The Pancreas Morphology of Sunda Porcupine (Hystrix Javanica)

2016 ◽  
Vol 6 (2) ◽  
pp. 1211
Author(s):  
Budipitojo T ◽  
Fibrianto H ◽  
Mulyani T ◽  
Kondoh D ◽  
Sasaki N
Keyword(s):  
Pancreas Morphology

scholarly journals The gastrin-releasing peptide analog bombesin preserves exocrine and endocrine pancreas morphology and function during parenteral nutrition

2015 ◽  
Vol 309 (6) ◽  
pp. G431-G442 ◽  
Author(s):  
Joseph F. Pierre ◽  
Joshua C. Neuman ◽  
Allison L. Brill ◽  
Harpreet K. Brar ◽  
Mary F. Thompson ◽  
...  
Keyword(s):  
Endocrine Pancreas ◽  
Receptor Expression ◽  
Islet Function ◽  
Enteroendocrine Cell ◽  
Peptide Analog ◽  
Parental Nutrition ◽  
Glucagon Like Peptide 1 ◽  
And Function ◽  
Pancreas Morphology ◽  
Stimulation Of

Stimulation of digestive organs by enteric peptides is lost during total parental nutrition (PN). Here we examine the role of the enteric peptide bombesin (BBS) in stimulation of the exocrine and endocrine pancreas during PN. BBS protects against exocrine pancreas atrophy and dysfunction caused by PN. BBS also augments circulating insulin levels, suggesting an endocrine pancreas phenotype. While no significant changes in gross endocrine pancreas morphology were observed, pancreatic islets isolated from BBS-treated PN mice showed a significantly enhanced insulin secretion response to the glucagon-like peptide-1 (GLP-1) agonist exendin-4, correlating with enhanced GLP-1 receptor expression. BBS itself had no effect on islet function, as reflected in low expression of BBS receptors in islet samples. Intestinal BBS receptor expression was enhanced in PN with BBS, and circulating active GLP-1 levels were significantly enhanced in BBS-treated PN mice. We hypothesized that BBS preserved islet function indirectly, through the enteroendocrine cell-pancreas axis. We confirmed the ability of BBS to directly stimulate intestinal enteroid cells to express the GLP-1 precursor preproglucagon. In conclusion, BBS preserves the exocrine and endocrine pancreas functions during PN; however, the endocrine stimulation is likely indirect, through the enteroendocrine cell-pancreas axis.

scholarly journals Anti-Diabetic Effects of the Ethyl-Acetate Fraction of Trichilia catigua in Streptozo-tocin-Induced Type 1 Diabetic Rats

2017 ◽  
Vol 42 (3) ◽  
pp. 1087-1097 ◽  
Author(s):  
Rodrigo Mello Gomes ◽  
Luis Fernando de Paulo ◽  
Cynthia Priscilla do Nascimento Bonato Panizzon ◽  
Camila Quaglio Neves ◽  
Bruna Colombo Cordeiro ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Kidney Tissue ◽  
Ethyl Acetate Fraction ◽  
Diabetic Rats ◽  
Diabetic Group ◽  
Male Wistar Rats ◽  
Food And Water Intake ◽  
Pancreas Morphology ◽  
Group D

Background/Aims: Trichilia catigua A. Juss., known as “catuaba” in Brazil, has been popularly used as a tonic for fatigue, impotence and memory deficits. Previously, our group demonstrated that the ethyl-acetate fraction (EAF) of T. catigua has antioxidant and anti-inflammatory effects. The present study evaluated the anti-diabetic activity of EAF in type 1 diabetic rats. Methods: Male Wistar rats were divided into four groups (N: non-diabetic group, D: type 1 diabetic group, NC: non-diabetic + EAF group and DC: type 1 diabetic + EAF group). The latter two groups were treated with 200 mg/kg EAF. Type 1 diabetes was induced by intravenous streptozotocin (STZ) injection (35 mg/kg). Starting two days after STZ injection, EAF was administered daily by gavage for 8 weeks. Results: EAF attenuated body mass loss and reduced food and water intake. EAF improved hyperglycaemia and other biochemical parameters, such as alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Furthermore, the number of pancreatic β-cells and the size of the islets had increased by β-cell proliferation in the DC group. EAF promoted reduction in kidney tissue damage in STZ-induced diabetic rats by reduction of renal fibrosis. Conclusion: The present study showed that EAF improves glucose homeostasis and endocrine pancreas morphology and inhibits the development of diabetic nephropathy in STZ-induced diabetic rats.

Evidence for a significant correlation of donor pancreas morphology and the yield of isolated purified human islets

1999 ◽  
Vol 77 (1) ◽  
pp. 87-89 ◽  
Author(s):  
R. Mahler ◽  
F. E. Franke ◽  
B. J. Hering ◽  
D. Brandhorst ◽  
H. Brandhorst ◽  
...  
Keyword(s):  
Human Islets ◽  
Pancreas Morphology

scholarly journals OIL OR FLAXSEED FLOUR REDUCES PANCREATIC ISLET AREA BUT DOES NOT AFFECT SERUM INSULIN, AT WEANING, IN MALE WISTAR RATS

2018 ◽  
pp. 1-3
Author(s):  
A. D’Avila Pereira ◽  
D. Cavalcante Ribeiro ◽  
A. de Sousa dos Santos ◽  
B. Ferolla da Camara Boueri ◽  
C. Ribeiro Pessanha ◽  
...  
Keyword(s):  
Pancreatic Islet ◽  
Early Life ◽  
Wistar Rats ◽  
Serum Insulin ◽  
Serum Glucose ◽  
Flaxseed Oil ◽  
Lower Glucose ◽  
Flaxseed Flour ◽  
Male Wistar Rats ◽  
Pancreas Morphology

