Natural history of prenatal isolated muscular ventricular septal defects

The natural history of the pulmonary arterial pressure in 23 children with isolated ventricular septal defects has been evaluated by serial night heart catheterization. In none of the 23 patients was there a significant increase in pulmonary arterial pressure. Eight patients showed a significant decrease. The direction of shunts did not change between procedures, and the clinical status was stable. Our experience correlated well with the majority of institutions. It would appear that the natural course of pulmonary arterial pressure in ventricular septal defect is not commonly one of progressive rise.

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Elucidation of the natural history of ventricular septal defects by serial Doppler color flow mapping studies

Journal of the American College of Cardiology ◽

10.1016/0735-1097(89)90270-2 ◽

1989 ◽

Vol 13 (5) ◽

pp. 1111-1118 ◽

Cited By ~ 52

Author(s):

Lisa K. Hornberger ◽

David J. Sahn ◽

Kimberly A. Krabill ◽

Frederick S. Sherman ◽

Richard E. Swensson ◽

...

Keyword(s):

Natural History ◽

Ventricular Septal Defects ◽

Flow Mapping ◽

Color Flow ◽

Septal Defects ◽

Color Flow Mapping ◽

History Of ◽

Doppler Color

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The natural history of ventricular septal defects in infancy

The American Journal of Cardiology ◽

10.1016/0002-9149(65)90047-0 ◽

1965 ◽

Vol 16 (5) ◽

pp. 634-653 ◽

Cited By ~ 228

Author(s):

Julien I.E. Hoffman ◽

Abraham M. Rudolph

Keyword(s):

Natural History ◽

Ventricular Septal Defects ◽

Septal Defects ◽

History Of

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Spontaneous closure of muscular ventricular septal defect identified by echocardiography in neonates

Cardiology in the Young ◽

10.1017/s1047951100007174 ◽

1998 ◽

Vol 8 (4) ◽

pp. 500-505 ◽

Cited By ~ 31

Author(s):

Zhong-Dong Du ◽

Nathan Roguin ◽

Xing-Jian Wu

Keyword(s):

Natural History ◽

Ventricular Septal Defect ◽

Septal Defect ◽

Spontaneous Closure ◽

Ventricular Septal Defects ◽

Muscular Ventricular Septal Defect ◽

Septal Defects ◽

Multiple Defects ◽

Single Defect ◽

History Of

AbstractMuscular ventricular septal defects were diagnosed by echocardiography in 97 neonates within 7 days of birth. In 82 of the neonates (84.5%), the defect was solitary, while 15 had multiple defects. The solitary defects was located at mid-septal, apical, anterior and inlet locations in 42 (51.2%), 21 (25.6%), 14 (17.1%) and 5 (6.1%) neonates, respectively. Multiple defects occurred in the apical, anterior and mid-septal areas. The diameter of the solitary defects ranged from 1 to 6 mm (2.3 ± 0.8 mm), while the multiple lesions were 1 to 4 mm in diameter (2.1 2.3 ± 0.8 mm 0.8 mm) in 28 instances in which they could measured. It proved possible to follow 79 of the patients for period of 10 to 13 months. The defects closed spontaneously in 56 (84.8%) of 66 patients with a single defect, and in 7 (53.8%) of 13 of those with multiple defects (P<0.05). For the solitary defects, the position and size were factors determining the likelihood and speed of closure. Defects located at the apical septum, or defects larger than 4 mm in diameter, closed slowly and at a later stage. Echocardiography is an useful technique in establishing of natural history of muscular ventricular septal defects encountered in neonates.

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The natural history of ventricular septal defects in infancy and childhood

The American Journal of Medicine ◽

10.1016/0002-9343(61)90046-8 ◽

1961 ◽

Vol 30 (3) ◽

pp. 357-371 ◽

Cited By ~ 49

Author(s):

Joshua Lynfield ◽

Benjamin M. Gasul ◽

Rene Arcilla ◽

Lawrence L. Luan

Keyword(s):

Natural History ◽

Ventricular Septal Defects ◽

Septal Defects ◽

Infancy And Childhood ◽

History Of

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Spontaneous Closure of Small Ventricular Septal Defects: Ten-Year Follow-up

PEDIATRICS ◽

10.1542/peds.63.2.204 ◽

1979 ◽

Vol 63 (2) ◽

pp. 204-206

Author(s):

Bruce S. Alpert ◽

David H. Cook ◽

P. Jacob Varghese ◽

Richard D. Rowe

Keyword(s):

Natural History ◽

Ventricular Septal Defect ◽

Septal Defect ◽

Spontaneous Closure ◽

Life Table Analysis ◽

Ventricular Septal Defects ◽

Septal Defects ◽

Table Analysis ◽

History Of

The natural history of small ventricular septal defect (VSD) was studied in 50 infants for up to 10.5 years. The VSD closed spontaneously in 34 patients. Life-table analysis of the data showed that by 10 years of age, 75% of small VSD will close spontaneously; the figure is higher for defects in the muscular septum (83%).

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