scholarly journals Protection Against Ionizing Radiation-Induced Normal Tissue Damage by Resveratrol: A Systematic Review

2020 ◽  
Vol 52 (3) ◽  
pp. 298-303
Author(s):  
Alaba Tolulope Agbele ◽  
◽  
Olatunji Jimoh Fasoro ◽  
Olufemi Moses Fabamise ◽  
Oluwabusayo Odunola Oluyide ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ionizing Radiation ◽  
Tissue Damage ◽  
Normal Tissue ◽  
Normal Tissue Damage ◽  
Radiation Induced

Lovastatin attenuates ionizing radiation-induced normal tissue damage in vivo

2009 ◽  
Vol 92 (3) ◽  
pp. 492-499 ◽  
Author(s):  
Christian Ostrau ◽  
Johannes Hülsenbeck ◽  
Melanie Herzog ◽  
Arno Schad ◽  
Michael Torzewski ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Tissue Damage ◽  
Normal Tissue ◽  
Normal Tissue Damage ◽  
Radiation Induced

scholarly journals Radiation-Induced Normal Tissue Damage: Oxidative Stress and Epigenetic Mechanisms

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Jinlong Wei ◽  
Bin Wang ◽  
Huanhuan Wang ◽  
Lingbin Meng ◽  
Qin Zhao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Tissue Damage ◽  
Normal Tissue ◽  
Noncoding Rna ◽  
Nicotinamide Adenine Dinucleotide Phosphate ◽  
Redox System ◽  
Epigenetic Mechanisms ◽  
Rna Regulation ◽  
Normal Tissue Damage ◽  
Radiation Induced

Radiotherapy (RT) is currently one of the leading treatments for various cancers; however, it may cause damage to healthy tissue, with both short-term and long-term side effects. Severe radiation-induced normal tissue damage (RINTD) frequently has a significant influence on the progress of RT and the survival and prognosis of patients. The redox system has been shown to play an important role in the early and late effects of RINTD. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are the main sources of RINTD. The free radicals produced by irradiation can upregulate several enzymes including nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase), lipoxygenases (LOXs), nitric oxide synthase (NOS), and cyclooxygenases (COXs). These enzymes are expressed in distinct ways in various cells, tissues, and organs and participate in the RINTD process through different regulatory mechanisms. In recent years, several studies have demonstrated that epigenetic modulators play an important role in the RINTD process. Epigenetic modifications primarily contain noncoding RNA regulation, histone modifications, and DNA methylation. In this article, we will review the role of oxidative stress and epigenetic mechanisms in radiation damage, and explore possible prophylactic and therapeutic strategies for RINTD.

scholarly journals Regional Responses in Radiation-Induced Normal Tissue Damage

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 367
Author(s):  
Daniëlle C. Voshart ◽  
Julia Wiedemann ◽  
Peter van Luijk ◽  
Lara Barazzuol
Keyword(s):  
Side Effects ◽  
Radiation Dose ◽  
Tissue Damage ◽  
Normal Tissue ◽  
The Body ◽  
Target Cells ◽  
Neurocognitive Dysfunction ◽  
Normal Tissue Damage ◽  
Regional Responses ◽  
Radiation Induced

Normal tissue side effects remain a major concern in radiotherapy. The improved precision of radiation dose delivery of recent technological developments in radiotherapy has the potential to reduce the radiation dose to organ regions that contribute the most to the development of side effects. This review discusses the contribution of regional variation in radiation responses in several organs. In the brain, various regions were found to contribute to radiation-induced neurocognitive dysfunction. In the parotid gland, the region containing the major ducts was found to be critical in hyposalivation. The heart and lung were each found to exhibit regional responses while also mutually affecting each other’s response to radiation. Sub-structures critical for the development of side effects were identified in the pancreas and bladder. The presence of these regional responses is based on a non-uniform distribution of target cells or sub-structures critical for organ function. These characteristics are common to most organs in the body and we therefore hypothesize that regional responses in radiation-induced normal tissue damage may be a shared occurrence. Further investigations will offer new opportunities to reduce normal tissue side effects of radiotherapy using modern and high-precision technologies.

A Semiquantitative Probe for Radiation-Induced Normal Tissue Damage at the Molecular Level

1986 ◽  
Vol 105 (1) ◽  
pp. 76 ◽  
Author(s):  
G. Miller ◽  
D. Siemann ◽  
P. Scott ◽  
D. Dawson ◽  
K. Muldrew ◽  
...  
Keyword(s):  
Tissue Damage ◽  
Normal Tissue ◽  
Molecular Level ◽  
Normal Tissue Damage ◽  
Radiation Induced

18 Prevention of radiation induced normal tissue damage by cytokines and hyperbaric oxygen

1996 ◽  
Vol 36 (1) ◽  
pp. 167
Author(s):  
Xin Wang ◽  
Ivan Ding ◽  
Huchen Xie ◽  
Timothy Wu ◽  
Nancy Wersto ◽  
...  
Keyword(s):  
Hyperbaric Oxygen ◽  
Tissue Damage ◽  
Normal Tissue ◽  
Normal Tissue Damage ◽  
Radiation Induced
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