Keloid scar | ScienceGate

Background: Keloid scars are benign fibrous proliferations in the dermis that arise after dermal trauma. The scars are raised in appearance and extend beyond the boundaries of the original wound. Scarring in predisposed individuals is out of proportion to the severity of the inciting wound. Current treatments sometimes yield early benefit but scars often resume exuberant growth. The pathophysiology of keloid scars is still poorly understood. In order for new treatments to be developed, the mechanisms leading to the formation of keloid scars must be further elucidated. The search for improved experimental models is of critical importance because such models have an important role to play in both the study of keloid formation and in the development of new therapies. Objective: The objective of this article is to introduce the reader to the experimental models available for studying keloid scars and to outline the advantages and limitations of animal and tissue culture models. Conclusion: Both models may help to elucidate the pathways of keloid formation and promote development and testing of therapies. Tissue culture is better suited to studies of pathogenesis, whereas the animal models are more suitable for therapeutic testing.

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Squamous cell carcinoma arising in a keloid scar

Medical Journal Armed Forces India ◽

10.1016/j.mjafi.2018.07.018 ◽

2019 ◽

Vol 75 (2) ◽

pp. 222-224 ◽

Cited By ~ 2

Author(s):

Anusree Majumder ◽

S. Srivastava ◽

P. Ranjan

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Keloid Scar

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Keloid scar as a complication of triple therapy laser treatment of a recalcitrant facial port wine stain

Clinical and Experimental Dermatology ◽

10.1111/ced.14104 ◽

2020 ◽

Vol 45 (3) ◽

pp. 385-387

Author(s):

G. Rinaldi ◽

S. Batul Syed

Keyword(s):

Triple Therapy ◽

Laser Treatment ◽

Port Wine Stain ◽

Port Wine ◽

Keloid Scar

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Multidisciplinary treatment of a massive head and neck keloid scar: A case report

SAGE Open Medical Case Reports ◽

10.1177/2050313x20936033 ◽

2020 ◽

Vol 8 ◽

pp. 2050313X2093603

Author(s):

Maninder S Longowal ◽

Barbara Humphreys RN ◽

Todd K Remington

Keyword(s):

Case Report ◽

Topical Corticosteroid ◽

Head And Neck ◽

Multidisciplinary Treatment ◽

Fractional Laser ◽

Recurrence Rates ◽

Keloid Scar ◽

Patient Morbidity ◽

Keloid Scars ◽

Ablative Fractional Laser

Keloid scars can lead to significant patient morbidity and disfigurement, especially when located on the head and neck. Massive keloid scars are particularly difficult to manage due to ulceration, infection, pain, and high recurrence rates following excision. We report the successful treatment of a massive head and neck keloid scar with excision and grafting, post-excisional radiotherapy, and ablative fractional laser-assisted topical corticosteroid delivery.

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