Regional Nodal Metastasis of Humeral Chondrosarcoma in a Dog

2015 ◽  
Vol 51 (5) ◽  
pp. 346-351 ◽  
Author(s):  
Mandy Meindel ◽  
Lisa Pohlman ◽  
Brad DeBey ◽  
Mary Lynn Higginbotham ◽  
Rachel Moon
Keyword(s):  
Lymph Nodes ◽  
Histopathological Examination ◽  
Bone Lesion ◽  
Prognostic Indicator ◽  
Needle Aspiration ◽  
Nodal Metastasis ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
History Of ◽  
The Right

A 6 yr old castrated male English springer spaniel was evaluated with a 1 mo history of progressive right forelimb lameness with recent swelling around the elbow joint. Physical examination findings included lameness of the right forelimb, muscle atrophy around the right shoulder, grade 2/6 heart murmur, and moderate dental disease. Results of a complete blood cell count and serum biochemical analysis were unremarkable with the exception of a mildly increased alkaline phosphatase (368 U/L; reference range, 128–328 U/L). Radiographs of the right elbow revealed a mixed lytic and proliferative osseous lesion most consistent with either neoplasia or infection. Thoracic radiographs and the echocardiogram were unremarkable. Fine-needle aspiration of the bone lesion was performed. The cytological diagnosis was chondrosarcoma. The right forelimb was amputated and the axillary lymph nodes were collected. Histopathological examination of the bone lesion and axillary lymph nodes revealed chondrosarcoma with metastasis to the lymph nodes. Lymph node metastasis of chondrosarcoma is rare and needs to be further evaluated as a prognostic indicator.

Ocular non-teratoid medulloepithelioma with teratoid metastases in ipsilateral intraparotid lymph nodes

2019 ◽  
pp. 112067211987007
Author(s):  
Jayati Sarangi ◽  
Aanchal Kakkar ◽  
Diya Roy ◽  
Rishikesh Thakur ◽  
Chirom Amit Singh ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Histopathological Examination ◽  
Previous History ◽  
Rare Presentation ◽  
Cervical Lymph Nodes ◽  
Extranodal Extension ◽  
Positron Emission ◽  
Parotid Neoplasm ◽  
History Of ◽  
The Right

Purpose: To describe a rare presentation of a case of intraocular non-teratoid medulloepithelioma with teratoid metastases in ipsilateral intraparotid lymph nodes. Case description: A 9-year-old male child with previous history of ciliary body non-teratoid medulloepithelioma presented with a swelling in the right pre-auricular region for 1 month. Magnetic resonance imaging and positron emission tomography–computed tomography showed a right intraparotid mass with enlarged ipsilateral cervical lymph nodes. A core biopsy was taken from the lesion, which on microscopy showed a tumor composed of small round cells arranged in cords, tubules lined by multilayered cells, and in cribriform pattern. These cells were embedded in a hypocellular, loose myxoid matrix. Based on the histopathological characteristics and previous history, a diagnosis of medulloepithelioma metastastic to ipsilateral parotid gland was made. The patient underwent right total conservative parotidectomy and bilateral neck dissection. Histopathological examination revealed metastatic medulloepithelioma in five out of eight intraparotid lymph nodes, with extranodal extension into the adjacent parotid parenchyma. Foci of hyaline cartilage were identified within the tumor, leading to a diagnosis of metastatic teratoid medulloepithelioma. Conclusion: Intraparotid lymph node metastases from intraocular medulloepithelioma is a rare possibility and we recommend that the parotid should be evaluated in cases of intraocular medulloepithelioma at initial presentation as well as during the follow-up period. Also, metastasis should be considered in all pediatric patients with solitary mass lesions showing unconventional histology for a primary parotid neoplasm.

scholarly journals Evolutionary history of metastatic breast cancer reveals minimal seeding from axillary lymph nodes

2018 ◽  
Vol 128 (4) ◽  
pp. 1355-1370 ◽  
Author(s):  
Ikram Ullah ◽  
Govindasamy-Muralidharan Karthik ◽  
Amjad Alkodsi ◽  
Una Kjällquist ◽  
Gustav Stålhammar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Nodes ◽  
Evolutionary History ◽  
Metastatic Breast ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
History Of

Passive and specific targeting of lymph nodes: the influence of the administration route

2015 ◽  
Vol 7 (2) ◽  
Author(s):  
Marion Pitorre ◽  
Guillaume Bastiat ◽  
Elodie Marie dit Chatel ◽  
Jean-Pierre Benoit
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Injection Site ◽  
Lymph Flow ◽  
Axillary Lymph Nodes ◽  
Optimal Size ◽  
Axillary Lymph ◽  
Left And Right ◽  
The Right ◽  
Weak Accumulation

AbstractPatients diagnosed with an advanced-stage cancer present a dismal prognosis due to the presence of metastases. From the primary tumor, the cancer cells are disseminated via lymphatic circulation; metastases develop initially in lymph nodes. Therefore, the targeting of lymph nodes needs to be improved in the design of future chemotherapy, and one way to ensure this targeting is by using the subcutaneous (SC) route. Using lipid nanocapsules (LNCs) (40 nm and fluorescently-labeled with DiD) as nanocarriers, a correlation between the SC injection site (behind the neck, the right and left flanks, and above the tail) for LNC administration and specific lymph node accumulation (left and right cervical, axillary and inguinal lymph nodes) was achieved for Sprague-Dawley rats. The pharmacokinetic and biodistribution profiles confirmed the absence of LNCs in systemic circulation after SC administration due to the optimal size of the LNCs. With appropriate SC administration, LNCs can accumulate in specific lymph nodes, whereas IV administration led to a weak accumulation of LNCs in all lymph nodes. Specific accumulation followed the lymph flow: bottom-up from the lower to upper limbs and top down from the head, with two lymph circulation partitions: right upper limb and the rest. Administration above the tail presented high inguinal and axillary lymph node accumulation whereas weak accumulation was observed after administration behind the neck. LNCs administered in the left flank only accumulated in the left inguinal and axillary lymph nodes, whereas left and right inguinal and axillary lymph nodes presented accumulation after administration in the right flank. Cervical lymph nodes, in the opposite direction of lymph flow, were never targeted after SC administration, whatever the injection site.

scholarly journals Role of ultrasound-guided fine-needle aspiration of indeterminate and suspicious axillary lymph nodes in the initial staging of breast carcinoma

Cancer ◽  
2002 ◽  
Vol 95 (5) ◽  
pp. 982-988 ◽  
Author(s):  
Savitri Krishnamurthy ◽  
Nour Sneige ◽  
Deepak G. Bedi ◽  
Beth S. Edieken ◽  
Bruno D. Fornage ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Lymph Nodes ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Ultrasound Guided ◽  
Fine Needle ◽  
Initial Staging

Nonimage-Guided Fine Needle Aspiration Biopsy of Palpable Axillary Lymph Nodes in Breast Cancer Patients

2011 ◽  
Vol 18 (1) ◽  
pp. 3-7 ◽  
Author(s):  
Jennifer L. Marti ◽  
Diego Ayo ◽  
Pascale Levine ◽  
Osvaldo Hernandez ◽  
John Rescigno ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Biopsy ◽  
Needle Aspiration ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Breast Cancer Patients ◽  
Fine Needle
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