Ocular Inserts – A Potential Ocular Controlled Drug Delivery Systems

Ophthalmic drug delivery is one of the most exciting and difficult areas of research for pharmaceutical scientists. The eye's anatomy, physiology, and biochemistry render it impenetrable to outside chemicals. The capacity to maintain a therapeutic level of the drug at the site of action for an extended period of time is a significant hurdle in ocular therapy. The ocular insert represents a substantial development in the treatment of eye illness by extending the duration of the therapeutic level of the medicine at the site of action. They are constructed of a polymeric matrix that may or may not contain a pharmaceutical agent. The medicine can then be introduced into the polymeric support as a dispersion or solution. They have a number of advantages, including increased ocular residence and prolonged pharmaceutical release into the eye. The insert is composed of a body component that is tailored to fit within the eyelid's lachrymal canaliculus. The inserts are classed as insoluble, soluble, or bioerodible based on their solubility. The drug is released from the insert by diffusion, osmosis, and bioerosion. This review aimed to provide a brief overview of Ocular Inserts – A Potential Ocular Controlled Drug Delivery Systems.

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A REVIEW ON MICROSPHERES AS A NOVEL CONTROLLED DRUG DELIVERY SYSTEM

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2021.v14i4.40634 ◽

2021 ◽

pp. 3-11

Author(s):

MOUSAMI S SAMANTA ◽

DEEPAK GAUTAM ◽

MUHAMMED WASIM CHANDEL ◽

GAURANG SAWANT ◽

KIRTI SHARMA

Keyword(s):

Drug Delivery ◽

Plasma Concentration ◽

Patient Compliance ◽

Drug Delivery Systems ◽

Controlled Drug Delivery ◽

Extended Period ◽

Delivery Systems ◽

Therapeutic Drug ◽

Conventional Drug ◽

Drug Plasma

Over the past three decades, controlled drug delivery systems have become more developed and play a key role in pharmaceuticals formulations. There are many shortcomings in Traditional or Conventional drug delivery systems like for maintaining desired therapeutic drug plasma concentration there is a need for frequent dosing for particular drugs having shorter half-lives. Furthermore, because of frequent dosing requirement, there is poor patient compliance which causes fluctuation in plasma concentration of the drug. The limitations of conventional drug delivery can be overcome by the development of novel drug delivery systems, of which the controlled drug delivery can maintain constant drug plasma concentration by slowly releasing the drug over an extended period. Developing controlled drug delivery systems can also improve the systemic bioavailability of the drug, thus enhancing the therapeutic efficacy of the drug and better patient compliance. There are many different approaches for such controlled delivery systems such as liposomes, niosomes, ethosomes, phytosomes, microemulsion, and microspheres. Among all the approaches microspheres are more convenient as the drug is slowly released from the polymeric matrix and the polymers used are mostly biodegradable and possess no side effects. Therefore, microspheres can be used in various medicinal departments such as oncology, gynecology, radiology, pulmonary, cardiology, diabetes, and vaccine therapy. This review article focuses on recent different types of microspheres along with their methods of preparation. The microspheres formulated can be later evaluated and characterized by different procedures.

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