scholarly journals Retrospective Evaluation of Toxoplasma gondii, Rubella and Cytomegalovirus Seropositivity and Avidity Test Results in Patients Admitted to İU-C Cerrahpaşa Medical Faculty Hospital Between 2013-2018

2020 ◽  
Author(s):  
Esra Demir ◽  
Harika Öykü Dinç ◽  
Doğukan Özbey ◽  
Seher Akkuş ◽  
Sevgi Ergin ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Medical Faculty ◽  
Test Results ◽  
Retrospective Evaluation ◽  
Cerrahpasa Medical Faculty ◽  
Avidity Test

EVALUATION OF Toxoplasma gondii SEROPREVALENCE AND IGG AVIDITY TEST RESULTS AMONG CHILDBEARING-AGE WOMEN IN KARABUK PROVINCE

2021 ◽  
Vol 6 (12) ◽  
pp. 98-103
Author(s):  
Meryem COLAK ◽  
Nergis ASGIN
Keyword(s):  
Toxoplasma Gondii ◽  
Congenital Toxoplasmosis ◽  
Epidemiological Data ◽  
Test Results ◽  
Childbearing Age ◽  
Igg Antibody ◽  
Seropositivity Rate ◽  
Igg Avidity ◽  
Avidity Test ◽  
Childbearing Age Women

Toxoplasmosis is a zoonotic infectious disease that is common worldwide and caused by the Toxoplasma gondii. Congenital toxoplasmosis is one of the major complications of this infection. The present study aimed to investigate T.gondii seroprevalence and evaluate the IgG avidity test results among childbearing- age women retrospectively. A total of 9401 samples obtained from childbearing -age (15-49 years of age) women who attended Karabuk University Training and Research Hospital between February 2016- January 2020, over the four-year, were included in the study.The Toxoplasma-IgM, Toxoplasma-IgG antibody, and Toxoplasma IgG avidity tests were analyzed chemiluminescent method by using ARCHITECT I 2000 SR immunoassay device (Abbott Laboratories, USA). Toxoplasma-IgM and Toxoplasma-IgG seropositivity were detected as 0.7% (67/9401) and 15.7% (1415/9005) respectively. A high percentage of Toxoplasma-IgM and Toxoplasma-IgG seropositivity were detected among 31-35 years of age group. The Toxoplasma seropositivity increased by age, but no statistically difference was found (P >0.05).The Toxoplasma IgG avidity was high in 45 patients (69.4%), low avidity was detected in 16 patients (22.6%) and from the remaining 6 patients were borderline (8%). The Toxoplasma IgM and IgG seropositivity rate decreased 2016 to 2020. The highest Toxoplasma IgM and IgG seropositivity were in 2016 with 1.2% and 16.8%, respectively. The T. gondi seropositivity rate was decreased from 2016 to 2020; it is probably a result of increasing awareness of the disease among patients. We think our results will contribute to the epidemiological data in our province and country and raise awareness.

scholarly journals The Frequency and Results of QuantiFERON-TB Gold Test in Parallel with the Place of the Clinical Usage in the Cerrahpaşa Medical Faculty Clinics: A 2-year Retrospective Evaluation

2020 ◽  
Vol 73 (3) ◽  
pp. 203-207
Author(s):  
Serhat Sirekbasan ◽  
Harika Öykü Dinç ◽  
Doğukan Özbey ◽  
Seher Akkus ◽  
Suat Sarıbaş ◽  
...  
Keyword(s):  
Medical Faculty ◽  
Retrospective Evaluation ◽  
Cerrahpasa Medical Faculty

Usefulness of Toxoplasma gondii recombinant antigens (GRA1, GRA7 and SAG1) in an immunoglobulin G avidity test for the serodiagnosis of toxoplasmosis

2006 ◽  
Vol 100 (2) ◽  
pp. 333-337 ◽  
Author(s):  
H. Pietkiewicz ◽  
E. Hiszczyńska-Sawicka ◽  
J. Kur ◽  
E. Petersen ◽  
H. V. Nielsen ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Immunoglobulin G ◽  
Recombinant Antigens ◽  
Avidity Test

School of Evidence-Based Medicine: The Cerrahpasa Medical Faculty Practice of Evidence-Based Medicine Training

2021 ◽  
Vol 45 (1) ◽  
pp. 33-42
Author(s):  
Ozlem Serpil Cakmakkaya ◽  
◽  
Kaan Can Demirbas ◽  
Muhittin Onur Yaman ◽  
Ozgur Kasapcopur ◽  
...  
Keyword(s):  
Evidence Based Medicine ◽  
Medical Faculty ◽  
Evidence Based ◽  
Cerrahpasa Medical Faculty ◽  
Based Medicine

scholarly journals Correlation between specific IgM levels and percentage IgG-class antibody avidity to Toxoplasma gondii

2008 ◽  
Vol 50 (4) ◽  
pp. 237-242 ◽  
Author(s):  
Marcel Leite ◽  
Sonia Siciliano ◽  
Lucia Silvieri A. Rocha ◽  
Teresa R. Justa ◽  
Katia Regina César ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Acute Phase ◽  
Turnaround Time ◽  
Antibody Avidity ◽  
Igg Avidity ◽  
Avidity Test ◽  
Evaluation Test ◽  
Fetal Malformations ◽  
Two Parameters ◽  
Class Antibody

Toxoplasmosis is an usually asymptomatic worldwide disseminated infection. In its congenital presentation it may lead to abortion or fetal malformations. Antenatal evaluation is considered of paramount importance to identify seronegative women and allow for prophylaxis. Recent improvements in sensitivity of IgM tests has made IgM detection an extremely protracted acute phase marker, and IgG avidity evaluation test became necessary. Observation has shown that a correlation can be established between IgM levels and avidity percentages, suggesting that frequently the avidity test may not be necessary. In this study we analyzed Toxoplasma gondii IgM levels of 202 samples and their IgG avidity percentages, in order to define specific levels whose IgM quantification could by itself define serodiagnosis and therefore make the avidity evaluation unnecessary. We showed that for IgM levels bellow 2.0 and above 6.0 serodiagnosis of toxoplasmosis could be established without need of IgG avidity test. IgM levels between these two parameters are associated with varying avidity indexes highlighting the importance of its evaluation as a means to confirm toxoplasmosis. Following this demonstration it was possible to avoid the avidity test for 75% of the cases, to reduce the turnaround time and to reduce costs.

