Skin-related enzyme inhibitory activity by hydrolyzable polyphenols in water chestnut (Trapa natans) husk

2021 ◽  
Vol 85 (3) ◽  
pp. 666-674
Author(s):  
Midori Yasuda ◽  
Masaki Ikeoka ◽  
Shin-ichi Kondo
Keyword(s):  
Suppressive Effect ◽  
Postprandial Blood Glucose ◽  
Water Chestnut ◽  
Trapa Natans ◽  
Related Enzyme ◽  
Inhibitory Activities ◽  
Blood Glucose Elevation ◽  
Lifestyle Related Diseases ◽  
The Devil ◽  
Floating Leaf

ABSTRACT Water chestnut is a floating leaf plant native to Asia and Europe. Its fruit has long been used as an edible and herbal medicine. Water chestnut contains many polyphenols and its consumption can prevent lifestyle-related diseases because it has a suppressive effect on postprandial blood glucose elevation; however, its suitability as a cosmetic material is unknown. Therefore, this study aimed at investigating the antiaging effect of polyphenols contained in the husk of the devil water chestnut (Trapa natans). Six hydrolyzable polyphenols—1,6-di-O-galloyl-β-d-glucopyranose, 1,2,6-tri-O-galloyl-β-d-glucopyranose, 1,6-di-O-galloyl-2,3-O-(S)-hexahydroxydiphenoyl-β-d-glucopyranose (nobotanin D), eugeniin, 1,2,3,6-tetra-O-galloyl-β-d-glucopyranose, and trapain—were collected and isolated from the water chestnut husk. These polyphenols showed high antioxidant and antiglycation activities. In addition, inhibitory activities against hyaluronidase, elastase, and collagenase were observed. Especially, eugeniin and trapain, which have many gallic acids and a hexahydroxy-biphenyl group, showed high inhibitory activities. Thus, the polyphenols in water chestnut are beneficial for antiaging effects.

scholarly journals Suppressive Effect of the α-Amylase Inhibitor Albumin from Buckwheat (Fagopyrum esculentum Moench) on Postprandial Hyperglycaemia

Nutrients ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1503 ◽  
Author(s):  
Kazumi Ninomiya ◽  
Shigenobu Ina ◽  
Aya Hamada ◽  
Yusuke Yamaguchi ◽  
Makoto Akao ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Competitive Inhibition ◽  
Suppressive Effect ◽  
Postprandial Blood Glucose ◽  
Amylase Inhibitor ◽  
Level Elevation ◽  
Fagopyrum Esculentum Moench ◽  
Blood Glucose Elevation

Inhibiting starch hydrolysis into sugar could reduce postprandial blood glucose elevation and contribute to diabetes prevention. Here, both buckwheat and wheat albumin that inhibited mammalian α-amylase in vitro suppressed blood glucose level elevation after starch loading in vivo, but it had no effect after glucose loading. In contrast to the non-competitive inhibition of wheat α-amylase inhibitor, buckwheat albumin acted in a competitive manner. Although buckwheat α-amylase inhibitor was readily hydrolysed by digestive enzymes, the hydrolysate retained inhibitory activity. Together with its thermal stability, this suggests its potential use in functional foods that prevent diabetes.

scholarly journals Inhibitory effects of polyphenols from water chestnut (Trapa japonica) husk on glycolytic enzymes and postprandial blood glucose elevation in mice

2014 ◽  
Vol 165 ◽  
pp. 42-49 ◽  
Author(s):  
Midori Yasuda ◽  
Kenichiro Yasutake ◽  
Madoka Hino ◽  
Hitomi Ohwatari ◽  
Nozomi Ohmagari ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Glycolytic Enzymes ◽  
Postprandial Blood Glucose ◽  
Inhibitory Effects ◽  
Water Chestnut ◽  
Blood Glucose Elevation

scholarly journals Inhibitory Effect of Tangeretin and Cardamonin on Human Intestinal SGLT1 Activity In Vitro and Blood Glucose Levels in Mice In Vivo

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3382
Author(s):  
Hideo Satsu ◽  
Ryosuke Shibata ◽  
Hiroto Suzuki ◽  
Shimon Kimura ◽  
Makoto Shimizu
Keyword(s):  
Blood Glucose ◽  
Inhibitory Effect ◽  
Postprandial Blood Glucose ◽  
Oral Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Blood Glucose Elevation ◽  
Lifestyle Related Diseases

