COVID-19) PANDEMIC ON CHILDREN WITH SPEECH AND LANGUAGE DISORDERS AND THEIR FAMILIES

Objective: The aim is to determine the effects of the covid-19 pandemic on the functions and psychosocial conditions of children with speech and language disorders and their families. Material-Metod: Within the scope of the study, a questionnaire form created by the researchers through "Google Forms" was applied online to 70 families with speech and language disorders and 30 families with healthy children, feedback was obtained from the families of 100 children. In the questionnaire form applied to the families; before and during the covid-19 pandemic, there are questions about families' quality time with their children, daily life activities, emotional and anxiety situations. Study data were collected between June-July 2020. Results: Spending quality time with their families before the pandemic was significantly higher in the group with speech and language disorders compared to the families of the healthy group (p <0.05). During the pandemic, an increase in the use of television, tablets and computers was observed in the majority of children in both groups. In addition, families in both groups were found to have moderate/high levels of fear of transmission of the covid-19 virus to one of their families. Conclusion: It has been observed that the function and psycho-social impact of the Covid-19 pandemic on children with speech and language disorders and their families is similar to healthy children and their families. In particular, it has been observed that all families experience intense fear of transmission of the disease during this epidemic process, also have high levels of anxiety about future.

EFFECTS OF MELATONIN AND CURCUMIN TREATMENTS ON THE OVARIUM IN KIDNEY ISCHEMIA-REPERFUSION INJURY: A HISTOPATHOLOGICAL INVESTIGATION

Aim: We aimed to investigate how bilateral renal ischemia-reperfusion (I/R) damage affects the ovaries as a distant organ and the effects of melatonin (MEL), curcumin (CUR) and melatonin+curcumin (MEL+CUR) treatments on I/R damage. Material and Method: 42 female Wistar rats were used in the study. Rats were divided into 6 groups and study was designed as follows: Control group (G1) – opening and closing the abdomen only (sham surgery group) –, I/R group (G2) – 45 min ischemia followed by 2 h reperfusion –, I/R+MEL group (G3) – 45 min ischemia, intraperitoneal (i.p) 20 mg/kg MEL injection 5 min before reperfusion, followed by 2 h reperfusion –, I/R+CUR group (G4) – 45 min ischemia, 5 min before reperfusion i.p 200 mg/kg CUR injection and then 2 hours reperfusion –, I/R+MEL+CUR group (G5) – 45 min ischemia, 5 min before reperfusion i.p 20 mg/kg MEL and 200 mg/kg CUR injection, followed by 2 hours reperfusion –. At the end of the reperfusion period, the rats were sacrificed. Right ovaries were removed from the peritoneum and fixed. After fixation and follow-up, tissue sections were stained with hematoxylin&eosin (H&E), Periodic acid-Schiff (PAS)+Hematoxylin (PAS+H) and Masson’s trichrome stains. Pathological changes were scored and statistically evaluated. Results: Compared to the control group, there was a decrease in hemorrhage, vascular congestion, follicular degeneration, inflammation, interstitial edema, vasodilation and growing follicle numbers in all groups; these changes were severe in the G2 group; Mild to moderate severity was observed in the G3, G4 and G5 groups. Conclusion: Renal I/R damage significantly affects the ovaries histopathologically. MEL, CUR, and MEL+CUR partially preserve the histological structure, but MEL treatment seems to be more effective than CUR treatment.

THE RELATIONSHIP BETWEEN INFLAMMATION MARKERS AND MAGNESIUM/PHOSPHATE RATIO WITH ENDOTEL FUNCTION IN PERIPHERAL ARTERY DISEASE

Objective: In our study, it was aimed to evaluate the relationship between neutrophil/lymphocyte, monocyte/high-density lipoprotein and magnesium/phosphate ratios with endothelial functions in patients with peripheral artery disease. Methods: Sixty patients followed up with peripheral arterial disease were included in this study. Endothelial functions of the patients were evaluated by flow-mediated vasodilation test. Pearson correlation analysis was used to evaluate the relationship between magnesium/phosphate, neutrophil/lymphocyte, monocyte/high-density lipoprotein ratios with percent change in flow-mediated vasodilation. Results: 48.3% of the participants are male and 51.7% are female. The mean age of the patients were 66.85±11.08 years. The mean radial artery basal diameter was 0.24±0.02 cm in the flow-mediated vasodilatation test and after the test the mean radial artery diameter was 0.27±0.02 cm(p<0.001). In the flow-mediated dilatation test predicting endothelial functions, the percentage change in arterial diameter was positively correlated with the Magnesium/phosphate ratio (r=-0.326, p=0.011), and negatively correlated with the Neutrophil/lymphocyte ratio and monocyte/high-density lipoprotein ratio (respectively r= -0.411, p=0.001; r=-0.530, p=0.001). Conclusion: Magnesium/phosphate ratio, neutrophil/lymphocyte ratio and monocyte/high-density lipoprotein ratio can be used to predict endothelial dysfunction in patients with peripheral artery disease.

