Splenic biopsy | ScienceGate

Introduction. Granulocyte colony-stimulating factor (G-CSF) is commonly used for prevention and treatment of febrile neutropenia among solid tumor patients. It is considered an effective and relatively safe supportive care medication; however, it can cause rare and serious side effects such as spleen rupture or infarction. Case Presentation. We are reporting a case of a 27-year-old female with breast cancer who has been treated with dose-dense chemotherapy and received colony-stimulating factor as primary prevention of febrile neutropenia that was complicated halfway through with splenic infarction. This finding was confirmed by computed tomography (CT) scan and splenic biopsy. Management was conservative without the need of surgical intervention. Conclusion. Although splenic infarction is an extremely rare side effect of G-CSF, it can be a serious complication that should be recognized, monitored, and managed carefully.

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Tri-axial Biopsy Needle Cauterization During Splenic Biopsy

CardioVascular and Interventional Radiology ◽

10.1007/s00270-018-1910-7 ◽

2018 ◽

Vol 41 (10) ◽

pp. 1624-1626

Author(s):

Harish A. Narayanan ◽

Venkatesh P. Krishnasamy ◽

Bradford J. Wood

Keyword(s):

Biopsy Needle ◽

Splenic Biopsy

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Evaluation of Coelioscopic Splenic Biopsy and Cloacoscopic Bursa of Fabricius Biopsy Techniques in Pigeons (Columba livia)

Journal of Avian Medicine and Surgery ◽

10.1647/1082-6742(2006)20[234:eocsba]2.0.co;2 ◽

2006 ◽

Vol 20 (4) ◽

pp. 234-241 ◽

Cited By ~ 6

Author(s):

Stephen J. Hernandez-Divers ◽

G. Heather Wilson ◽

Vanessa K. Lester ◽

Sonia M. Hernandez-Divers ◽

Kenneth S. Latimer ◽

...

Keyword(s):

Columba Livia ◽

Bursa Of Fabricius ◽

Splenic Biopsy

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Percutaneous Image-Guided Biopsy of the Spleen

Digestive Disease Interventions ◽

10.1055/s-0038-1657860 ◽

2018 ◽

Vol 02 (02) ◽

pp. 101-105

Author(s):

Alda Tam ◽

Sharjeel Sabir

Keyword(s):

Diagnostic Yield ◽

Diagnostic Approach ◽

Solid Organ ◽

Appropriate Use ◽

Image Guided ◽

Guided Biopsy ◽

Optimum Technique ◽

Splenic Biopsy

AbstractPercutaneous spleen biopsy has a small but important role in the diagnostic approach to splenic lesions. Nonetheless, there remain concerns about the safety of the procedure, limiting its use despite evidence that splenic biopsy performed with optimum technique has comparable diagnostic yield and safety as other solid organ biopsies. To assure appropriate use of percutaneous image-guided spleen biopsy, we discuss the rationale, technique, and outcomes of the procedure.

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Reticuloendothelial System: Vascular, Nonvascular, and Oncologic

Interventional Radiology ◽

10.1093/med/9780190276249.003.0047 ◽

2018 ◽

pp. 626-638

Author(s):

Ernesto Santos ◽

Joshua Pinter ◽

Kevin McCluskey

Keyword(s):

Thoracic Duct ◽

Therapeutic Option ◽

Chylous Ascites ◽

Reticuloendothelial System ◽

Arterial Aneurysm ◽

Phagocytic Cells ◽

Splenic Neoplasm ◽

Lymphatic Fistula ◽

Splenic Biopsy ◽

Clinical Conditions

The reticuloendothelial system is the portion of the immune system consisting of phagocytic cells found in reticular connective tissue in the spleen, liver, lungs, bone marrow, and lymph nodes. For the purposes of this chapter, the discussion will be limited to interventions within the spleen and the lymphatic system. Splenic arterial interventions are performed to treat a variety of clinical conditions, including abdominal trauma, hypersplenism, splenic arterial aneurysm/pseudoaneurysm, portal hypertension, and splenic neoplasm, and they provide an alternative to open surgery. Although not commonly performed, percutaneous splenic biopsy and drainage are relatively safe and efficacious procedures. Lymphangiography is a therapeutic option for patients with chylothorax, chylous ascites, and lymphatic fistula. Percutaneous thoracic duct embolization (TDE) is an alternative to surgical ligation of the thoracic duct (TD).