Spatio-temporal variations and age effect on Toxoplasma gondii seroprevalence in seals from the Canadian Arctic

Parasitology ◽  
2011 ◽  
Vol 138 (11) ◽  
pp. 1362-1368 ◽  
Author(s):  
A. SIMON ◽  
M. CHAMBELLANT ◽  
B. J. WARD ◽  
M. SIMARD ◽  
J. F. PROULX ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Serological Test ◽  
Canadian Arctic ◽  
Temporal Variations ◽  
Test Results ◽  
Source Of Infection ◽  
Food Borne ◽  
Significant Public Health ◽  
Polymerase Chain ◽  
Spatio Temporal

SUMMARYToxoplasmosis is a significant public health threat for Inuit in the Canadian Arctic. This study aimed to investigate arctic seals as a possible food-borne source of infection. Blood samples collected from 828 seals in 7 Canadian Arctic communities from 1999 to 2006 were tested for Toxoplasma gondii antibodies using a direct agglutination test. Polymerase chain reaction (PCR) was used to detect T. gondii DNA in tissues of a subsample of seals. Associations between seal age, sex, species, diet, community and year of capture, and serological test results were investigated by logistic regression. Overall seroprevalence was 10·4% (86/828). All tissues tested were negative by PCR. In ringed seals, seroprevalence was significantly higher in juveniles than in adults (odds ratio=2·44). Overall, seroprevalence varied amongst communities (P=0·0119) and by capture year (P=0·0001). Our study supports the hypothesis that consumption of raw seal meat is a significant source of infection for Inuit. This work raises many questions about the mechanism of transfer of this terrestrial parasite to the marine environment, the preponderance of infection in younger animals and the natural course of infection in seals. Further studies to address these questions are essential to fully understand the health risks for Inuit communities.

scholarly journals Toxoplasmosis and pregnancy: Perinatal results and association of the IgG avidity test with congenital infection in pregnant women with positive anti-Toxoplasma gondii IgM [Abstract in English]

2010 ◽  
Vol 20 (1) ◽  
pp. 45
Author(s):  
Virgílio Gonçalves de Souza-Júnior ◽  
Ernesto Antonio Figueiró-Filho ◽  
Danilo De Cerqueira Borges ◽  
Vanessa Marcon Oliveira ◽  
Lílian Rezende Coelho
Keyword(s):  
Toxoplasma Gondii ◽  
Pregnant Women ◽  
Predictive Value ◽  
Congenital Infection ◽  
Neonatal Infection ◽  
High Avidity ◽  
Igg Avidity ◽  
Risk Pregnancy ◽  
Avidity Test ◽  
Acute Toxoplasmosis

AIMS: To verify the perinatal outcomes in pregnant women with acute toxoplasmosis, and to determine if there was association between the results of Toxoplasma gondii-specific IgG avidity test and the presence or absence of fetal/neonatal infection. METHODS: A cross-sectional study included pregnant women with serological diagnosis of acute toxoplasmosis (presenting a positive Toxoplasma gondii-specific IgM test) attended at the outpatient unit for high-risk pregnancy of the Faculty of Medicine, Federal University of Mato Grosso do Sul, Brazil, in the period from November 2002 to November 2007. Test results demonstrating IgG avidity index above 30% were considered high avidity, while values below 30% were considered low avidity. Fetal and/or neonatal infection was defined by positive result for the polymerase chain reaction in amniotic fluid, or by a positive Toxoplasma gondii-specific IgM test in the newborn's serum. RESULTS: Considering all pregnant women referred to the outpatient unit for high-risk pregnancy in the period of study, frequency of pregnant women with positive Toxoplasma gondii-specific IgM was 10.8% (176/1.634). The rate of congenital infection in these patients was 4% (7/176). The IgG avidity test was performed in 162 patients (92% of the 176 pregnant women with positive IgM), and the avidity was high in 144 (88.9%). There was an association (p=0.003) between high avidity and no fetal/neonatal toxoplasmosis in our sample, with a prevalence ratio of 13.4 (confidence interval [CI] 95% 2.2-86.6). The positive predictive value of the avidity test (probability of congenital infection with a low avidity) was 22% (95% 6%-47%), while the negative predictive value (probability of absence of congenital infection with a high avidity) was 98% (95% CI 94% -99%). CONCLUSIONS: In this study the rate of congenital infection in pregnant women diagnosed with acute toxoplasmosis was 4%. In pregnant women with positive Toxoplasma gondii-specific IgM, results of Toxoplasma gondii-specific IgG avidity test were associated with the presence or absence of congenital infection, with a high negative predictive value (no fetal/neonatal infection when avidity was high).

scholarly journals Evaluation of Toxoplasma gondii Seropositivity and the Results of IgG Avidity Test of Patients with Suspected Toxoplasmosis

2018 ◽  
Author(s):  
Salih Maçin ◽  
Duygu Fındık ◽  
Aslıhan Demircan ◽  
Uğur Arslan ◽  
Hatice Türk Dağı
Keyword(s):  
Toxoplasma Gondii ◽  
Igg Avidity ◽  
Avidity Test
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