(A Clinicopathological Aspects of Resectable Pancreatic Neoplasm)

Aim Pancreatic cancer is one of the deadliest malignant neoplasms. As with many malignant neoplasms, survival rates depend on the histopathological type of cancer, its stage, tumor size, and treatment. In this study, we aimed to classify pancreatic cancer according to clinicopathological features and histological subtypes. Material and method The data of all adult patients diagnosed and treated for pancreatic neoplasm in our clinic were collected retrospectively from the hospital's computerized database and medical files. Patients were categorized according to their clinicopathological features. Chi-square test and Fisher's exact test were used for between-group comparisons, and t-test was used for independent samples for quantitative data. Data were expressed as mean ± SD for continuous variables and numbers and percentages for categorical variables. A value of p<0.05 was considered significant. Results The mean age of the patients was 60.5 years, 70.8% were male. There were five types of tumors defined histopathologically, and the most common diagnosis was adenocarcinoma (76.9%). The most common localization of the tumor was head and neck (44.4%). Whipple surgery was performed predominantly in 69.2% of patients, and distal pancreatectomy in 29.0%. Postoperative complications were observed in more than one third (34%) of the patients. The main complications were pancreatic cyst (16.3%). In the survival analysis performed with the Kaplan-Meier test, median survival of 30.5 months, and overall survival (OS) at 1.2 and 5 years were 67.8%, 40.5%, and 16.6%, respectively. Discussion However, survival analysis results were optimistic compared to population-based studies as all patients had resectable tumors.

Views of Physicians on the Persistence and Efficiency of Basic Medical Sciences Education

Introduction: In this study, it is aimed to contribute to the persistence of the basic medical sciences education given in medical faculties, how much it can be integrated into clinical science practices and to the development of education. Materials and Methods: The study was planned in a descriptive type and a questionnaire was applied to collect the data. The population of the study consisted of medical faculty graduates and there was no limitation in the selection of the sample. The level of agreement with the statements was graded from 1 to 5 with Likert-type scaling. In the study with a total of 205 participants, numbers and percentages were used for the data. Results: Of the physicians 59.5% stated that the basic medical sciences courses they took were not sufficient and permanent for their professional life, 69.74% of them stated that the course topics in basic medical sciences education are too detailed, 60.48% of them stated they could not integrate the education they received in basic medical sciences into clinical sciences, 82.91% stated that it would be more beneficial to give basic medicine and clinical medical sciences courses simultaneously, and 86.82% of them stated that the technology-adapted auxiliary course tools will increase the quality of basic medical education. Conclusion: In today's world where important developments are experienced in medical education, innovations are needed in order to train physicians in the best way. For this, it is necessary to work on a system in which basic medicine and clinical medical sciences are integrated, the course curriculum is revised and a strong technological infrastructure is provided.

AN INVESTIGATION OF EATING AWARENESS RISK FACTORS IN A DISTRICT FACULTY AND VOCATIONAL SCHOOL STUDENTS

AIM: This research was carried out to evaluate the awareness of eating in students studying at the college and to determine the factors affecting it. METHOD: This cross-sectional study, which was carried out in students of a district faculty and vocational school with 1750 students, was applied to 330 students face-to-face with a random sampling method. Eating awareness and affecting factors were examined and the factors examined by single analyzes were resolved by multiple linear regression. RESULTS: In the study group, 66.5% of whom were women and approximately half of them were in 1 class, the factors affecting eating awareness were found to be increased by not using alcohol, seeing the body as normal or weak and making applications to lose weight. In the study, it was determined that the awareness of eating classes, exercise, smoking status and anthropometric measurement differences did not affect eating awareness. CONCLUSION: Alcohol use and studies on improving the body perceptions of people should be done in applications aimed at increasing awareness of eating.

CLINICOPATHOLOGICAL EVALUATION OF SINONASAL REGION LESIONS: A SINGLE CENTER EXPERIENCE

Benign and malignant lesions of the sinonasal area are frequently seen in the clinic. The aim of this study was to evaluate the pathological and clinical features of patients diagnosed with sinonasal lesions in the Department of Pathology of the University of Health Sciences Ankara Training and Research Hospital between 2016 and 2019. Evaluation was made of benign and malignant sinonasal lesions reported in the Department of Pathology of the University of Health Sciences Ankara Training and Research Hospital between 2016 and 2019. The data including age, gender, diagnosis, localization and clinical information of patients diagnosed with benign and malignant sinonasal lesions were obtained retrospectively from the hospital information system and patient files. The data sets created were then evaluated statistically and the results were discussed in the light of the relevant literature. From the data sets obtained from the patient data, it was observed that the number of benign lesions in the sinonasal region (91%) was higher than malignant lesions (9%). Patients with sinonasal masses were predominantly in the 41-50 years age group, with a male to female ratio of 2:1. Rhinorrhea and nasal obstruction were determined to be the most common symptoms at presentation. The anatomic localization of the lesions sent to the pathology department was classified by the clinician, and reported as 84.5% nasal cavity, 3.5% nasal septum, 1.6% nasal concha, 2.2% nasal vestibule, and 8.2% paranasal sinus. According to the pathological diagnoses of these cases, sinonasal polyps with benign characteristics were found at the rate of 82.6%, and inverted papilloma with the potential for malignancy and recurrence at 8.5%. Sinonasal lesions are often benign but malignant potential should not be ignored. It should be kept in mind that benign and malignant lesions of this region may show similar symptoms and indications in clinical evaluation. Therefore, endoscopic and pathological evaluation is important for lesions detected in the sinonasal region.

