scholarly journals Biomarkers of Radiosensitivity in A-Bomb Survivors Pregnant at the Time of Bombings in Hiroshima and Nagasaki

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Edward F. Miles ◽  
Yoshimi Tatsukawa ◽  
Sachiyo Funamoto ◽  
Naoko Kamada ◽  
Eiji Nakashima ◽  
...  

Purpose. There is evidence in the literature of increased maternal radiosensitivity during pregnancy. Materials and Methods. We tested this hypothesis using information from the atomic-bomb survivor cohort, that is, the Adult Health Study database at the Radiation Effects Research Foundation, which contains data from a cohort of women who were pregnant at the time of the bombings of Hiroshima and Nagasaki. Previous evaluation has demonstrated long-term radiation dose-response effects. Results/Conclusions. Data on approximately 250 women were available to assess dose-response rates for serum cholesterol, white blood cell count, erythrocyte sedimentation rate, and serum hemoglobin, and on approximately 85 women for stable chromosome aberrations, glycophorin A locus mutations, and naïve CD4 T-cell counts. Although there is no statistically significant evidence of increased radiosensitivity in pregnant women, the increased slope of the linear trend line in the third trimester with respect to stable chromosome aberrations is suggestive of an increased radiosensitivity.

2008 ◽  
Vol 4 ◽  
pp. T702-T702
Author(s):  
Michiko Yamada ◽  
Fumiyoshi Kasagi ◽  
Yasuyo Mimori ◽  
Takafumi Miyachi ◽  
Tomohiko Ohshita ◽  
...  

1994 ◽  
Vol 35 (2) ◽  
pp. 155-158
Author(s):  
W. J. Russell ◽  
Y. Higashi ◽  
T. Fukuya ◽  
Y. Hosoda ◽  
J. Murakami ◽  
...  

Abdominal ultrasonographic screening for cancer was performed in 6001 Hiroshima and Nagasaki A-bomb exposed and comparison subjects, all members of the Adult Health Study of the Radiation Effects Research Foundation, formerly the Atomic Bomb Casualty Commission. This study yielded 20 cancers, including 7 hepatocellular, 3 gastric, 3 renal and 2 urinary bladder cancers; one cancer each of the ovary, pancreas, colon and ureter; and one cancer metastatic to the liver, whose primary was unknown. Seventeen of these 20 subjects manifested no symptoms or signs of their disease. A variety of additional tumors, unproven and probably benign, including uterine myomata, and other abnormalities were also detected. Abdominal ultrasonographic screening greatly assisted in the detection of cancers, most of which neither the patients nor their physicians were aware. In this screened fixed population sample the cancer detection rate was 0.33%, exceeding any such rates previously reported in the medical literature.


2009 ◽  
Vol 281 (1-2) ◽  
pp. 11-14 ◽  
Author(s):  
Michiko Yamada ◽  
Fumiyoshi Kasagi ◽  
Yasuyo Mimori ◽  
Takafumi Miyachi ◽  
Tomohiko Ohshita ◽  
...  

Gerontology ◽  
2004 ◽  
Vol 50 (2) ◽  
pp. 110-112 ◽  
Author(s):  
Michiko Yamada ◽  
Fumiyoshi Kasagi ◽  
Hideo Sasaki ◽  
Yasuyo Mimori ◽  
Gen Suzuki

Digestion ◽  
2005 ◽  
Vol 71 (4) ◽  
pp. 231-237 ◽  
Author(s):  
Michiko Yamada ◽  
F.Lennie Wong ◽  
Saeko Fujiwara ◽  
Yoshimi Tatsukawa ◽  
Gen Suzuki

2010 ◽  
Vol 6 ◽  
pp. S463-S463 ◽  
Author(s):  
Michiko Yamada ◽  
Fumiyoshi Kasagi ◽  
Yasuyo Mimori ◽  
Takafumi Miyachi ◽  
Tomohiko Ohshita ◽  
...  

2004 ◽  
Vol 25 ◽  
pp. S389-S390
Author(s):  
Michiko Yamada ◽  
Yasuyo Mimori ◽  
Fumiyoshi Kasag ◽  
Hideo Sasaki ◽  
Takafumi Miyachi ◽  
...  

2015 ◽  
Vol 351 (1-2) ◽  
pp. 115-119 ◽  
Author(s):  
Michiko Yamada ◽  
Reid D. Landes ◽  
Yasuyo Mimori ◽  
Yoshito Nagano ◽  
Hideo Sasaki

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