scholarly journals CT and SPECT image fusion using external fiducial markers for detection of the sentinel lymph nodes in breast cancer

2017 ◽  
Vol 4 (2) ◽  
pp. 23
Author(s):  
Kei Haramiishi ◽  
Shinya Nakamura ◽  
Tomoaki Tsuchiya ◽  
Atsushi Fukui ◽  
Midori Matsuyama ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Computed Tomography ◽  
Lymph Nodes ◽  
Image Fusion ◽  
Single Photon ◽  
Photon Emission ◽  
Ct Images ◽  
Fiducial Markers ◽  
Single Photon Emission ◽  
Spect Image

Object: Hybrid single-photon emission computed tomography/computed tomography, which is recently developed, is useful for the sentinel node (SN) mapping in patients with breast cancer. However, this expensive new technology is only available at limited hospitals. The purpose of this study was to assess the feasibility of software-based computed tomography (CT) and single-photon emission tomography (SPECT) image fusion using external fiducial markers for visualization of SNs in breast cancer.Methods: Preoperative lymphoscintigraphy using 99mTc-phytate colloid was performed in 70 consecutive patients (mean age, 55.3 ± 11.8). Continually, SPECT and low-dose chest CT were performed using an 241Am-containing button as an external fiducial marker attached to the skin surface of the patient’s chest wall. The acquired SPECT and CT images were rescaled, interpolated, reformatted, and registered point-by-point on a workstation.Results: SPECT detected SN sites, including axillar (n = 96) and internal mammary lesions (n = 7). On fused images, precise overlap of hot spots shown at the corresponding lymph nodes on CT images was achieved in all but 2 cases. In cases with axillar lesions, rendering the fused images into 3D volumes with accentuation of the pectoralis minor muscle was helpful for diagnosis of SN locations in level II (n = 10). After surgery, all nodes were depicted as “hot nodes” on fused images, and 14 metastatic nodes were confirmed by histological examination.Conclusions: External fiducial-based coregistration of SPECT lymphoscintigraphic and CT images depicted the precise location of SN drainage and may provide useful information for preoperative planning, without the need for hybrid SPECT/CT.

scholarly journals CT and SPECT image fusion using external fiducial markers for detection of the sentinel lymph nodes in breast cancer

2017 ◽  
Vol 4 (2) ◽  
pp. 23
Author(s):  
Kei Haramiishi ◽  
Shinya Nakamura ◽  
Tomoaki Tsuchiya ◽  
Atsushi Fukui ◽  
Midori Matsuyama ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Computed Tomography ◽  
Lymph Nodes ◽  
Image Fusion ◽  
Single Photon ◽  
Photon Emission ◽  
Ct Images ◽  
Fiducial Markers ◽  
Single Photon Emission ◽  
Spect Image

Object: Hybrid single-photon emission computed tomography/computed tomography, which is recently developed, is useful for the sentinel node (SN) mapping in patients with breast cancer. However, this expensive new technology is only available at limited hospitals. The purpose of this study was to assess the feasibility of software-based computed tomography (CT) and single-photon emission tomography (SPECT) image fusion using external fiducial markers for visualization of SNs in breast cancer.Methods: Preoperative lymphoscintigraphy using 99mTc-phytate colloid was performed in 70 consecutive patients (mean age, 55.3 ± 11.8). Continually, SPECT and low-dose chest CT were performed using an 241Am-containing button as an external fiducial marker attached to the skin surface of the patient’s chest wall. The acquired SPECT and CT images were rescaled, interpolated, reformatted, and registered point-by-point on a workstation.Results: SPECT detected SN sites, including axillar (n = 96) and internal mammary lesions (n = 7). On fused images, precise overlap of hot spots shown at the corresponding lymph nodes on CT images was achieved in all but 2 cases. In cases with axillar lesions, rendering the fused images into 3D volumes with accentuation of the pectoralis minor muscle was helpful for diagnosis of SN locations in level II (n = 10). After surgery, all nodes were depicted as “hot nodes” on fused images, and 14 metastatic nodes were confirmed by histological examination.Conclusions: External fiducial-based coregistration of SPECT lymphoscintigraphic and CT images depicted the precise location of SN drainage and may provide useful information for preoperative planning, without the need for hybrid SPECT/CT.

Utility of single-photon emission tomography/computed tomography for sentinel lymph node localization in breast cancer patients

2017 ◽  
Vol 38 (6) ◽  
pp. 493-499 ◽  
Author(s):  
Agnieszka Giżewska ◽  
Ewa Witkowska-Patena ◽  
Sebastian Osiecki ◽  
Andrzej Mazurek ◽  
Zofia Stembrowicz-Nowakowska ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Computed Tomography ◽  
Lymph Node ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Tomography ◽  
Breast Cancer Patients ◽  
Single Photon Emission ◽  
Node Localization ◽  
Photon Emission Tomography

scholarly journals Comparison of Bone Single-Photon Emission Computed Tomography (SPECT)/CT and Bone Scintigraphy in Assessing Knee Joints

2020 ◽  
Author(s):  
Young-Sil An ◽  
Do Young Park ◽  
Byoung-Hyun Min ◽  
Joon-Kee Yoon
Keyword(s):  
Computed Tomography ◽  
Single Photon ◽  
Photon Emission ◽  
Ct Images ◽  
Knee Joints ◽  
Emission Computed Tomography ◽  
Single Photon Emission ◽  
Planar Images ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography

Abstract Background: This study attempted to compare the radiopharmaceutical uptake findings of planar bone scintigraphy (BS) and single photon emission computed tomography (SPECT)/computed tomography (CT) performed on knee joints.Methods: We retrospectively included 104 patients who underwent bone SPECT/CT and BS 4 hours after the intravenous administration of technetium-99m-hydroxymethylene diphosphonate (99mTc-HDP) for pain in the knee joint. The uptake degree of each of the knee regions (medial femoral, lateral femoral, medial tibial, lateral tibial, and patellar area) in planar images and SPECT/CT were evaluated by visual (grades 0 to 2) and quantitative analyses (uptake counts for planar image and standardized uptake values [SUVs] for SPECT/CT). Results: The uptake grades assessed visually on the planar images differed significantly from the uptake grades on SPECT/CT images in all areas of the knee (all p < 0.001), and SPECT/CT imaging revealed a larger number of uptake lesions than those noted in planar imaging for each patient (3.3 ± 2.0 versus 2.4 ± 2.3, p < 0.0001). In all regions of the knee, all of the quantitative values, including uptake counts obtained from the planar image as well as the maximum SUV (SUVmax) and mean SUV (SUVmean) obtained from SPECT/CT, showed statistically higher values as their visual grades increased (all p <0.001). However, when analyzed for each area, only the SUVmax showed a significant difference by grade in all knee regions. Quantitative uptake values obtained from planar images were moderately correlated with SUVs of SPECT/CT images (r = 0.58 for SUVmean and r = 0.53 for SUVmax, all p <0.001) in the total knee regions. Looking at each area, there was a significant but low correlation between the uptake counts of the planar images and the SUVs on SPECT/CT in the right lateral tibial region (r = 0.45 for SUVmean, r = 0.31 for SUVmax, all p <0.001).Conclusions: In assessing knee joints, the findings of planar images and SPECT/CT images differ both visually and quantitatively, and more lesions can be found in SPECT/CT than in the planar images.

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