scholarly journals Longitudinal Evaluation of Gray Matter Atrophy in Mild Cognitive Impairment: A Voxel-Based Morphometric Study

2019 ◽  
Vol 37 (3) ◽  
pp. 53-57
Author(s):  
Berrin Cavusoglu ◽  
◽  
Emel Ada ◽  
Derya Durusu Emek Savas ◽  
Gorsev Gulmen Yener ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Gray Matter ◽  
Morphometric Study ◽  
Longitudinal Evaluation ◽  
Gray Matter Atrophy

Gray matter atrophy patterns of mild cognitive impairment subtypes

2012 ◽  
Vol 315 (1-2) ◽  
pp. 26-32 ◽  
Author(s):  
Haobo Zhang ◽  
Perminder S. Sachdev ◽  
Wei Wen ◽  
Nicole A. Kochan ◽  
John D. Crawford ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Gray Matter ◽  
Gray Matter Atrophy

scholarly journals Structural Brain Imaging Phenotypes of Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD) Found by Hierarchical Clustering

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Mikko Kärkkäinen ◽  
Mithilesh Prakash ◽  
Marzieh Zare ◽  
Jussi Tohka ◽  
for the Alzheimer's Disease Neuroimaging Initiative
Keyword(s):  
Alzheimer’S Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Hierarchical Clustering ◽  
Gray Matter ◽  
Brain Atrophy ◽  
Matter Density ◽  
Gray Matter Density ◽  
Gray Matter Atrophy ◽  
Density Maps

A hierarchical clustering algorithm was applied to magnetic resonance images (MRI) of a cohort of 751 subjects having a mild cognitive impairment (MCI), 282 subjects having received Alzheimer’s disease (AD) diagnosis, and 428 normal controls (NC). MRIs were preprocessed to gray matter density maps and registered to a stereotactic space. By first rendering the gray matter density maps comparable by regressing out age, gender, and years of education, and then performing the hierarchical clustering, we found clusters displaying structural features of typical AD, cortically-driven atypical AD, limbic-predominant AD, and early-onset AD (EOAD). Among these clusters, EOAD subjects displayed marked cortical gray matter atrophy and atrophy of the precuneus. Furthermore, EOAD subjects had the highest progression rates as measured with ADAS slopes during the longitudinal follow-up of 36 months. Striking heterogeneities in brain atrophy patterns were observed with MCI subjects. We found clusters of stable MCI, clusters of diffuse brain atrophy with fast progression, and MCI subjects displaying similar atrophy patterns as the typical or atypical AD subjects. Bidirectional differences in structural phenotypes were found with MCI subjects involving the anterior cerebellum and the frontal cortex. The diversity of the MCI subjects suggests that the structural phenotypes of MCI subjects would deserve a more detailed investigation with a significantly larger cohort. Our results demonstrate that the hierarchical agglomerative clustering method is an efficient tool in dividing a cohort of subjects with gray matter atrophy into coherent clusters manifesting different structural phenotypes.

Odor identification deficit in mild cognitive impairment and Alzheimer's disease is associated with hippocampal and deep gray matter atrophy

2016 ◽  
Vol 255 ◽  
pp. 87-93 ◽  
Author(s):  
Jesper Hagemeier ◽  
Matthew R. Woodward ◽  
Usama A. Rafique ◽  
Chaitanya V. Amrutkar ◽  
Niels Bergsland ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Gray Matter ◽  
Odor Identification ◽  
Gray Matter Atrophy ◽  
Deep Gray Matter

P2-157: Effects of APOE-ε4 on regional cerebral amyloid deposition and gray matter atrophy in mild cognitive impairment with PiB-PET-confirmed amyloid pathology: Results from J-ADNI

2013 ◽  
Vol 9 ◽  
pp. P405-P405
Author(s):  
Kazunari Ishii ◽  
Ryuichi Takahashi ◽  
Hiroshi Matsuda ◽  
Michio Senda ◽  
Kengo Ito ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Gray Matter ◽  
Amyloid Deposition ◽  
Amyloid Pathology ◽  
Apoe Ε4 ◽  
Gray Matter Atrophy ◽  
Cerebral Amyloid

Cued Recall Measure Predicts the Progression of Gray Matter Atrophy in Patients with Amnesic Mild Cognitive Impairment

2013 ◽  
Vol 36 (3-4) ◽  
pp. 197-210 ◽  
Author(s):  
Lejla Koric ◽  
Jean-Philippe Ranjeva ◽  
Olivier Felician ◽  
Maxime Guye ◽  
Francesca de Anna ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Gray Matter ◽  
Cued Recall ◽  
Gray Matter Atrophy ◽  
Amnesic Mild Cognitive Impairment

scholarly journals P3-217: MRI markers of mild cognitive impairment: A comparison between microstructural diffusion changes and macrostructural gray matter atrophy

2012 ◽  
Vol 8 (4S_Part_14) ◽  
pp. P536-P536
Author(s):  
Yu Zhang ◽  
Norbert Schuff ◽  
Monica Camacho ◽  
Linda Chao ◽  
Tom Fletcher ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Gray Matter ◽  
Gray Matter Atrophy

