Tp53 Expression And Ki-67 Proliferation Index In Surface Epithelial Tumors Of The Ovary And Their Relationship With The Histopathological Prognostic Parameters

Alteration of β-catenin expression is involved in the development and evolution of hepatocellular carcinoma (HCC); β-catenin is able to influence tumor cell proliferation. We analyzed the immunohistochemical (IHC) expression of β-catenin on a group of 32 patients diagnosed with HCC using the anti-β-catenin monoclonal antibody (clone E247). We correlated the expression of β-catenin with the proliferation index of Ki-67 (PI Ki-67), the mitotic index (MI) and other clinical and pathological features. We observed an altered β-catenin expression in 58.38% of all HCC cases. This expression was insignificantly correlated with tumor size (]5 cm) (p = 0.683), histological grade G1-G2 (p = 0.307), vascular invasion (p = 0.299) and advanced pT stage (p = 0.453); we obtained a significantly higher MI in HCC with altered β-catenin expression (p = 0.018), as compared to HCC without overexpression (1.66 � 1.37) (p = 0.038) and a PI Ki-67 of 22.49 � 20.1 and 28.24 � 18.2, respectively in tumors with altered β-catenin expression with insignificant differences compared to HCC without overexpression (25.95 � 15.2) (p = 0.682 and p = 0.731, respectively). According to the results we obtained, aberrant β-catenin expression in HCC was correlated with a high mitotic index, therefore playing an important role in tumor progression by stimulating tumor cell proliferation; non-nuclear β-catenin overexpression can have a pathological significance in HCC, especially in cases of HCC associated with hepatitis B virus (HBV) infection.

Download Full-text

Strategic Aspects of NPY-Based Monoclonal Antibodies for Diagnosis and Treatment of Breast Cancer

Current Protein and Peptide Science ◽

10.2174/1389203721666200918151604 ◽

2020 ◽

Vol 21 (11) ◽

pp. 1097-1102

Author(s):

Drashti Desai ◽

Pravin Shende

Keyword(s):

Breast Cancer ◽

Monoclonal Antibodies ◽

Diagnosis And Treatment ◽

Detection Methods ◽

Active Immunotherapy ◽

Immune Checkpoints ◽

Proliferation Index ◽

Protein Fusion ◽

Ki 67 ◽

Cost Efficient

: Immunotherapy emerges as a treatment strategy for breast cancer marker, diagnosis and treatment. In this review, monoclonal antibodies (mAbs)-based passive and peptide vaccines as active immunotherapy approaches like activation of B-cells and T-cells are studied. Passive immunotherapy is mAbs-based therapy effective against tumor cells, which acts by targeting HER2, IGF 1R, VEGF, BCSC and immune checkpoints. Neuropeptide Y (NPY) and GPCR are the areas of interest to target BC metastases for on-targeting therapeutic action. Neuropeptide S (NPS) or NPS receptor 1, acts as a biomarker for Neuroendocrine tumors (NET), mostly characterized by synaptophysin and chromogranin-A expression or Ki-67 proliferation index. The protein fusion technologies arise as a promising avenue in plant expression systems for increased recombinant Ab accumulation and cost-efficient purification. Recently, mAbs-based immunotherapy effectiveness is appreciated as a novel therapeutic combination of chemotherapy and immunotherapy to reduce the side effects and improve therapeutic responsiveness. Synthetic drug resistance will be overcome by mAbs-based therapy through several clinical trials and detection methods need to be optimized for accuracy and precision. Pharmacokinetic attributes need to be accessed for preferred receptor-agonist activity without ligand accumulation.

Download Full-text

Calcitonin-Negative Neuroendocrine Carcinoma of the Thyroid Gland: Case Report and Literature Review

Case Reports in Oncology ◽

10.1159/000510807 ◽

2021 ◽

pp. 112-122

Author(s):

Ricardo Fernández-Ferreira ◽

Ildefonso Roberto De la Peña-López ◽

Karla Walkiria Zamudio-Coronado ◽

Luis Antonio Delgado-Soler ◽

María Eugenia Torres-Pérez ◽

...

