Anti-apoptotic and antioxidant effects of melatonin protect spleen of whole body γ-irradiated male Sprague-dawley rats

Excess sympathetic nervous system activity (SNA) is linked to human essential and experimental hypertension. To test whether sympathetic activation is associated with a model of deoxycorticosterone acetate (DOCA)-salt hypertension featuring two kidneys and a moderate elevation of blood pressure, we measured whole body norepinephrine (NE) spillover as an index of global SNA. Studies were conducted in chronically catheterized male Sprague-Dawley rats drinking water containing 1% NaCl and 0.2% KCl. After a 7-day surgical recovery and a 3-day control period, a DOCA pellet (50 mg/kg) was implanted subcutaneously in one group of rats (DOCA), while the other group underwent sham implantation (Sham). NE spillover was measured on control day 2 and days 7 and 14 after DOCA administration or sham implantation. During the control period, mean arterial pressure (MAP) was similar in Sham and DOCA rats. MAP was significantly increased in the DOCA group compared with the Sham group after DOCA administration ( day 14: Sham = 109 ± 5.3, DOCA = 128 ± 3.6 mmHg). However, plasma NE concentration, clearance, and spillover were not different in the two groups at any time. To determine whether selective sympathetic activation to the kidneys contributes to hypertension development, additional studies were performed in renal denervated (RDX) and sham-denervated (Sham-DX) rats. MAP, measured by radiotelemetry, was similar in both groups during the control and DOCA treatment periods. In conclusion, global SNA is not increased during the development of mild DOCA-salt hypertension, and fully intact renal nerves are not essential for hypertension development in this model.

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Exercise training attenuates diet-induced reduction in metabolic rate

Journal of Applied Physiology ◽

10.1152/jappl.1990.68.6.2612 ◽

1990 ◽

Vol 68 (6) ◽

pp. 2612-2617 ◽

Cited By ~ 12

Author(s):

D. L. Ballor ◽

L. J. Tommerup ◽

D. P. Thomas ◽

D. B. Smith ◽

R. E. Keesey

Keyword(s):

Energy Expenditure ◽

Exercise Training ◽

Dietary Restriction ◽

Food Restriction ◽

Whole Body ◽

Daily Energy Expenditure ◽

Sprague Dawley ◽

Sprague Dawley Rats ◽

Daily Energy ◽

Whole Body Metabolism

The combined influence of exercise training and dietary restriction on daily energy expenditure was evaluated by exposing 48 male Sprague-Dawley rats to one of three food intake conditions [ad libitum (AL), moderately restricted (MR), or severely restricted (SR)] and to one of two exercise conditions [treadmill exercised (E) or cage confined (CC)]. After 10 wk of exercise and dietary restriction, the MR-CC and MR-E rats weighed 84 and 86%, respectively, of AL-CC, whereas the SR-CC and SR-E rats weighed 66 and 68% of AL-CC. Dietary restriction and subsequent weight loss produced significant reductions in both total and resting daily energy expenditure. Exercise partially reversed this effect, but the extent of this reversal diminished as the severity of dietary restriction was increased. These results raise the distinct possibility that inconsistencies in the current literature concerning the effects of exercise on whole body metabolism during periods of dietary restriction might be reconciled by an appreciation and an understanding of the influence that duration of exercise training and severity of food restriction have on this measure.

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Dietary leucine improves whole-body insulin sensitivity independent of body fat in diet-induced obese Sprague–Dawley rats

The Journal of Nutritional Biochemistry ◽

10.1016/j.jnutbio.2012.10.004 ◽

2013 ◽

Vol 24 (7) ◽

pp. 1285-1294 ◽

Cited By ~ 26

Author(s):

Lindsay K. Eller ◽

Dolan C. Saha ◽

Jane Shearer ◽

Raylene A. Reimer

Keyword(s):

Insulin Sensitivity ◽

Body Fat ◽

Whole Body ◽

Sprague Dawley ◽

Sprague Dawley Rats

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Antioxidant effects of the combination of conjugated linoleic acid and phytosterol supplementation in Sprague–Dawley rats

Food Research International ◽

10.1016/j.foodres.2012.07.022 ◽

2012 ◽

Vol 49 (1) ◽

pp. 487-493 ◽

Cited By ~ 14

Author(s):

