Electrocardiographic Changes in Type-1 Diabetes Mellitus Children with Diabetic Ketoacidosis Presenting to Tertiary care Hospital, Karachi

2021 ◽  
Vol 15 (11) ◽  
pp. 3340-3342
Author(s):  
Irum Rafique ◽  
Roshia Parveen ◽  
Zubair Khoso ◽  
Shazia Mahar ◽  
Versha Rani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Ketoacidosis ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Ecg Changes ◽  
Electrocardiographic Changes

Introduction: Cardiac arrhythmias and arrest have been described in children with diabetic ketoacidosis and generally have been presumed to be caused by electrolyte abnormalities. The rationale of this study was to assess the role and importance of ECG monitoring, as a simple, quick, non-invasive and readily available tool in the diagnosis and confirmation of hypokalemia and hyperkalemia in patients with DKA in the Emergency Department Objective: To Assess the Frequency of electrocardiographic changes in Type-1 diabetes mellitus children with diabetic ketoacidosis presenting to tertiary care hospital, Karachi. Materials and Methods: This retrospective cross sectional study was carried out at the department of pediatric medicine, NICH Karachi. At the time of presentation, the standard 12-lead ECG was recorded by a single pediatric cardiologist having more than 2 years of experience, QT and RR intervals were measured. Three separate measurements were obtained from each ECG, and the mean of these measurements was used as the value for QTC. QTC of at least 0.45s (450ms) was considered as prolonged QTC. QTD was also assessed at the same time and QTD>50 ms was considered as prolonged QTD. Results: One hundred cases of T1DM with DKA were included in this study. Average age of children was 7.9 ±3.5 years (Min – Max = 0.5 – 14 years), male to female ratio was 1: 0.96. Prolong QTc and QTd interval was observed in (56%) and (38%) children respectively, Mean (±SD) QTc and QTd interval was 449.4 ±36.6 mc and 39.3 ±16.1 mc respectively. While ECG changes were found in (58%) cases. Association between ECG changes and the cases with higher RBS (>350 mg/dl) was statistically significant 81 (81%) cases with ECG changes had higher RBS (p<0.0001) while ECG changes were statistically similar in both age groups and gender (p-values > 0.05). Conclusion: The frequency of ECG changes was higher in T1DM children with diabetic ketoacidosis. ECG changes was significantly associated with higher RBS (>350 mg/dl). Key words: T1DM, Diabetic Ketoacidosis, ECG, QTc, QTd

Clinical profile of type 1 diabetes mellitus in a tertiary care hospital

2015 ◽  
Vol 36 (2) ◽  
pp. 146-149 ◽  
Author(s):  
Ayyagari Mythili ◽  
K. Dileep Kumar ◽  
B. Vivekananda ◽  
K. A. V. Subrahmanyam
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Clinical Profile ◽  
Care Hospital

Ketoacidosis at presentation of type 1 diabetes mellitus in children: a retrospective 20-year experience from a tertiary care hospital in Serbia

2013 ◽  
Vol 172 (12) ◽  
pp. 1581-1585 ◽  
Author(s):  
Maja D. Ješić ◽  
Miloš M. Ješić ◽  
Dejana Stanisavljević ◽  
Vera Zdravković ◽  
Vladislav Bojić ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital

scholarly journals Evaluation of Children with Type 1 Diabetes Mellitus in terms of Overweight / Obesity in Tertiary Care Hospital

2021 ◽  
Author(s):  
Eda Çelebi Bitkin ◽  
Cengiz Kara ◽  
Gülay Can Yılmaz ◽  
Jamala Mammadova ◽  
Hasan Murat Aydın
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Tertiary Care ◽  
Normal Weight ◽  
Obese Group ◽  
Care Hospital ◽  
C Peptide