Cognitive Dysfunction and Gait Abnormalities in CKD

2021 ◽  
pp. CJN.16091020
Author(s):  
Melanie J. Koren ◽  
Helena M. Blumen ◽  
Emmeline I. Ayers ◽  
Joe Verghese ◽  
Matthew K. Abramowitz
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Confidence Interval ◽  
Cognitive Dysfunction ◽  
Gray Matter ◽  
Community Dwelling ◽  
Gray Matter Atrophy ◽  
Gait Abnormalities

Background and objectivesCognitive impairment is a major cause of morbidity in CKD. We hypothesized that gait abnormalities share a common pathogenesis with cognitive dysfunction in CKD, and therefore would be associated with impaired cognitive function in older adults with CKD, and focused on a recently defined gait phenotype linked with CKD.Design, setting, participants, & measurementsGait assessments and neuropsychological testing were performed in 312 nondisabled, community-dwelling older adults (aged ≥65 years). A subset (n=115) underwent magnetic resonance imaging. The primary cognitive outcome was the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) total scale score. Associations with cognitive function were tested using multivariable linear regression and nearest-neighbor matching. The risk of developing mild cognitive impairment syndrome was assessed using Cox proportional hazards models.ResultsLower eGFR was associated with lower RBANS score only among participants with the gait phenotype (P for interaction =0.04). Compared with participants with neither CKD nor the gait phenotype, adjusted RBANS scores were 5.4 points (95% confidence interval, 1.8 to 9.1) lower among participants with both, who demonstrated poorer immediate memory, visuospatial ability, delayed memory, and executive function. In a matched analysis limited to participants with CKD, the gait phenotype was similarly associated with lower RBANS scores (−6.9; 95% confidence interval, −12.2 to −1.5). Neuroimaging identified a pattern of gray matter atrophy common to both CKD and the gait phenotype involving brain regions linked with cognition. The gait phenotype was associated with higher risk of mild cognitive impairment (hazard ratio, 3.91; 95% confidence interval, 1.46 to 10.44) independent of eGFR.ConclusionsThe gait phenotype was associated with poorer function in a number of cognitive domains among older adults with CKD, and was associated with incident mild cognitive impairment independent of eGFR. CKD and the gait phenotype were associated with a shared pattern of gray matter atrophy.

scholarly journals Gray matter atrophy in patients with mild cognitive impairment/Alzheimer's disease over the course of developing delusions

2015 ◽  
Vol 31 (1) ◽  
pp. 76-82 ◽  
Author(s):  
Corinne E. Fischer ◽  
Windsor Kwan-Chun Ting ◽  
Colleen P. Millikin ◽  
Zahinoor Ismail ◽  
Tom A. Schweizer ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Gray Matter ◽  
Gray Matter Atrophy

scholarly journals Accelerometer Physical Activity is Associated with Greater Gray Matter Volumes in Older Adults Without Dementia or Mild Cognitive Impairment

2018 ◽  
Vol 74 (7) ◽  
pp. 1142-1151 ◽  
Author(s):  
Shannon Halloway ◽  
Konstantinos Arfanakis ◽  
JoEllen Wilbur ◽  
Michael E Schoeny ◽  
Susan J Pressler
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Gray Matter ◽  
Cross Sectional ◽  
Gray Matter Atrophy ◽  
Age Related ◽  
Gray Matter Volumes

Abstract Objectives Physical activity (PA) is a modifiable health behavior that can protect against age-related gray matter atrophy and cognitive dysfunction. Current studies of PA and gray matter failed to utilize device measures of PA and do not focus on adults >80 years. Thus, the purpose of this secondary analysis was to examine cross-sectional associations between accelerometer lifestyle PA and (a) gray matter volumes and (b) cognitive function, controlling for demographics, and health status. Method Participants were 262 older adults without dementia or mild cognitive impairment from Rush Memory and Aging Project, an epidemiological cohort study. Participants wore an accelerometer to assess total daily lifestyle PA, and completed anatomical magnetic resonance imaging to assess gray matter volumes and a neurocognitive test battery to assess cognitive function. Results Multivariate linear regression indicated that higher levels of total daily lifestyle PA was significantly related to larger gray matter volumes, F(2, 215) = 3.61, p = .027, including subcortical gray matter (β = 0.17, p = .007) and total gray matter (β = 0.11, p = .049), with no significant associations between lifestyle PA and cognitive function. Discussion These findings may inform future lifestyle PA interventions in order to attenuate age-related gray matter atrophy.

scholarly journals Executive dysfunction and gray matter atrophy in amnestic mild cognitive impairment

2014 ◽  
Vol 35 (3) ◽  
pp. 548-555 ◽  
Author(s):  
Dongming Zheng ◽  
Hongzan Sun ◽  
Xiaoyu Dong ◽  
Baiwei Liu ◽  
Yongchuan Xu ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Gray Matter ◽  
Executive Dysfunction ◽  
Amnestic Mild Cognitive Impairment ◽  
Gray Matter Atrophy
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