Implementation of a Design Tool for Conceptual Design of Integrally Fastened Assemblies

1999 ◽  
Author(s):  
Paul G. Lee ◽  
Daeyong Lee ◽  
Gary A. Gabriele
Keyword(s):  
Design Methodology ◽  
Software Tool ◽  
Design Tool ◽  
Ease Of Use ◽  
Design Concepts ◽  
Java Programming ◽  
Mechanical Assemblies ◽  
Integral Attachment ◽  
Formal Design

Abstract The proper use of integral attachment features in mechanical assemblies has been more of an art than an engineering science. An organized set of design steps for generating conceptual integral attachment designs has recently been developed based on work begun by Bonenberger. These steps outline a formal design methodology for exploring the design space of possible alternative attachment concepts. This paper describes the development of a software tool that attempts to implement the integral attachment design methodology to assist a designer in developing attachment concepts. The tool is implemented using the Java programming language. A graphical interface is used to present the methodology as a series of options that approximate the design situation. This hides many of the details of the methodology in favor of ease of use. The end result is a set of suggestions for integral fasteners that are matched to the design situation. A discussion of how the hundreds of images are handled using Java is provided. A sample case study illustrates the approach of the program. The tool represents one of the few examples of a design tool aimed specifically at generating design concepts.

Unrestrictive protein modification localization and quality control for open search of mass spectra

2018 ◽  
Author(s):  
Zhiwu An ◽  
Fuzhou Gong ◽  
Yan Fu
Keyword(s):  
Mass Spectrometry ◽  
Quality Control ◽  
Tandem Mass Spectrometry ◽  
Mass Spectra ◽  
Protein Modification ◽  
Software Tool ◽  
Tandem Mass ◽  
Simulation Data ◽  
Post Translational Modifications

We have developed PTMiner, a first software tool for automated, confident filtering, localization and annotation of protein post-translational modifications identified by open (mass-tolerant) search of large tandem mass spectrometry datasets. The performance of the software was validated on carefully designed simulation data. <br>

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