Rapid postprandial blood glucose elevation can cause lifestyle-related diseases, such as type II diabetes. The absorption of food-derived glucose is primarily mediated by sodium/glucose cotransporter 1 (SGLT1). Moderate SGLT1 inhibition can help attenuate postprandial blood glucose elevation and prevent lifestyle-related diseases. In this study, we established a CHO cell line stably expressing human SGLT1 and examined the effects of phytochemicals on SGLT1 activity. Among the 50 phytochemicals assessed, tangeretin and cardamonin inhibited SGLT1 activity. Tangeretin and cardamonin did not affect the uptake of L-leucine, L-glutamate, and glycyl-sarcosine. Tangeretin, but not cardamonin, inhibited fructose uptake, suggesting that the inhibitory effect of tangeretin was specific to the monosaccharide transporter, whereas that of cardamonin was specific to SGLT1. Kinetic analysis suggested that the suppression of SGLT1 activity by tangeretin was associated with a reduction in Vmax and an increase in Km, whereas suppression by cardamonin was associated with a reduction in Vmax and no change in Km. Oral glucose tolerance tests in mice showed that tangeretin and cardamonin significantly suppressed the rapid increase in blood glucose levels. In conclusion, tangeretin and cardamonin were shown to inhibit SGLT1 activity in vitro and lower blood glucose level in vivo.

scholarly journals Suppressive effect of a single dose of monoglucosyl rutin on postprandial blood glucose elevation: A randomized, placebo-controlled, double-blind crossover study

2021 ◽  
Vol 11 (6) ◽  
pp. 270
Author(s):  
Yushi Hashizume ◽  
Mahamadou Tandia
Keyword(s):  
Blood Glucose ◽  
Crossover Study ◽  
Fasting Blood Glucose ◽  
Area Under The Curve ◽  
Suppressive Effect ◽  
Postprandial Blood Glucose ◽  
Double Blind ◽  
Blood Glucose Elevation ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

Objective: This study aimed to investigate the suppressive effect of a single dose of water-soluble α- glycosylated rutin (monoglucosyl rutin; MR) on postprandial blood glucose elevation in healthy subjects with relatively high fasting blood glucose levels.Methods: This randomized, placebo-controlled, double-blind crossover study enrolled 34 healthy Japanese adult subjects with relatively high fasting blood glucose levels. The study period ran from November 13, 2019, to March 19, 2020. All subjects were randomly allocated to either sequence A or sequence B (n = 17 per group) using a computerized random number generator. The washout period was at least one week between periods I and II. In period I, the subjects took either MR or placebo tablets. In period II, subjects took different tablets from the ones they had taken in period I. We evaluated their blood glucose and insulin levels after glucose loading (150 g of cooked rice). The incremental area under the curve (IAUC) of the postprandial blood glucose level was determined as the primary outcome. The blood glucose and insulin levels at maximum (maximum blood concentration; Cmax), each measurement point, and IAUC of the blood insulin level after glucose loading were the secondary outcomes.Results: Out of 33 subjects, 16 in sequence A (11 men and 5 women, 54.5 ± 9.8 years) and 17 in sequence B (9 men and 8 women, 58.8 ± 9.4 years) were analyzed as a per-protocol dataset. The glucose IAUC after MR consumption was significantly lower than that of the placebo (P = 0.034). Results of the other outcomes were not observed with significant treatment effects. There were no adverse events attributable to the test foods.Conclusions: We suggest that MR has a suppressive effect on the elevation of postprandial blood glucose in healthy adults with relatively high fasting blood glucose levels.Trial registration: UMIN-CTR: UMIN000038515. Foundation: Toyo Sugar Refining Co., Ltd.Keywords: monoglucosyl rutin, blood glucose level, incremental area under the curve, α-amylase, α-glucosidase, crossover study

Drying and rehydration characteristics of water chestnut (Trapa natans) as a function of drying air temperature

2008 ◽  
Vol 87 (2) ◽  
pp. 213-221 ◽  
Author(s):  
Gagan Deep Singh ◽  
Rajiv Sharma ◽  
A.S. Bawa ◽  
D.C. Saxena
Keyword(s):  
Air Temperature ◽  
Water Chestnut ◽  
Trapa Natans
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