scholarly journals Predictive role of neutrophil-to-lymphocyte ratio on upstaging of organ-confined invasive urothelial bladder cancer to non-organconfined disease

2018 ◽  
Vol 44 (2) ◽  
pp. 119-124 ◽  
Author(s):  
Ertugrul Sefik ◽  
Bulent Gunlusoy ◽  
Ozgu Aydogdu ◽  
Yusuf Kadir Topcu ◽  
Yasin Ceylan ◽  
...  
2017 ◽  
Vol 103 ◽  
pp. 54-56 ◽  
Author(s):  
Kursat Atalay ◽  
Havva Kaldirim Erdogan ◽  
Ahmet Kirgiz ◽  
Senay Asik Nacaroglu

Author(s):  
Fabio Calabrò ◽  
Cora N. Sternberg

Although bladder cancer is considered a chemosensitive malignancy, the prognosis of patients with metastatic disease is poor, with a median survival of approximately 12–14 months in good prognosis patients and with cure in only a minority. The addition of new drugs to the standard cisplatin-based regimens has not improved these outcomes. In this chapter, we highlight the role of chemotherapy and the impact of the new targeted agents in the treatment of metastatic bladder carcinoma. A better understanding of the underlying biology and the molecular patterns of urothelial bladder cancer has led to clinical investigation of several therapeutic targets. To date, these agents have yet to demonstrate an improvement in overall survival. Urothelial cancer is extremely sensitive to checkpoint inhibition with both anti PD-1 and anti PDL1 antibodies. The future seems brighter with the advent of these new therapies.


2018 ◽  
Vol 17 (12) ◽  
pp. e2661-e2662
Author(s):  
M.D. Vartolomei ◽  
M. Ferro ◽  
F. Cantiello ◽  
G. Lucarelli ◽  
S. Di Stasi ◽  
...  

Tumor Biology ◽  
2015 ◽  
Vol 37 (5) ◽  
pp. 6197-6203 ◽  
Author(s):  
Mohamed Kacem Ben Fradj ◽  
Amani Kallel ◽  
Mohamed Mourad Gargouri ◽  
Mohamed Ali Ben Chehida ◽  
Ahmed Sallemi ◽  
...  

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