Keyword(s):

Thyroid Carcinoma ◽

English Language ◽

Neoadjuvant Treatment ◽

Complete Response ◽

Cervical Region ◽

Proliferation Index ◽

Ki 67 ◽

Definitive Evidence ◽

Criteria For Diagnosis ◽

Fdg Pet Ct

Calcitonin-negative neuroendocrine tumor (CNNET) of the thyroid is an extremely rare entity. In some of the previously reported cases within the literature, the terms “atypical medullary thyroid carcinoma,” “calcitonin-free oat cell carcinoma,” and “a distinct clinical entity” were applied to NETs without definitive evidence of calcitonin production. In the English-language literature, not only are there only few reported cases of CNNET, but the criteria for diagnosis in these cases are also controversial. Most of the current published cases were also treated surgically for local disease. We describe a case of NET of the thyroid with calcitonin, chromogranin A and thyroglobulin negativity, synaptophysin and TTF-1 positivity, and a high Ki-67 proliferation index with metastases in the cervical region as well as mediastinal adenopathies. This case was considered an unresectable thyroid carcinoma, and chemotherapy including cisplatin and etoposide was started as neoadjuvant treatment at the department of medical oncology. Total thyroidectomy plus bilateral and central cervical dissection was performed, and the patient underwent 2 cycles of adjuvant radiotherapy. Currently, the patient’s 18F-FDG-PET/CT findings show a complete response 17 months after diagnosis. In conclusion, CNNET of the thyroid is very rare and there is limited evidence regarding treatment in patients with metastases. Chemotherapy including cisplatin and etoposide as well as early aggressive surgical resection appears to positively impact patients’ survival.

Download Full-text

Prognostic Implications of p53 Nuclear Overexpression and High Proliferation Index of Ki-67 in Adult Soft-Tissue Sarcomas

JNCI Journal of the National Cancer Institute ◽

10.1093/jnci/86.7.549 ◽

1994 ◽

Vol 86 (7) ◽

pp. 549-554 ◽

Cited By ~ 109

Author(s):

Marija Drobnjak ◽

Esther Latres ◽

Daphna Pollack ◽

Martin Karpeh ◽

Maria Dudas ◽

...

Keyword(s):

Soft Tissue ◽

Soft Tissue Sarcomas ◽

Proliferation Index ◽

Ki 67 ◽

Prognostic Implications

Download Full-text

High Ki‐67 proliferation index and lack of chemotherapy are associated with reduced overall survival in patients with triple negative breast cancer: a retrospective cohort in a major breast center in Hong Kong

Surgical Practice ◽

10.1111/1744-1633.12527 ◽

2021 ◽

Author(s):

Hung Ka Wai Ray ◽

Chiu Hoi Wun Tiffany ◽

Tsoi Yee Kei Violet ◽

Chan Wing Cheong

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Hong Kong ◽

Triple Negative Breast Cancer ◽

Retrospective Cohort ◽

Triple Negative ◽

Proliferation Index ◽

Ki 67 ◽

Breast Center ◽

Major Breast

Download Full-text

Cellular Proliferation Index between Carcinoma Ex-Pleomorphic Adenoma and Pleomorphic Adenoma

Brazilian Dental Journal ◽

10.1590/0103-6440201300369 ◽

2015 ◽

Vol 26 (4) ◽

pp. 416-421 ◽

Cited By ~ 2

Author(s):

Fernanda Viviane Mariano ◽

Ana Flávia Costa ◽

Rogério Oliveira Gondak ◽

Antonio Santos Martins ◽

André Del Negro ◽

...

Keyword(s):

Minimally Invasive ◽

Pleomorphic Adenoma ◽

Cellular Proliferation ◽

Sarcomatoid Carcinoma ◽

Proliferation Index ◽

Carcinoma Ex Pleomorphic Adenoma ◽

Proliferative Index ◽

Salivary Duct ◽

Ki 67 ◽

Duct Carcinoma

<p>Carcinoma ex pleomorphic adenoma (CXPA) has been considered an interesting model of carcinogenesis, presenting various histological subtypes and invasiveness phase. The objective was to determine the proliferative index of CXPA and comparing to pleomorphic adenoma (PA). Thirty six cases of CXPA (36 PA) and 22 areas of PA in CXPA (residual PA) were studied by Ki-67 expression. All CXPA cases were classified according to invasiveness phase (intracapsular, minimally and frankly invasive) and histopathological subtypes. Data was statistically analyzed by Wilcoxon, Mann-Whitney and Kruskal-Wallis tests. CXPA included 5 intracapsular, 9 minimally invasive and 22 frankly invasive cases. Fifteen cases corresponded to salivary duct carcinoma, 7 to adenocarcinoma NOS, 7 myoepithelial, 5 epithelial-myoepithelial, one case of squamous cell and one case of sarcomatoid carcinoma. The Ki-67 index of PA and residual PA were significantly lower than CXPA. Intracapsular and minimally invasive showed smaller proliferative index than frankly invasive. Considering the subtypes of CXPA, there was not a statistic difference among them. Ki-67 is a useful marker in the differential diagnosis of PA and CXPA, even when in the early invasive phase.</p>

Download Full-text