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Laparoscopic Splenic Biopsy—Porcine to Human Studies—Using a Fibrin Sealant Technique

Surgical Laparoscopy Endoscopy & Percutaneous Techniques ◽

10.1097/sle.0b013e318272fd01 ◽

2013 ◽

Vol 23 (2) ◽

pp. e54-e56 ◽

Cited By ~ 1

Author(s):

Kei Yiu Douglas Hui ◽

Stuart M. Robinson ◽

Aimen Amer ◽

Jonathan P. Wallis ◽

Steven A. White

Keyword(s):

Fibrin Sealant ◽

Human Studies ◽

Splenic Biopsy

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Autoantibodies in a Three-Year-Old Girl with Visceral Leishmaniasis: A Potential Diagnostic Pitfall

Case Reports in Infectious Diseases ◽

10.1155/2016/2081616 ◽

2016 ◽

Vol 2016 ◽

pp. 1-4

Author(s):

Gholamreza Pouladfar ◽

Zahra Jafarpour ◽

Amir Hossein Babaei ◽

Bahman Pourabbas ◽

Bita Geramizadeh ◽

...

Keyword(s):

Visceral Leishmaniasis ◽

Autoimmune Diseases ◽

Parasitic Infection ◽

Bone Marrow Examination ◽

Splenic Tissue ◽

Laboratory Findings ◽

Diagnostic Pitfall ◽

Antineutrophil Cytoplasmic Autoantibody ◽

Life Threatening ◽

Splenic Biopsy

Visceral leishmaniasis (VL), a life-threatening parasitic infection, is endemic in the Mediterranean region. Diagnosis of VL is based on epidemiologic, clinical, and laboratory findings. However, sometimes, clinical features and laboratory findings overlap with those of autoimmune diseases. In some cases, autoantibodies are detected in patients with VL and this could be a potential diagnostic pitfall. In this study, we have reported on a three-year-old girl from a VL-endemic area in Iran, who presented with prolonged fever and splenomegaly. Bone marrow examination, serologic tests, and the molecular PCR assay were performed; however, results were inconclusive. The levels of anti-double stranded DNA, cytoplasmic antineutrophil cytoplasmic autoantibody, and perinuclear antineutrophil cytoplasmic autoantibody were elevated and, at the end, splenic biopsy was performed. The splenic tissue PCR test detected the DNA ofLeishmania infantum. The patient’s condition improved with anti-Leishmaniatherapy, and the autoantibodies disappeared within the following four months. Clinical presentations and laboratory findings of VL and autoimmune diseases may overlap in some patients.

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Isolated Splenic Tuberculosis without Any Radiological Focal Lesion

Case Reports in Medicine ◽

10.1155/2015/130209 ◽

2015 ◽

Vol 2015 ◽

pp. 1-2 ◽

Cited By ~ 2

Author(s):

Sunil Raviraj ◽

A. Gogia ◽

A. Kakar ◽

S. P. Byotra

Keyword(s):

Histopathological Examination ◽

Bone Marrow Aspiration ◽

Clinical Findings ◽

Mantoux Test ◽

Focal Lesion ◽

Gene Probe ◽

High Grade Fever ◽

Splenic Tuberculosis ◽

Unusual Phenomenon ◽

Splenic Biopsy

Incidence of tuberculosis (TB) of spleen is a rare entity and isolated splenic tuberculosis is an unusual phenomenon, especially in immunocompetent individuals. We came across a case of 63-year-old male who presented with high grade fever, loss of weight, and generalized weakness of one-month duration. When physically examined, he had pallor and moderate nontender splenomegaly without any other significant clinical findings. He had pancytopenia, elevated ESR, and positive Mantoux test. Ultrasonography and CT scan of abdomen showed splenomegaly without any other relevant findings. Markers of connective tissue disorders and bone marrow aspiration and biopsy all were noncontributory for diagnosis. Hence splenic biopsy was done and sent for histopathological examination. Presence of caseation surrounded by epitheloid granulomas and Langerhans cells was suggestive of diagnosis as tuberculosis. And gene probe for the AFB (acid fast bacilli) came to be positive. No primary focus was present in either lungs or other organs. Patient improved clinically with antitubercular treatment.

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