scholarly journals Chronic Hepatitis C Prevalence, Genotype Distribution and Treatment Responses at Marmara University Pendik Training and Research Hospital Between 2014-2018

ANKEM Dergisi ◽  
2020 ◽  
Author(s):  
Buket ERTÜRK ŞENGEL ◽  
Tuğçe BAŞARI ◽  
Elif TÜKENMEZ TİGEN ◽  
Rabia CAN SARINOĞLU ◽  
Barış CAN ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Genotype Distribution ◽  
Research Hospital ◽  
Training And Research ◽  
Treatment Responses

Investigation of Hepatitis C Virus Genotype Distribution in Patients with Chronic Hepatitis C Infections in Antalya Training and Research Hospital, Turkey

2014 ◽  
Vol 48 (3) ◽  
pp. 484-490 ◽  
Author(s):  
Yeşim ÇEKİN ◽  
Nilgün GÜR ◽  
Ayhan Hilmi ÇEKİN ◽  
İmre ALTUĞLU ◽  
Rüçhan YAZAN SERTÖZ
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Genotype Distribution ◽  
Virus Genotype ◽  
Research Hospital ◽  
Training And Research

scholarly journals Chronic hepatitis C in Austria, 1992–2006: genotype distribution and demographic factors

2010 ◽  
Vol 15 (8) ◽  
Author(s):  
A Maieron ◽  
S Metz-Gercek ◽  
F Hackl ◽  
C Luger ◽  
A Ziachehabi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Hepatitis ◽  
Liver Disease ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Risk Groups ◽  
Hcv Rna ◽  
Age Difference ◽  
Genotype Distribution ◽  
Upper Austria

Chronic hepatitis C is a leading cause of end-stage liver disease and, with a worldwide prevalence of up to 3%, is a pandemic infectious disease. Austria, like most western European countries can be considered as a low prevalence country. This analysis aimed to assess the distribution of hepatitis C virus (HCV) genotypes in patients with chronic HCV infection in Upper Austria. Between September 1992 and December 2006, we identified 1,318 consecutive patients who tested positive for HCV RNA. Genotyping was routinely performed in 1,239 of the 1,318 patients, and in a subgroup of 617 patients data on the source of transmission were collected. Additionally we obtained data on liver histology and body mass index in a subsample of 273 of the 617 patients. Hepatitis C genotypes 1, 2, 3, 4, 6 and co-infections were found in 80.4%, 4.5%, 12.3%, 2.7%, 0.1% and 0.2% of the patients, respectively. There was a highly significant age difference in relation to gender at the time of diagnosis of chronic hepatitis C, with women being older than men (men: 45.0 years; women: 49.3 years; p<0.0001). The number of new cases of chronic hepatitis C decreased substantially over the last decade, but although risk factors for obtaining HCV are well established, we did not find a decrease in the age of first diagnosis. Besides consistent screening in defined risk groups it is important to raise awareness for risk factors for HCV acquisition and liver disease progression.

scholarly journals Early Prediction of Nonresponders to Treatment with Interferon Alpha-2B and Ribavirin in Patients with Chronic Hepatitis C

2003 ◽  
Vol 17 (8) ◽  
pp. 483-487 ◽  
Author(s):  
Louis WC Liu ◽  
George Tomlinson ◽  
Tony Mazzulli ◽  
Alison Murray ◽  
Jenny Heathcote
Keyword(s):  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Interferon Alpha ◽  
Baseline Viral Load ◽  
Hcv Rna ◽  
Interferon Alpha 2B ◽  
Quantitative Measurements ◽  
Treatment Responses

BACKGROUND: Treatment of chronic hepatitis C virus (HCV) infection with interferon alpha-2b and ribavirin is costly in terms of side effects, medical resources and drug costs. Furthermore, less than 50% of patients overall have a sustained virological response (SVR).OBJECTIVE: To determine if the log fall in HCV RNA between baseline and week 1 (b-wk1) and between baseline and week 4 (b-wk4) after starting treatment could identify the nonresponders.PATIENTS AND METHODS: Sixty-three patients who had completed a full course of therapy were identified. Quantitative measurements of HCV RNA were analyzed from stored sera, collected prospectively.RESULTS: SVR was achieved in 47.1% and 47.3% of patients in the b-wk1 and b-wk4 groups, respectively. No patients had an SVR with a fall in HCV RNA of less than 0.35 log10and 1.05 log10at week 1 and week 4, respectively. This accounted for 44.4% and 51.7% of the nonresponders in the b-wk1 and b-wk4 groups, respectively. Once the decline in viral load was known, genotype, age, sex and baseline viral load did not provide additional power in predicting treatment responses.CONCLUSION: A fall of 1.05 log10in HCV RNA at week 4 predicts those patients who will not respond, identifying one-half of all nonresponders; this allows therapy to be stopped early, without depriving any patient who would have an SVR from treatment.

Genotype distribution in relation to viral load in a large cohort of Indian patients with chronic hepatitis C virus infection: A retrospective analysis

2019 ◽  
Vol 38 (2) ◽  
pp. 110-116 ◽  
Author(s):  
Balkumar Reddy Panyala ◽  
Rathindra Mohan Mukherjee ◽  
Himaja Devarakonda ◽  
Sivasathish Tadivaka ◽  
Nagaraja Rao Padaki ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Viral Load ◽  
Hepatitis C ◽  
Virus Infection ◽  
Retrospective Analysis ◽  
Chronic Hepatitis C ◽  
Genotype Distribution ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus

scholarly journals Parallel expression profiling of hepatic and serum microRNA-122 associated with clinical features and treatment responses in chronic hepatitis C patients

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Azeem Mehmood Butt ◽  
Arsalan Jamil Raja ◽  
Shafiqa Siddique ◽  
Jahangir Sarwar Khan ◽  
Muhammad Shahid ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Clinical Features ◽  
Expression Profiling ◽  
Serum Microrna ◽  
Treatment Responses ◽  
Chronic Hepatitis C Patients

scholarly journals EGFR rs11506105 and IFNL3 SNPs but not rs8099917 are strongly associated with treatment responses in Iranian patients with chronic hepatitis C

2017 ◽  
Vol 18 (3) ◽  
pp. 144-151 ◽  
Author(s):  
M Asnavandi ◽  
M Zargar ◽  
F Vaziri ◽  
F R Jamnani ◽  
S Gharibzadeh ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Treatment Responses ◽  
Iranian Patients
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