutical tablets and routine quality control analysis.

scholarly journals Development, Estimation and Validation of Lisinopril in Bulk and its Pharmaceutical Formulation by HPLC Method

2012 ◽  
Vol 9 (1) ◽  
pp. 340-344 ◽  
Author(s):  
V. Bhaskara Raju ◽  
A. Lakshmana Rao
Keyword(s):  
Quality Control ◽  
Mobile Phase ◽  
Dosage Forms ◽  
Hplc Method ◽  
Control Analysis ◽  
Reverse Phase ◽  
Quality Control Analysis ◽  
Tablet Dosage ◽  
Routine Quality Control

An accurate and preciseHPLCmethod was developed for the determination of lisinopril. Separation of the drug was achieved on a reverse phase C8column using a mobile phase consisting of phosphate buffer and methanol in the ratio of 35:65v/v. The flow rate was 0.8 mL/min and the detection wavelength was 215 nm. The linearity was observed in the range of 20-60 μ g/mL with a correlation coefficient of 0.9992. The proposed method was validated for its linearity, accuracy, precision and robustness. This method can be employed for routine quality control analysis of lisinopril in tablet dosage forms.

Quality Control Analysis of Safoof-e-Pathar Phori, A Unani Herbo-mineral Formulation

Planta Medica ◽  
2011 ◽  
Vol 77 (05) ◽  
Author(s):  
W Ahmad ◽  
MS Khan ◽  
SMA Zaidi ◽  
SS Jameel ◽  
S Ahmad
Keyword(s):  
Quality Control ◽  
Control Analysis ◽  
Quality Control Analysis

UV spectroscopic method for determination of phenytoin in bulk and injection forms

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Quality Control ◽  
Spectrophotometric Method ◽  
Spectroscopic Method ◽  
Ich Guidelines ◽  
Precision And Accuracy ◽  
Routine Quality Control

Recent study was conducted to develop a simple UV spectrophotometric method to determine Phenytoin in bulk and injection form according to official requirement and validate as per ICH guidelines. λmax of Phenytoin was found 202 nm. Linearity existed perceived in the concentration assortment 2-8 μg/ml (r2 = 0.999) for the method. The method was validated pertaining to linearity, precision and accuracy studies, LOD and LOQ consistent with ICH guidelines. The existent method was establish to be simple, linear, precise, accurate as well as sensitive and can be applied for routine quality control enquiry for the analysis of Phenytoin in bulk and injection form.

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