Suppressive Effect of Extractive from Leaves of Morus alba with α-Glucosidase Inhibitors on Human Postprandial Blood Glucose Elevation Induced by Starchy Foods

Inhibiting starch hydrolysis into sugar could reduce postprandial blood glucose elevation and contribute to diabetes prevention. Here, both buckwheat and wheat albumin that inhibited mammalian α-amylase in vitro suppressed blood glucose level elevation after starch loading in vivo, but it had no effect after glucose loading. In contrast to the non-competitive inhibition of wheat α-amylase inhibitor, buckwheat albumin acted in a competitive manner. Although buckwheat α-amylase inhibitor was readily hydrolysed by digestive enzymes, the hydrolysate retained inhibitory activity. Together with its thermal stability, this suggests its potential use in functional foods that prevent diabetes.

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Suppressive effect of a single dose of monoglucosyl rutin on postprandial blood glucose elevation: A randomized, placebo-controlled, double-blind crossover study

Functional Foods in Health and Disease ◽

10.31989/ffhd.v11i6.793 ◽

2021 ◽

Vol 11 (6) ◽

pp. 270

Author(s):

Yushi Hashizume ◽

Mahamadou Tandia

Keyword(s):

Blood Glucose ◽

Crossover Study ◽

Fasting Blood Glucose ◽

Area Under The Curve ◽

Suppressive Effect ◽

Postprandial Blood Glucose ◽

Double Blind ◽

Blood Glucose Elevation ◽

Blind Crossover Study ◽

Double Blind Crossover Study

Objective: This study aimed to investigate the suppressive effect of a single dose of water-soluble α- glycosylated rutin (monoglucosyl rutin; MR) on postprandial blood glucose elevation in healthy subjects with relatively high fasting blood glucose levels.Methods: This randomized, placebo-controlled, double-blind crossover study enrolled 34 healthy Japanese adult subjects with relatively high fasting blood glucose levels. The study period ran from November 13, 2019, to March 19, 2020. All subjects were randomly allocated to either sequence A or sequence B (n = 17 per group) using a computerized random number generator. The washout period was at least one week between periods I and II. In period I, the subjects took either MR or placebo tablets. In period II, subjects took different tablets from the ones they had taken in period I. We evaluated their blood glucose and insulin levels after glucose loading (150 g of cooked rice). The incremental area under the curve (IAUC) of the postprandial blood glucose level was determined as the primary outcome. The blood glucose and insulin levels at maximum (maximum blood concentration; Cmax), each measurement point, and IAUC of the blood insulin level after glucose loading were the secondary outcomes.Results: Out of 33 subjects, 16 in sequence A (11 men and 5 women, 54.5 ± 9.8 years) and 17 in sequence B (9 men and 8 women, 58.8 ± 9.4 years) were analyzed as a per-protocol dataset. The glucose IAUC after MR consumption was significantly lower than that of the placebo (P = 0.034). Results of the other outcomes were not observed with significant treatment effects. There were no adverse events attributable to the test foods.Conclusions: We suggest that MR has a suppressive effect on the elevation of postprandial blood glucose in healthy adults with relatively high fasting blood glucose levels.Trial registration: UMIN-CTR: UMIN000038515. Foundation: Toyo Sugar Refining Co., Ltd.Keywords: monoglucosyl rutin, blood glucose level, incremental area under the curve, α-amylase, α-glucosidase, crossover study

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Lemongrass (Cymbopogon citratus) Ethanolic Extract Exhibited Activities That Inhibit -glucosidase Enzymes and Postprandial Blood Glucose Elevation

Makara Journal of Science ◽

10.7454/mss.v24i4.1154 ◽

2020 ◽

Vol 24 (4) ◽

Keyword(s):

Blood Glucose ◽

Ethanolic Extract ◽

Postprandial Blood Glucose ◽

Cymbopogon Citratus ◽

Blood Glucose Elevation

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Skin-related enzyme inhibitory activity by hydrolyzable polyphenols in water chestnut (Trapa natans) husk

Bioscience Biotechnology and Biochemistry ◽

10.1093/bbb/zbaa076 ◽

2021 ◽

Vol 85 (3) ◽

pp. 666-674

Author(s):

Midori Yasuda ◽

Masaki Ikeoka ◽

Shin-ichi Kondo

Keyword(s):

Suppressive Effect ◽

Postprandial Blood Glucose ◽

Water Chestnut ◽

Trapa Natans ◽

Related Enzyme ◽

Inhibitory Activities ◽

Blood Glucose Elevation ◽

Lifestyle Related Diseases ◽

The Devil ◽

Floating Leaf

ABSTRACT Water chestnut is a floating leaf plant native to Asia and Europe. Its fruit has long been used as an edible and herbal medicine. Water chestnut contains many polyphenols and its consumption can prevent lifestyle-related diseases because it has a suppressive effect on postprandial blood glucose elevation; however, its suitability as a cosmetic material is unknown. Therefore, this study aimed at investigating the antiaging effect of polyphenols contained in the husk of the devil water chestnut (Trapa natans). Six hydrolyzable polyphenols—1,6-di-O-galloyl-β-d-glucopyranose, 1,2,6-tri-O-galloyl-β-d-glucopyranose, 1,6-di-O-galloyl-2,3-O-(S)-hexahydroxydiphenoyl-β-d-glucopyranose (nobotanin D), eugeniin, 1,2,3,6-tetra-O-galloyl-β-d-glucopyranose, and trapain—were collected and isolated from the water chestnut husk. These polyphenols showed high antioxidant and antiglycation activities. In addition, inhibitory activities against hyaluronidase, elastase, and collagenase were observed. Especially, eugeniin and trapain, which have many gallic acids and a hexahydroxy-biphenyl group, showed high inhibitory activities. Thus, the polyphenols in water chestnut are beneficial for antiaging effects.

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