Inhibition of PACT mediated type 1 interferon production by herpes simplex virus type 1 Us11 protein

2014 ◽  
Author(s):  
Chun Kew
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Interferon Production ◽  
Type 1 Interferon ◽  
Simplex Virus ◽  
Us11 Protein

Phosphorylation of herpes simplex virus type 1 Us11 protein is independent of viral genome expression

1995 ◽  
Vol 16 (1) ◽  
pp. 1317-1322 ◽  
Author(s):  
Denis Simonin ◽  
Jean-Jacques Diaz ◽  
Karine Kindbeiter ◽  
Patrick Pernas ◽  
Jean-Jacques Madjar
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Viral Genome ◽  
Genome Expression ◽  
Simplex Virus ◽  
Us11 Protein

scholarly journals Inhibition of PACT-Mediated Activation of PKR by the Herpes Simplex Virus Type 1 Us11 Protein

2002 ◽  
Vol 76 (21) ◽  
pp. 11054-11064 ◽  
Author(s):  
Gregory A. Peters ◽  
David Khoo ◽  
Ian Mohr ◽  
Ganes C. Sen
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Cellular Protein ◽  
Simplex Virus ◽  
Us11 Protein

ABSTRACT PACT, a protein activator of PKR, can cause inhibition of cellular protein synthesis and apoptosis. Here, we report that the Us11 protein of herpes simplex virus type 1 can block PKR activation by PACT both in vitro and in vivo. Although Us11 can bind to both PKR and PACT, mutational analyses revealed that the binding of Us11 to PKR, and not to PACT, was essential for its inhibitory action. Similar analyses also revealed that the inhibitory effect was mediated by an interaction between the C-terminal half of Us11 and the N-terminal domain of PKR. The binding of Us11 to PKR did not block the binding of PKR to PACT but prevented its activation. Us11 is the first example of a viral protein that can inhibit the action of PACT on PKR.

scholarly journals Herpes simplex virus type 1 virion-derived US11 inhibits type 1 interferon-induced protein kinase R phosphorylation

2013 ◽  
Vol 57 (6) ◽  
pp. 426-436 ◽  
Author(s):  
Ken Ishioka ◽  
Kazufumi Ikuta ◽  
Yuka Sato ◽  
Hisatoshi Kaneko ◽  
Kotaro Sorimachi ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Protein Kinase ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Protein Kinase R ◽  
Type 1 Interferon ◽  
Simplex Virus

Role of herpes simplex virus type 1 (HSV-1) in the pathogenesis of peptic ulcer disease

2001 ◽  
Vol 120 (5) ◽  
pp. A136-A137
Author(s):  
K TSAMAKIDES ◽  
E PANOTOPOULOU ◽  
D DIMITROULOPOULOS ◽  
M CHRISTOPOULO ◽  
D XINOPOULOS ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Peptic Ulcer Disease ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Ulcer Disease ◽  
Simplex Virus
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