scholarly journals A healthcare organizational model of secondary prevention of cervical cancer among women of reproductive age

2020 ◽  
pp. 107-112
Author(s):  
T. M. Harelik ◽  
I. A. Naumov
Keyword(s):  
Cervical Cancer ◽  
Secondary Prevention ◽  
Medical Care ◽  
Cervical Intraepithelial Neoplasia ◽  
Intraepithelial Neoplasia ◽  
Reproductive Age ◽  
Organizational Model ◽  
Women Of Reproductive Age ◽  
Quality Of Medical Care

Objective: to develop a healthcare organizational model of secondary prevention of cervical cancer. Material and methods. The work analyzes the quality of medical care given to women of reproductive age living in Grodno region in whom cases of cervical intraepithelial neoplasia and cervical cancer were detected from 2010 to 2019. On the basis of the results of questioning of 200 women who had been treated in Oncology Ward No.3 of Grodno University Clinic, the most significant risk factors of the development of the pathology were identified. Statistical processing was performed by means of the program «Statistica» 10.0.Results. An effective model of secondary prevention of cervical cancer has been developed: from 2015 to 2019 compared to the previous quinquennium the detectability of cervical intraepithelial neoplasia and non-invasive cervical cancer increased by more than 17 % and 25 %, and the average parameters of the newly diagnosed morbidity were 69.97 ± 2.42 and 19.91 ± 2.28 per 100,000 women of reproductive age (p < 0.05). This made it possible to take timely measures for carcinogenesis interruption.Conclusion. The implementation of the healthcare organizational model of secondary prevention of cervical cancer contributes to improvement of the quality of medical care, and, therefore, maintainance of perspective realization of the child-bearing function for women of reproductive age.

scholarly journals DETEKSI DINI KANKER SERVIKS DENGAN PEMERIKSAAN SERVIKS DI KELURAHAN BULURAN KENALI KOTA JAMBI TAHUN 2017

2019 ◽  
Vol 1 (1) ◽  
pp. 56
Author(s):  
Julaecha Julaecha ◽  
Nurfitriani Nurfitriani
Keyword(s):  
Cervical Cancer ◽  
Early Detection Of Cancer ◽  
Malignant Disease ◽  
Intraepithelial Neoplasia ◽  
Cervical Cancer Prevention ◽  
Reproductive Age ◽  
Pap Smears ◽  
Women Of Reproductive Age ◽  
Before And After ◽  
Implementation Method

Cervical cancer is a malignant disease that occurs in the cervik. Course of the disease is preceded by the condition of pre-concerous lesions of the cerviks is the existence of dysplasi/cervical intraepithelial neoplasia (NIS). On each day is expeced to 40-45 new cases and about 20-25 people  die from cervical cancer. Based on those considered very necessary to provide education  on cervical cancer in women of reproductive age in the prevention of cervical cancer prevention effort.Target outcomes expected are: there is an increased knowledge an increase in knowledge between before and after extension and capable of early detection of cancer  serviks increase. Implementation method to provide counseling.The results  showed that there was important of mother’s interest in doing pap smears examination before and after counseling.

scholarly journals Natural History of Cervical Intraepithelial Neoplasia-2 in HIV-Positive Women of Reproductive Age

2018 ◽  
Vol 79 (5) ◽  
pp. 573-579
Author(s):  
Christine Colie ◽  
Katherine G. Michel ◽  
Leslie S. Massad ◽  
Cuiwei Wang ◽  
Gypsyamber DʼSouza ◽  
...  
Keyword(s):  
Natural History ◽  
Cervical Intraepithelial Neoplasia ◽  
Intraepithelial Neoplasia ◽  
Reproductive Age ◽  
Hiv Positive ◽  
Women Of Reproductive Age ◽  
Hiv Positive Women ◽  
History Of

scholarly journals Efficacy of immunological antivirus therapy for papillomavirus-associated grade I cervical intraepithelial neoplasia

2021 ◽  
Vol 8 (3) ◽  
pp. 155-166
Author(s):  
Ol’ga P. Vinogradova ◽  
Natal’ya A. Andreeva ◽  
Ol’ga V. Epifanova ◽  
Ol’ga I. Artemova
Keyword(s):  
Cervical Intraepithelial Neoplasia ◽  
Caspase 3 ◽  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Cervical Neoplasia ◽  
Reproductive Age ◽  
Interleukin 18 ◽  
Caspase 9 ◽  
Women Of Reproductive Age ◽  
Subsequent Activation

AIM: The study aimed to assess the effectiveness of alloferon in human papillomavirus (HPV)-associated cervical neoplasia (grade I) based on the analysis of the cytokine profile in cervical mucus as well as markers of apoptosis in cervical epithelial cells. MATERIALS AND METHODS: The study enrolled 98 women, including 55 women of reproductive age with cervical intraepithelial neoplasia (CIN) associated with HPV infection and 43 conditionally healthy women without HPV infection. Factors of cytokine response and markers of apoptosis under normal and pathology conditions were assessed and compared. RESULTS: The imbalance of pro-inflammatory and anti-inflammatory cytokines, in favor of the latter, is an important factor that supports the persistence of HPV-associated grade I CIN. Reducing caspase-3 and caspase-9, increasing interleukin-18, and subsequent activation of interferon gamma against the background of alloferon use are favorable signs of substantial elimination of the HPV. CONCLUSIONS: The results of this study show considerable elimination of HPV in patients with grade I CIN when using immunological antivirus therapy.