Abstract Objective: Obesity was once a rare problem in Type 1 diabetes mellitus, but is a growing problem today. The aim of our study is to determine the frequency of overweight / obesity at the time of diagnosis and during follow-up in children with type 1 diabetes mellitus as well as review the conditions that may accompany. Methods: 315 patients with type 1 diabetes mellitus were retrospectively analyzed. The patients were divided into two groups according to the last examination as normal weight and overweight / obese. The two groups were compared in terms of age at diagnosis, gender, birth weight, family history, anthropometric measurements, insulin dose used and blood pressure measurements, and insulin, c-peptide, hemoglobin A1c, triglyceride, and high-density lipoprotein levels at the time of diagnosis and follow-up. Results: The prevalence of overweight / obese in all patients was 4.8% at the time of diagnosis, while it was 9.8% at the last examination. The height, weight and BMI SD scores and c-peptide levels at the time of diagnosis of the overweight / obese group were higher than those with normal weight (p <0.001 and p = 0.008, respectively). The frequency of dyslipidemia and hypertension was higher in the overweight / obese group than in the normal weight group [18.2% versus 5% (p = 0.015) and 10% versus 1.5% (p = 0.003), respectively]. Conclusion: In our study, the fact that the overweight / obese group had higher BMI and c-peptide and lower HDL values at the time of diagnosis can be evaluated as indicators that insulin resistance syndrome can accompany T1DM from the beginning (double diabetes). When determining the treatment and follow-up strategies of patients with type 1 diabetes mellitus, considering the risk of obesity and taking the necessary precautions is very important in terms of morbidity.

scholarly journals Evaluation of children with type 1 diabetes mellitus in terms of overweight/obesity in tertiary care hospital

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Eda Celebi Bitkin ◽  
Cengiz Kara ◽  
Gülay Can Yılmaz ◽  
Jamala Mammadova ◽  
Hasan Murat Aydın
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Tertiary Care ◽  
Normal Weight ◽  
Obese Group ◽  
Care Hospital ◽  
C Peptide

Abstract Objectives Obesity is a growing problem in type 1 diabetes mellitus (T1DM) today. The aim of our study is to determine the frequency of overweight/obesity at the time of diagnosis and during follow-up in children with T1DM as well as review the conditions that may accompany. Methods A total of 315 patients with T1DM were retrospectively analyzed. The patients were divided into two groups as normal weight and overweight/obese. The two groups were compared in terms of age at diagnosis, birth weight, anthropometric measurements, insulin dose used and blood pressure measurements, and insulin, c-peptide, hemoglobin A1c, triglyceride, and high-density lipoprotein levels at the time of diagnosis and follow-up. Results The height, weight and body mass index standard deviation (BMI SD) scores, and c-peptide levels at the time of diagnosis of the overweight/obese group were higher than those with normal weight (p<0.001 and p = 0.008, respectively). The frequency of dyslipidemia and hypertension was higher in the overweight/obese group than in the normal weight group [18.2 vs. 5% (p = 0.015) and 10 vs. 1.5% (p = 0.003), respectively]. Conclusions In our study, the fact that the overweight/obese group had higher BMI and c-peptide and lower HDL values at the time of diagnosis can be evaluated as indicators that insulin resistance syndrome can accompany T1DM from the beginning (double diabetes). When determining the treatment and follow-up strategies of patients with T1DM, considering the risk of obesity and taking the necessary precautions is very important in terms of morbidity.

MCP-1and IL-1β expression in the myocardia of two young patients with Type 1 diabetes mellitus and fatal diabetic ketoacidosis

2014 ◽  
Vol 96 (1) ◽  
pp. 71-79 ◽  
Author(s):  
Jianli Niu ◽  
M.G.F. Gilliland ◽  
Zhuqing Jin ◽  
Pappachan E. Kolattukudy ◽  
William H. Hoffman
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Ketoacidosis ◽  
Young Patients

MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN ASSOCIATED WITH COVID-19 IN THE 6-YEAR-OLD PATIENT WITH MANIFESTATION OF TYPE 1 DIABETES MELLITUS WITH DIABETIC KETOACIDOSIS

2021 ◽  
Vol 100 (2) ◽  
pp. 295-300
Author(s):  
Yu.V. Tikhonovich ◽  
◽  
A.Yu. Rtishchev ◽  
A.A. Glazyrina ◽  
D.Yu. Ovsyannikov ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Ketoacidosis ◽  
Clinical Observation ◽  
Laboratory Data ◽  
Domestic Literature ◽  
Life Threatening ◽  
Inflammatory Syndrome

For the first time in the domestic literature, the article presents a clinical observation of multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 in the 6-year-old patient with manifestation of type 1 diabetes mellitus (T1DM) in the form of diabetic ketoacidosis. Anamnestic, clinical and laboratory data are presented on the basis of which two life-threatening diseases was diagnosed, as well as tactics of therapy, which made it possible to achieve a positive result. This clinical observation is compared with observations of foreign colleagues. Possible pathogenetic mechanisms of MIS-C and T1DM comorbidity are discussed.

Sign in / Sign up

Export Citation Format

Share Document