The aim of the present study evaluated the influence of oil or flaxseed flour in pancreas morphology of pups, whose mothers were fed with oil or flaxseed flour during lactation, at weaning. After birth, the lactating rat males were randomly assigned: control (C, n=12 pups), flaxseed oil (FO, n=12 pups) and flaxseed flour (FF, n=12). At 21 days, the pups were weaning and anesthetized. Body mass, length, serum glucose, insulin, pancreas mass and pancreatic islet area were assessed. FO and FF showed higher (p<0.05) mass and length and lower glucose (p<0.05) when compared with C. Insulin (p=0.094) and pancreas mass (p=0.054) not differ between groups. FO and FF showed lower (p<0.05) pancreatic islet area when compared with C. A fed with FO or FF, during lactation may improve function pancreatic, as insulin sensitivity. These findings emphasize that oil or flaxseed flour during lactation may improve pancreatic function in early life.

The V369M Gcgr knock-in mice are a precision medicine model of mild Mahvash disease

2020 ◽  
Vol 477 (15) ◽  
pp. 2873-2874
Author(s):  
Run Yu
Keyword(s):  
Neuroendocrine Tumor ◽  
Precision Medicine ◽  
Metabolic Profile ◽  
Pancreatic Neuroendocrine Tumor ◽  
Mutant Mice ◽  
Glucagon Receptor ◽  
Biochemical Journal ◽  
Pancreas Morphology ◽  
Inactivating Mutations

The detailed metabolic characterization of the glucagon receptor (Gcgr)V369M+/+ mutant mice described in Lin et al. in the Biochemical Journal is of interest and resulting in the expected metabolic profile. We would like to point out that these mice might also be extremely useful as a precision medicine model of mild Mahvash disease, a rare hereditary pancreatic neuroendocrine tumor syndrome characterized by inactivating mutations in the glucagon receptor. Further characterization of pancreas morphology and histology in the GcgrV369M+/+ mice at more advanced ages will be critically important to understand mild Mahvash disease in humans.

scholarly journals Tcf7l2 plays pleiotropic roles in the control of glucose homeostasis, pancreas morphology, vascularization and regeneration

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Nicola Facchinello ◽  
Estefania Tarifeño-Saldivia ◽  
Enrico Grisan ◽  
Marco Schiavone ◽  
Margherita Peron ◽  
...  
Keyword(s):  
Glucose Homeostasis ◽  
Pancreas Morphology

Effect of thyroid hormones on rat exocrine pancreas morphology and function

Life Sciences ◽  
2020 ◽  
Vol 245 ◽  
pp. 117385
Author(s):  
Francemilson Goulart-Silva ◽  
Ana Flávia Marçal Pessoa ◽  
Raquel Galvão Figueredo Costa ◽  
Paula Bargi-Souza ◽  
Marinilce Fagundes Santos ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Exocrine Pancreas ◽  
Rat Exocrine Pancreas ◽  
And Function ◽  
Pancreas Morphology

scholarly journals A Gross Morphological Study of Human Postmortem Pancreas in Bangladeshi People

1970 ◽  
Vol 8 (2) ◽  
pp. 56-58 ◽  
Author(s):  
Ahmed Firoz
Keyword(s):  
Morphological Study ◽  
Pancreatic Disease ◽  
Age Group ◽  
Same Sex ◽  
New Techniques ◽  
Group A ◽  
Group B ◽  
Pancreas Morphology ◽  
Day By Day ◽  
Age And Sex

Context: Incidence of pancreatic disease increases day by day in Bangladesh. Recent advances in pancreatic surgery and search for new techniques toward investigation of pancreas are demanding a review of the morphology of the pancreas in Bangladeshi people. Objective: To establish a gross morphological standard of pancreas in Bangladeshi people. Study design: A descriptive type of study. Place and period of study: The study was carried out in the department of Anatomy, IPGM&R, Dhaka from November 1991 to May 1992. Materials: 40 (Forty) pancreases from Bangladeshi cadaver of either sex were taken for the study. Method: The collected samples were divided according to different age and sex and comparative studies were done between different age and sex groups. Result: For both the length and weight of the pancreas, there were no significant differences between male and female in the same age group and in between group B and C in the same sex. Significant differences were found in the same sex when compared between group A & B & group C & A. Conclusion: The observation and results of the present study are expected to standardize the morphology of pancreas in Bangladeshi people. Keywords: Pancreas; morphology. DOI: 10.3329/bja.v8i2.7016Bangladesh Journal of Anatomy July 2010, Vol. 8 No. 2 pp. 56-58

Relationship between Insulin Secretion and Pancreas Morphology in Subjects with Chronic Pancreatitis

2008 ◽  
Vol 16 (S 1) ◽  
pp. 149-154 ◽  
Author(s):  
E. Zander ◽  
D. Lorenz ◽  
B. Ziegler ◽  
H. Lippert ◽  
H. Wolff ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Chronic Pancreatitis ◽  
Pancreas Morphology

Carcinoma of the Pancreas: Morphology

1994 ◽  
Vol 11 (3-6) ◽  
pp. 338-341 ◽  
Author(s):  
Arthur Zimmermann
Keyword(s):  
Carcinoma Of The Pancreas ◽  
Pancreas Morphology
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