Skull Base Primary Extracranial Meningioma with Hyperostosis in a Small Mixed-Breed Dog

Author(s):  
Joshua Samuel Montel ◽  
Arathi Vinayak ◽  
Jin Heo ◽  
E. J. Ehrhart

ABSTRACT A 7 yr old female spayed Chihuahua-terrier mix was presented for a progressive dry, hacking cough over 9 mo, with dyspnea aggravated by eating and drinking. Computed tomography of the skull revealed a large mineral attenuating mass associated with the left skull base, without intracranial involvement. A modified ventral paramedian hypophysectomy approach along the medial aspect of the left ramus was used to approach the base of the skull. Ninety percent of the mass was debulked via high-speed pneumatic burr. Histopathology was consistent with hyperostosis originating from a primary extracranial meningioma (ECM), with the tissue staining positive for vimentin and negative for cytokeratin. The patient was symptom free for 9 mo before clinical signs returned because of tumor recurrence and was euthanized 11 mo postoperation because of diminished quality of life. ECM is uncommonly reported in the dog, and to the authors’ knowledge has not previously been reported with hyperostosis or located along the skull base at the level of the tympanic bulla. Additionally, although hyperostosis predominantly occurs as diffuse bone thickening adjacent to a meningioma, proliferative focal hyperostosis is uncommon. Given the findings in this patient, ECM should be considered as a differential diagnosis for osseous skull base masses.

2016 ◽  
Vol 44 (1) ◽  
pp. 5
Author(s):  
Ítallo Barros De Freitas ◽  
Adriana Marks ◽  
Felipe Ribeiro Botelho Dos Santos ◽  
Alceu Gaspar Raiser ◽  
Alexandre Mazzanti ◽  
...  

 Background: Vascular ring anomaly is considered a hereditary change. It occurs when the fourth right aortic arch persists instead of the fourth left aortic arch, forming a vascular ring that compress the esophagus causing esophageal dilatation cranial to the compression site. Diagnosis is based upon anamnesis, physical examination, clinical signs and complementary exams (radiograph, complete blood count and biochemical tests). The clinical treatment is inadequate, since the dilatation persists and tends to progress causing irreversible tissue injury. Surgical correction is indicated and consists of the arterial ligament resection and correction of the esophageal stenosis.Case: The objective of the current study is to report two case of persistence of right aortic arch in two cats referred to the Veterinary Hospital of the Federal University of Santa Maria. On physical examination the patients were alert, in good nutritional status, adequately hydrated and presented normal colored mucous membranes. Each animal underwent radiog­raphy and esophagogram with barium sulphate. The exam demonstrated partial esophageal dilation cranial to the cardiac silhouette, suggestive of vascular ring anomaly. An exploratory thoracotomy was performed in order to achieve the definitive diagnosis. The arterial ligament was resected and esophageal stenosis corrected. Anesthesia, surgery and the postoperative period undergo without any complications. Patients remained hospitalized in the first 24 h for observation and were dis­charged after this period. Ten days surgery they returned for revaluation and removal of the skin suture. Four months after the surgical correction the animals underwent a new radiography and esophagogram examination. Radiographic findings evidenced persistence of esophageal dilation and narrowing of the esophageal lumen. Patients were evaluated periodically up to 10 months after surgery, verifying excellent quality of life and remission of clinical signs.Discussion: Vascular ring anomalies affects both dogs and cats, occurring more commonly in purebred dogs than in mixed breed. The literature reports cases in young Siamese and Persian cats, although the absolute numbers are insufficient to make conclusions about the racial predisposition. This case report enrolled two cases of PRAA in adult mixed breed cats (one male and one female from the same litter). Surgical correction is the recommended treatment for PRAA, either con­ventional or minimally invasive techniques. To assist the dissection of the fibrous ring and correction of esophageal stenosis we utilized a 22 Fr Foley catheter, introduced through the oral cavity to the esophageal stenotic area. The inflation of the balloon on the constricted area allows visualization of residual fiber rings and facilitates its dissection and removal. The PRAA mortality is associated with late diagnosis and the coexistence of aspiration pneumonia. Therefore, surgery should be performed as soon as possible after the onset of clinical signs, in order to reduce damage to the esophageal muscles and nerves. It is estimated that 80% of cases survived the postoperative period. In both cases, no clinical signs were observed, and there was a reduction of the esophageal diameter compared with the previous dilation, as well as better esophageal transit. Ten months after surgery, the animals returned for revaluation, presenting adequate body development and good quality of life. As shown in this case report, surgical intervention allowed for the accurate diagnosis and correction of PRAA in cats, with remission of clinical signs and full recovery of the animal.Keywords: cat, regurgitation, megaesophagus, thoracotomy, anomaly.


2015 ◽  
Vol 76 (S 01) ◽  
Author(s):  
Soroush Larjani ◽  
Eric Monteiro ◽  
Allan Vescan ◽  
Gelareh Zadeh ◽  
Fred Gentili ◽  
...  

2019 ◽  
Author(s):  
Danielle De Lara ◽  
Deisi Vargas ◽  
Stephanie Lindner
Keyword(s):  

Skull Base ◽  
2009 ◽  
Vol 19 (03) ◽  
Author(s):  
Harshita Pant ◽  
Carl Snyderman ◽  
Amol Bhatki ◽  
Emiro Caicedo ◽  
Ricardo Carrau ◽  
...  