Significance of Persistent Inflammatory Cervical Smears in Sexually Active Women of Reproductive Age Group—A Prospective Study

2010 ◽  
Vol 2 (1) ◽  
pp. 45-48
Author(s):  
Nidhi Gupta
Keyword(s):  
Cervical Intraepithelial Neoplasia ◽  
Histopathological Examination ◽  
Intraepithelial Neoplasia ◽  
Reproductive Age ◽  
Sexually Active ◽  
Women Of Reproductive Age ◽  
Medical College ◽  
Cervical Smears ◽  
Cervical Biopsy ◽  
Inflammatory Changes

ABSTRACT To study the significance of persistent inflammatory cervical Papanicolaou smears, in sexually active women of reproductive age group attending the out patient department of department of obstetrics and gynecology, Sarojini Naidu Medical College and Hospitals, Agra were recruited. Patients with persistent inflammatory cervical smears were subjected to Schiller directed cervical biopsy for histopathological examination. Persistent inflammatory changes were seen in 37.6% cervical smears. Underlying cervical intraepithelial neoplasia (CIN) on histopathologic examination was found in 13.6% persisters. Prevalence of CIN was higher in women over 30 years and significantly so in women with parity higher than 2. It was further observed that severity of underlying CIN lesions increased with increasing duration of marital life. Objective To study the significance of persistent inflammatory cervical smears in sexually active women of reproductive age. Study design A prospective tertiary teaching hospital based study on 3000 sexually active women aged between 18 to 45 years attending the OPD from October 2006 to December 2008. Material and methods Sexually active women aged between 18 to 45 years with inflammatory smears attending the OPD of the department of obstetrics and gynecology, SN Medical College and Hospital were recruited for the study. Repeat cervical smears were taken after 3 months of systemic antimicrobials plus local antiseptics. Patients with persistent inflammatory cervical smears were subjected to Schiller directed cervical biopsy for histopathological examination. Relationship of age, parity, duration of marital life, different contraceptive practices and other high-risk factors were studied vis-ì-vis histopathological findings of cervical intraepithelial neoplasia. Results Persistent inflammatory changes were noted in 37.6% cervical smears. Underlying cervical intraepithelial neoplasia (CIN) on histopathalogic examination was seen in 13.6% persisters. Prevalence of CIN was higher in women over 30 years, and over para 3 uninfluenced by the presence of cervical lesion. Severity of underlying CIN lesions increased with increasing duration of marital life. Conclusion Women with persistent inflammatory cervical smears, especially if she is above 30 years, sexually active for 10 years and is third para, should have further evaluation with cervical biopsy.

The role of immunohistochemistry in the diagnosis of cervical intraepithelial neoplasia of different severity

2016 ◽  
pp. 138-140
Author(s):  
S.I. Zhuk ◽  
◽  
O.A. Taran ◽  
A.N. Koshmienskaya ◽  
T.V. Lobastova ◽  
...  
Keyword(s):  
Protein Expression ◽  
Cervical Intraepithelial Neoplasia ◽  
Precancerous Lesions ◽  
Molecular Genetic ◽  
Intraepithelial Neoplasia ◽  
Reproductive Age ◽  
Moderate Degree ◽  
Ki 67 ◽  
The Third ◽  
Diagnosis And Prognosis

The objective: the finding of protein expression of apoptosis regulator BCL-2, Smooth Muscule Actin and the antigen Ki-67 in cervical intraepithelial neoplasia of different severity to optimize the diagnosis and prognosis of the disease. Patients and methods. The study involved 42 women of reproductive age with cervical intraepithelial the neoplasia of the cervix varying degrees applied to the doctor of cervical pathology Zhitomir regional oncologic dispensary. All women (n=42) were divided into groups. The first group included 15 patients (35.7%) with cervical intraepithelial neoplasia with mild. The second group included 13 women (31%) with cervical intraepithelial neoplasia a moderate degree. The third group was represented by patients with cervical intraepithelial neoplasia with severe – 14 respondents (33.3 per cent). Results. Marker BCL-2 in patients of the first group was positive in 7 patients (46.7%), Smooth Muscule Actin was positive in 9 patients (60%) and Ki-67 was diagnosed in 8 of the surveyed women (53.3%). In the second group of BCL-2 was positive in 8 patients (61.5%), Clone 124, Smooth Muscule Actin, Clone 1A4 was positive in 9 patients (69.2%), and Ki-67 was diagnosed in 12 of the surveyed women (92.3%). Marker BCL-2 in patients of the third group was positive in 12 patients (85.7%), Smooth Muscule Actin was positive in 10 patients (71.4%) and Ki-67 was diagnosed in 13 of the surveyed women (92.9% ). Conclusion. Carcinogenesis is associated with molecular genetic damage to the cervix. Some of the products of this process can be used as prognostic and diagnostic markers of tumor progression. Determination of protein expression of apoptosis regulator BCL-2, Smooth Muscule Actin and the antigen Ki-67 in cervical intraepithelial neoplasia makes it possible to accurately verify the diagnosis and to predict the course of pathological changes in the flat epithelium of the cervix. Key words: cervical intraepithelial neoplasia, cervical cancer, morphological diagnostics of precancerous lesions, BCL-2, Smooth Muscule Actin, Ki-67.

Responsibility for a quality of medical care provided via telemedicine

2018 ◽  
Vol 2018 (1-2) ◽  
pp. 9-15
Author(s):  
Morozov S.P. ◽  
◽  
Vladzymyrskyy A.V. ◽  
Varyushin M.S. ◽  
Aronov A.V. ◽  
...  
Keyword(s):  
Medical Care ◽  
Quality Of Medical Care
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