Can pancreatic cancer be detected by adrenomedullin in patients with new-onset diabetes? The PaCANOD cohort study protocol

2018 ◽  
Vol 104 (4) ◽  
pp. 312-314 ◽  
Author(s):  
Laura Antolino ◽  
Mara La Rocca ◽  
Federico Todde ◽  
Elena Catarinozzi ◽  
Paolo Aurello ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Early Diagnosis ◽  
Screening Tools ◽  
Cancer Development ◽  
Exclusion Criteria ◽  
Onset Diabetes ◽  
Registration Number ◽  
Risk Patients ◽  
New Onset

Introduction: Pancreatic cancer is a leading cause of cancer-related death. Its diagnosis is often delayed and patients are frequently found to have unresectable disease. Patients diagnosed with new-onset diabetes have an 8-fold risk of harboring pancreatic cancer. Adrenomedullin has been claimed to mediate diabetes in pancreatic cancer. New screening tools are needed to develop an early diagnosis protocol. Methods: Patients aged 45-75 years within 2 years of first fulfilling the ADA criteria for diabetes will be prospectively enrolled in this study. Sepsis, renal failure, microangiopathy, pregnancy, acute heart failure and previous malignancies will be considered as exclusion criteria. Results: 440 patients diagnosed with new-onset diabetes will be enrolled and divided into 2 groups: one with high adrenomedullin levels and one with low adrenomedullin levels. Patients will undergo 3 years’ follow-up to detect pancreatic cancer development. Conclusions: Identifying a marker for pancreatic cancer among high-risk patients such as new-onset diabetics might lead to the identification of a subpopulation needing to be screened in order to enable early diagnosis and treatment of a highly lethal tumor. Trial registration: This trial was registered at ClinicalTrials.gov on May 25, 2015 under registration number NCT02456051.

New‐onset Diabetes as a Harbinger of Pancreatic Cancer: is Early Diagnosis Possible?

2021 ◽  
pp. 409-417
Author(s):  
Dana K. Andersen ◽  
Suresh T. Chari ◽  
Eithne Costello ◽  
Tatjana Crnogorac‐Jurcevic ◽  
Phil A. Hart ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Early Diagnosis ◽  
Onset Diabetes ◽  
New Onset

scholarly journals New-onset diabetes: a potential clue to the early diagnosis of pancreatic cancer

2009 ◽  
Vol 10 (1) ◽  
pp. 88-95 ◽  
Author(s):  
Rahul Pannala ◽  
Ananda Basu ◽  
Gloria M Petersen ◽  
Suresh T Chari
Keyword(s):  
Pancreatic Cancer ◽  
Early Diagnosis ◽  
Onset Diabetes ◽  
New Onset

W1399 Pancreatic Cyst, Not New-Onset Diabetes, Is the Clue to Early Diagnosis of Pancreatic Cancer

2008 ◽  
Vol 134 (4) ◽  
pp. A-696
Author(s):  
Yousuke Nakai ◽  
Minoru Tada ◽  
Yoko Yashima ◽  
Hiroshi Yagioka ◽  
Hirofumi Kogure ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Early Diagnosis ◽  
Pancreatic Cyst ◽  
Onset Diabetes ◽  
New Onset

Abstract 658: New Onset Diabetes Does Not Pose Additional Risk - Analysis Of 15,111 Treated Hypertensive Patients With 40 Year Follow-up.

Hypertension ◽  
2014 ◽  
Vol 64 (suppl_1) ◽  
Author(s):  
Stefanie Lip
Keyword(s):  
Alkaline Phosphatase ◽  
Hospital Admissions ◽  
Cox Proportional Hazards ◽  
Outcome Analysis ◽  
Gamma Glutamyl Transpeptidase ◽  
Hypertensive Patients ◽  
Onset Diabetes ◽  
Diabetes Status ◽  
New Onset