Rafaela da Silva Marineli ◽

Anne y Castro Marques ◽

Cibele Priscila Busch Furlan ◽

Mário Roberto Maróstica

Keyword(s):

Linoleic Acid ◽

Conjugated Linoleic Acid ◽

Sprague Dawley ◽

Sprague Dawley Rats ◽

Antioxidant Effects

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Cholinergic and Antioxidant Effects of a Novel Neuroprotective Compound HAB16R26 Exposed in Sprague Dawley Rats

The Open Conference Proceedings Journal ◽

10.2174/2210289201304010159 ◽

2013 ◽

Vol 4 (1) ◽

pp. 159-159

Author(s):

Siti Norshazwani Wahab ◽

Kalavathy Ramasamy ◽

Abu Bakar Abdul Majeed ◽

Vasudevan Mani

Keyword(s):

Sprague Dawley ◽

Sprague Dawley Rats ◽

Antioxidant Effects

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Effects of Graded Doses of Whole-Body X-Irradiation on Mast Cells in the Rat Mesentery

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1956.187.1.160 ◽

1956 ◽

Vol 187 (1) ◽

pp. 160-162 ◽

Cited By ~ 9

Author(s):

F. P. Conte ◽

G. S. Melville ◽

A. C. Upton

Keyword(s):

Mast Cells ◽

Transient Increase ◽

Whole Body ◽

Sprague Dawley ◽

Rat Mesentery ◽

Sprague Dawley Rats ◽

X Irradiation ◽

Sublethal Doses

Male Sprague-Dawley rats were exposed to lethal and sublethal doses of x-radiation, and changes in the number of mast cells in the mesentery were correlated with dose and time postirradiation. After 75 r of whole-body x-radiation, a transient increase during the first 24 hours, followed by a slight decrease, in number of mast cells was observed. After larger doses of radiation (150–600 r), the mast cells were not seen to increase, but only to decrease in number during the first 2 weeks after exposure.

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Changes in respiratory timing induced by hypercapnia in maturing rats

Journal of Applied Physiology ◽

10.1152/jappl.1999.87.2.484 ◽

1999 ◽

Vol 87 (2) ◽

pp. 484-490 ◽

Cited By ~ 42

Author(s):

Jalal M. Abu-Shaweesh ◽

Ismail A. Dreshaj ◽

Agnes J. Thomas ◽

Musa A. Haxhiu ◽

Kingman P. Strohl ◽

...

Keyword(s):

Ventilatory Response ◽

Minute Ventilation ◽

Aminobutyric Acid ◽

Whole Body ◽

Sprague Dawley ◽

Newborn Rat ◽

Rat Pups ◽

Significant Prolongation ◽

Sprague Dawley Rats ◽

Central Origin

Premature infants respond to hypercapnia by an attenuated ventilatory response that is characterized by a decrease in respiratory frequency. We hypothesized that this impaired hypercapnic ventilatory response is of central origin and is mediated via γ-aminobutyric acid-ergic (GABAergic) pathways. We therefore studied two groups of maturing Sprague-Dawley rats: unrestrained rats in a whole body plethysmograph at four postnatal ages (5, 16–17, 22–23, and 41–42 days); and ventilated, decerebrate, vagotomized, paralyzed rats in which phrenic nerve responses to hypercapnia were measured at 4–6 and 37–39 days of age. In the unrestrained group, the increase in minute ventilation induced by hypercapnia was significantly lower at 5 days vs. beyond 16 days. Although there was an increase in tidal volume at all ages, frequency decreased significantly from baseline at 5 days, whereas it increased significantly at 16–17, 22–23, and 41–42 days. The decrease in frequency at 5 days of age was mainly due to a significant prolongation in expiratory duration (Te). In the ventilated group, hypercapnia also caused prolongation in Te at 4–6 days but not at 37–39 days of age. Intravenous administration of bicuculline (GABAA-receptor blocker) abolished the prolongation of Te in response to hypercapnia in the newborn rats. We conclude that newborn rat pups exhibit a characteristic ventilatory response to CO2 expressed as a centrally mediated prolongation of Te that appears to be mediated by GABAergic mechanisms.

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