Skull Base ◽  
2009 ◽  
Vol 19 (03) ◽  
Author(s):  
John de Almeida ◽  
Allan Vescan ◽  
Jolie Ringash ◽  
Patrick Gullane ◽  
Fred Gentili ◽  
...  

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
V Zlatkina ◽  
V Shkapo ◽  
A Nesen ◽  
T Starchenko

Abstract Funding Acknowledgements Type of funding sources: None. Introduction. Cardiovascular diseases (CVD) remain the leading cause of premature death worldwide. According to epidemiological studies CVD prevention is highly effective. A 50% reduction in mortality from coronary artery disease (CAD) is associated with exposure to risk factors and only 40% with improved treatment. Purpose.  To assess the quality of life (QOL) in patients with arterial hypertension (AH) and metabolic disorders, to establish its impact on therapy effectiveness. We examined 280 patients with AH and comorbidity - 171 women and 109 men aged 45-75 years. Along with AH, all patients had comorbidities: 72.6 % suffered from coronary artery disease (CAD), 10.5% after myocardial infarction (MI), 35 % had clinical signs of heart failure (HF), 22, 1% - type 2 diabetes mellitus (t2DM), 27.4% - chronic kidney disease (CKD). Methods. Anthropometry, blood pressure (BP) measurement, immunoassay (C-reactive protein), biochemical blood analysis (lipid, carbohydrate metabolism parameters, QOL determination (questionnaire Sf-36). Results. In patients with comorbidity of pathologies (presence of AH, t2DM, CKD, CAD, obesity), there was a decrease in assessments in almost all indicators of QOL, and especially significant limitations in the performance of daily activities due to both physical and mental state. Conclusion. The degree of AH in patients with t2DM decreased QOL of physical activity, role-physical functioning, pain and general health, reflecting physical health, as well as mental health, including vitality, social activity, role emotional functioning. T2DM in patients with AH significantly worsens QOL of this category of patients as in physical component summary and mental component summary. The indicators of QOL are significantly affected by the duration of t2DM, as well as the degree of compensation. Achievement of the target BP levels in patients with AH with t2DM shows an improvement in a number of QOL parameters and makes it possible to recommend the Sf-36 questionnaire as a criterion for the effectiveness of the therapy.


Dose-Response ◽  
2020 ◽  
Vol 18 (4) ◽  
pp. 155932582096391
Author(s):  
Salvatore Ferlito ◽  
Antonino Maniaci ◽  
Milena Di Luca ◽  
Calogero Grillo ◽  
Lorenzo Mannelli ◽  
...  

Purpose: The progression of the otitic infectious process toward diseases of particular severity is often unpredictable, just as it is challenging to manage the patient over time, even after the apparent resolution of the disease. We aim to define a radiological reading key that allows us to correctly and promptly treat the disease, avoiding the possible severe complications. Methods: We conducted a retrospective study of 13 cases of basal cranial osteomyelitis (SBO) due to malignant external otitis, by the ENT Department of the University of Catania. Through a standardized approach and following the latest guidelines, we have evaluated all patients performing a standardized and personalized radiological protocol according to the stage of the patient’s pathology and modulating the treatment consequently. Results: Clinical signs have been observed such as otorrhea (100%), otalgia in 13/13 patients (100%), granulations in external auditory canal (100%), preauricular cellulitis in 9/13 patients (69%) headache 6/13 cases (46%), dysphonia 4/13 cases (31%). HRCT of the temporal bone proved useful in identifying even minimal bone lesions in 13/13 (100%) while improving MRI in vascular and nervous involvement, although in 1/13 patient with nerve palsy clinical symptomatology preceded radiological evidence. The 99mTc 3-phase planar bone scintigraphy was positive for SBO in 9/13 cases (69%) during the initial phase and, in 100% of the cases in images delayed to 2-3 hours. Subsequent checks up to 1 year, using the Ga 67 scintigraphy, excluded the presence of recurrences in 100% of patients. Conclusion: The osteomyelitis of the base of the skull is a severe complication of malignant external otitis, often not always easily diagnosed. Recurrence can occur up to 1 year after stopping therapy. Imaging techniques such as Tc and MRI are relevant for the initial diagnostic approach and the staging of the pathology and its complications. Nuclear medicine imaging plays a fundamental role in the evaluation of related osteoblastic activity, especially in the remission phase of the disease.


2017 ◽  
Vol 09 (05) ◽  
pp. 1750064 ◽  
Author(s):  
A. Van Hirtum ◽  
X. Pelorson

Experiments on mechanical deformable vocal folds replicas are important in physical studies of human voice production to understand the underlying fluid–structure interaction. At current date, most experiments are performed for constant initial conditions with respect to structural as well as geometrical features. Varying those conditions requires manual intervention, which might affect reproducibility and hence the quality of experimental results. In this work, a setup is described which allows setting elastic and geometrical initial conditions in an automated way for a deformable vocal fold replica. High-speed imaging is integrated in the setup in order to decorrelate elastic and geometrical features. This way, reproducible, accurate and systematic measurements can be performed for prescribed initial conditions of glottal area, mean upstream pressure and vocal fold elasticity. Moreover, quantification of geometrical features during auto-oscillation is shown to contribute to the experimental characterization and understanding.


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