Objective: It is unclear whether new onset diabetes (NOD) is a separate entity associated with excess risk in hypertensive patients. Methods: We studied 15111 hypertensive patients with up to 40 year follow-up at the Glasgow BP Clinic database. Diabetes status was defined based on hospital admissions for any diabetes related diagnosis or prescription of anti-diabetic drugs or diabetes monitoring materials. The date at first hospital encounter either for prescription or admission was considered as the onset of diabetes. NOD was classified into early and late (diagnosis <10yrs or >10years from first clinic visit). Cause-specific outcome analysis was performed using multivariate-adjusted Cox proportional hazards (Cox-PH) models. In order to address any potential competing risk introduced due to the long follow-up period, an additional composite end point of all-cause mortality+NOD was analysed. Results: There were 2521(17%) patients with DM, of whom 2061(14%) had NOD. The incidence rate of NOD was 9.2 per 1000 person-years. Prevalence of early NOD was 898 (6%) and late NOD 1163 (8%). The total time at risk was 239,952 person-years with a median survival time of 28.04 years (IQR: 16.24-39.95). There were 5225 deaths (52% from cardiovascular causes) during the follow-up period. Independent predictors of new-onset diabetes in order of decreasing significance were baseline glucose, BMI, age, alanine transaminase, alkaline phosphatase, gamma glutamyl transpeptidase and bilirubin. Of these age, glucose, BMI and alkaline phosphatase remained top predictors for the composite outcome of NOD+all-cause death. The mortality risk was the highest in those with prevalent DM (HR=1.5[95%CI=1.2;1.9]) and lowest in those with late NOD (0.79[0.68;0.92]). Early NOD and non-diabetic subjects had similar risks. Conclusions: Indices of liver function tests predict the risk of NOD and mortality in addition to BMI and baseline glucose. The risk posed by NOD is related to duration of diabetes primarily indicating the importance of efforts to delay onset of NOD.

scholarly journals Serum metabolomics differentiating pancreatic cancer from new-onset diabetes

Oncotarget ◽  
2017 ◽  
Vol 8 (17) ◽  
pp. 29116-29124 ◽  
Author(s):  
Xiangyi He ◽  
Jie Zhong ◽  
Shuwei Wang ◽  
Yufen Zhou ◽  
Lei Wang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Onset Diabetes ◽  
Serum Metabolomics ◽  
New Onset

U-shaped Association Between Dietary Zinc Intake and New-onset Diabetes: A Nationwide Cohort Study in China

2021 ◽  
Author(s):  
Panpan He ◽  
Huan Li ◽  
Mengyi Liu ◽  
Zhuxian Zhang ◽  
Yuanyuan Zhang ◽  
...  
Keyword(s):  
Chinese Adults ◽  
Dietary Zinc ◽  
Nutrition Survey ◽  
Zinc Intake ◽  
Health And Nutrition ◽  
Onset Diabetes ◽  
Household Food Inventory ◽  
Diagnosed Diabetes ◽  
New Onset

Abstract Aims We aimed to investigate the relationship of dietary zinc intake with new-onset diabetes among Chinese adults. Materials and Methods A total of 16 257 participants who were free of diabetes at baseline from the China Health and Nutrition Survey were included. Dietary intake was measured by 3 consecutive 24-hour dietary recalls combined with a household food inventory. Participants with self-reported physician-diagnosed diabetes, or fasting glucose ≥ 7.0 mmol/L, or glycated hemoglobin ≥ 6.5% during the follow-up were defined as having new-onset diabetes. Results A total of 1097 participants developed new-onset diabetes during a median follow-up duration of 9.0 years. Overall, the association between dietary zinc intake and new-onset diabetes followed a U-shape (P for nonlinearity &lt; 0.001). The risk of new-onset diabetes was significantly lower in participants with zinc intake &lt; 9.1 mg/day (per mg/day: hazard ratio [HR], 0.73; 95% CI, 0.60-0.88), and higher in those with zinc intake ≥ 9.1 mg/day (per mg/day: HR, 1.10; 95% CI, 1.07-1.13). Consistently, when dietary zinc intake was assessed as deciles, compared with those in deciles 2-8 (8.9 -&lt;12.2 mg/day), the risk of new-onset diabetes was higher for decile 1 (&lt;8.9 mg/day: HR, 1.29; 95% CI, 1.04-1.62), and deciles 9 to 10 (≥12.2 mg/day: HR, 1.62; 95% CI, 1.38-1.90). Similar U-shaped relations were found for plant-derived or animal-derived zinc intake with new-onset diabetes (all P for nonlinearity &lt; 0.001). Conclusions There was a U-shaped association between dietary zinc intake and new-onset diabetes in general Chinese adults, with an inflection point at about 9.1 mg/day.

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