The Effect of Gender and Body Image Satisfaction on Sexual Function in Patients with Head and Neck Cancer Treated with Radiotherapy/Chemoradiotherapy

Aims: The study was was conducted to determine the changes in sexual functions and the effect of gender and body image satisfaction on sexual function in patients with head and neck cancer who received radiotherapy or chemoradiotherapy after starting treatment. Methods: Forty three patients who underwent radiotherapy, radiotherapy (RT) or chemoradiotherapy (CRT) due to the diagnosis of head and neck cancer between October 2019 and March 2020 were included in the descriptive and correlational study. Research data were collected using the Structured Information Form, Arizona Sexual Experiences Scale and Body Image Satisfaction Scale at two different times, before and 6 weeks after the start of treatment. Results: Most of the patients participating in the study were male (55.8%) and married (74.4%). In the study, 69.8% of the patients had disease stages 1 and 2, and 65.1% of the patients had cancer in the pharynx and larynx. It was determined that 72.1% of the patients did not have a sexual problem before the diagnosis, and 90.7% of them had sexual problems after the diagnosis. There was a significant difference between the mean Arizona Sexual Experiences Scale scores of the patients before and after 6 weeks of RT/CRT (p<0.01); gender and Body Image Satisfaction Scale score significantly affected Arizona Sexual Experiences Scale score (R2=0.656, p<0.01). Conclusion: The treatment process in patients diagnosed with head and neck cancer undergoing RT/CRT causes sexual problems and worsening in sexual functions. Gender and body image satisfaction affect sexual function by 66%.

COVID-19 Phobia Of Emergency And Disaster Management Students

This study was conducted to examine the COVID-19 phobia situations experienced by students of the emergency and disaster management program during the COVID-19 outbreak. It is a descriptive study. The research was conducted with the voluntary participation of 92 students studying in Erzincan Binali Yıldırım University Health Services Vocational School of Emergency and Disaster Management program between 01-12 July 2020. The data were collected electronically via Google Forms using the “COVID-19 Phobia Scale”. Written approval was obtained from the Ministry of Health General Directorate of Health Services COVID-19 Scientific Research Evaluation Commission and Erzincan Binali Yıldırım University Human Research Ethics Committee. The evaluation of the data was done by using the SPSS package program on the computer, by frequency, chi-square test, t test and One-Way Anova tests. The average age of the students is 20.12 ± 0.99 years. It was determined that 63% of the students were girls, 43.5% had a low income level and only 4.3% had a chronic disease. The mean score of the students on the COVID-19 Phobia Scale is 51.63 ± 16.15. As a result, it was determined that the COVID-19 phobia levels of the students participating in the study were moderate. In addition, there are important differences between the COVID-19 test status and the COVID-19 phobia scale. In the study, although there were no significant differences in terms of some socio-demographic characteristics (gender, income level and chronic disease status) and COVID-19 phobia, the mean scores of girls, those with low income and those with chronic diseases were found to be high.

Comparison of Non-Tumescent n-Butyl Cyanoacrylate and Endovenous Laser Therapy in Saphenous Vein Ablation

Objective: Ablation of N-butyl cyanoacrylate (NBCA) and endovenous laser ablation (EVLA) are two important techniques used in the treatment of venous insufficiency. The aim of this study is to compare the results of EVLA and NBCA methods in the treatment of saphenous vein insufficiency. Method: 739 patients with saphenous vein insufficiency who were followed up between 2013 and 2018 and treated with NBCA (350 patients) and EVLA (389 patients) applications were included in the study. Pre-procedure, during, post-procedure and follow-up data of the patients were collected and compared retrospectively. Results: In the group using NBCA technique; mean age was 46.09±6.12 years, mean age was 48.08±6.11 years in the EVLA technique group. The mean ablated vein length was 32.97-65.83 cm in the NBCA group and 30.65-67.25 cm in the EVLA group. The mean procedure time was 7 minutes in the NBCA group and 18 minutes in the EVLA group. The 12-month total occlusion rates in the NBCA and EVLA groups were 98.8% and 97.6%, respectively. In both the NBCA and EVLA groups, the post-procedure Venous Clinical Severity Score (VCSS) was significantly reduced with no difference between the groups. When NBCA treatment was compared with EVLA treatment, it was seen that there may be fewer side effects after NBCA treatment. Conclusion: When the treatment success rates, application times, complication rates and venous clinical severity scoring results in the data obtained in our study were evaluated, it was thought that the NBCA method was as successful and reliable as the EVLA method. In conclusion; It has been suggested that the vascular closure system with NBCA is a fast and effective treatment method in the treatment of saphenous vein insufficiency, as it does not require tumescent anesthesia, does not require compression stockings, and does not have the risk of paresthesia, burn scars or pigmentation.