A case of squamous cell carcinoma of the right forearm with giant lymph node metastasis

Superficial thoracic esophageal cancer with a solitary metastasis to a lymph node outside the usual target area of lymphadenectomy is extremely rare. We report a case of superficial esophageal cancer with a solitary, giant metastasis to the right upper deep cervical lymph node that was treated with surgery. A 57-year-old man presented to our institution with a chief complaint of a mass in the right neck. Fine needle cytology showed squamous cell carcinoma. No lesion was found in the pharyngolaryngeal area or the lungs. Upper gastrointestinal endoscopy revealed superficial squamous cell carcinoma of the thoracic esophagus. Detailed examinations showed no other lymph node enlargement or metastasis to distant organs. The patient was diagnosed with esophageal cancer with a solitary lymph node metastasis (N4; No.102upR). Subtotal esophagectomy and 3-field lymphadenectomy were performed. The patient received adjuvant chemotherapy. At 3 years postsurgery, no recurrence has been found. We think this case is extremely rare.

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Faculty Opinions recommendation of Incidence of level IIB lymph node metastasis in supraglottic laryngeal squamous cell carcinoma with clinically negative neck--a prospective study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717597858.792952907 ◽

2012 ◽

Author(s):

Giulio Cantu ◽

Stefano Riccio ◽

Sarah Colombo

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Prospective Study ◽

Cell Carcinoma ◽

Squamous Cell ◽

Laryngeal Squamous Cell Carcinoma ◽

Node Metastasis ◽

A Prospective Study

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Identification of potential biomarkers of lymph node metastasis in oral squamous cell carcinoma by cDNA microarray analysis

International Journal of Cancer ◽

10.1002/ijc.11283 ◽

2003 ◽

Vol 106 (5) ◽

pp. 683-689 ◽

Cited By ~ 105

Author(s):

Masaki Nagata ◽

Hajime Fujita ◽

Hiroko Ida ◽

Hideyuki Hoshina ◽

Tatsuo Inoue ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Microarray Analysis ◽

Squamous Cell ◽

Cdna Microarray Analysis ◽

Node Metastasis ◽

Potential Biomarkers

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A nomogram to predict lymph node metastasis risk for early esophageal squamous cell carcinoma

BMC Cancer ◽

10.1186/s12885-021-08077-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Xiaofeng Duan ◽

Xiaobin Shang ◽

Jie Yue ◽

Zhao Ma ◽

Chuangui Chen ◽

...

Keyword(s):

Risk Factors ◽

Squamous Cell Carcinoma ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Early Stage ◽

Derivation Cohort ◽

Node Metastasis

Abstract Background A nomogram was developed to predict lymph node metastasis (LNM) for patients with early-stage esophageal squamous cell carcinoma (ESCC). Methods We used the clinical data of ESCC patients with pathological T1 stage disease who underwent surgery from January 2011 to June 2018 to develop a nomogram model. Multivariable logistic regression was used to confirm the risk factors for variable selection. The risk of LNM was stratified based on the nomogram model. The nomogram was validated by an independent cohort which included early ESCC patients underwent esophagectomy between July 2018 and December 2019. Results Of the 223 patients, 36 (16.1%) patients had LNM. The following three variables were confirmed as LNM risk factors and were included in the nomogram model: tumor differentiation (odds ratio [OR] = 3.776, 95% confidence interval [CI] 1.515–9.360, p = 0.004), depth of tumor invasion (OR = 3.124, 95% CI 1.146–8.511, p = 0.026), and tumor size (OR = 2.420, 95% CI 1.070–5.473, p = 0.034). The C-index was 0.810 (95% CI 0.742–0.895) in the derivation cohort (223 patients) and 0.830 (95% CI 0.763–0.902) in the validation cohort (80 patients). Conclusions A validated nomogram can predict the risk of LNM via risk stratification. It could be used to assist in the decision-making process to determine which patients should undergo esophagectomy and for which patients with a low risk of LNM, curative endoscopic resection would be sufficient.

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