A comparative study of effect of cold pressor test on heart rate between healthy offspring with and without parental history of Type 2 diabetes mellitus

2018 ◽  
pp. 1
Author(s):  
Arifuddin K ◽  
Vivek P
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Heart Rate ◽  
Type 2 Diabetes Mellitus ◽  
Comparative Study ◽  
Cold Pressor Test ◽  
Cold Pressor ◽  
Parental History ◽  
History Of

scholarly journals RELATIONSHIP BETWEEN PARENTAL HISTORY OF TYPE 2 DIABETES MELLITUS WITH THE SYMPATHOVAGAL BALANCE IN YOUNG ADULTS WITH COMPARABLE BMI, STRESS AND PHYSICAL ACTIVITY LEVELS

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Shakthinag S ◽  
Sandip Sardessai
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Heart Rate ◽  
Type 2 Diabetes Mellitus ◽  
Time Domain ◽  
P Value ◽  
Parental History ◽  
History Of

Background: With the heritability of Type 2 diabetes mellitus adding to the disease burden, it would be ideal to find screening tools to detect early changes that could be present in Euglycemic individuals with a genetic predisposition. Objective: To study if the parental history of type 2 diabetes mellitus has an association with the time domain, frequency domain and nonlinear basal heart rate variability indices Methods and material: Thiscross sectional study was conducted in the Physiology department of Goa Medical college over a period of 2 months on 70 Medical students between the age of 18-21 years, with low-moderate stress (PAS 10) and fair physical activity(PAI of American academy of health and fitness). Using an Inco Polyrite D instrument, data collection was done and the RR interval data was analysed using Kubios software for the basal Heart rate variability indices of time domain, frequency domain and nonlinear methods. Data was entered into Excel spreadsheet and analysed using SPSS version 14. Mann Whitney U test was done to test for statistical significance. Result: The mean age of the sample was 18.94± 0.759 years and out of the 70 subjects who had participated in the study 36 (51.4%) subjects had a positive parental family history of type 2 diabetes mellitus while 34 (48.6%) subjects did not. Significant changes were observed in the LF (nu), HF (nu) and LF/HF ratio. A significantly higher LF.n.u (p value - 0,008) and LF/HF (p value- 0.008) was observed in group with family history and a significantly lower HF.n.u ( p value – 0.007)was observed in the same group. No other significant changes were observed in time domain and non linear indices. Conclusion: Frequency domain HRV may be useful as a predictive index for diabetes mellitus. The presence of higher sympathetic activity and lower parasympathetic activity in individuals (with comparable stress level, BMI, physical activity) having a positive parental history of diabetes mellitus might indicate an underlying autonomic imbalance Keywords: Diabetes, Family history, Heart rate variability, HRV, parental history, Sympathovagal balance

scholarly journals Association of the JAZF1 Variant in Adults With a Parental History of Type 2 Diabetes Mellitus In Pakistan

Cureus ◽  
2020 ◽  
Author(s):  
Sheh Zano ◽  
Zil E Rubab ◽  
Saeeda Baig ◽  
Moazzam A Shahid ◽  
Farah Ahmad ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Parental History ◽  
History Of

scholarly journals Parental History of Type 2 Diabetes Mellitus: A Lurking Genetic Threat

2020 ◽  
pp. 66-75
Author(s):  
Sheh Zano ◽  
Zil-a- Rubab ◽  
Saeeda Baig ◽  
Burhanuddin Tahir
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Parental History ◽  
High Blood Glucose ◽  
Association Analyses ◽  
Glucose Levels ◽  
Current Prevalence ◽  
History Of

Type-2 Diabetes Mellitus (T2DM) is presently the fastest growing disease and has been recognized to be caused by a collision between inherited parental genes and the environment. The current prevalence in Pakistan of type-2 diabetes mellitus is 26.3%. Out of them 19.2% had disease two to three decades back while 7.1% are recently diagnosed cases. Worldwide burden of disease was 415 million in 2015 and this number will increase to 642 million by 2040. Parental history of diabetes mellitus is a chief reason for the development of T2DM in children, but whether this association derives from shared genetic or environmental factors is unclear. Persistent high blood glucose levels can result in drastic outcomes like Diabetic Ketoacidosis and Hyperosmolar non ketotic syndrome. Genome-wide association analyses have uncovered multiple genomic regions associated with T2DM, but identification of the causal variants remains a challenge. This review will discuss the approach of diagnosing T2DM by analyzing the association of gene variants and family history.

scholarly journals A Possible Early Alteration of Autonomic Activity Assessed by Heart Rate Variability in Saudi Offspring of Type 2 Diabetic Patients

2011 ◽  
Vol 1 (2) ◽  
pp. 17-23
Author(s):  
Daad H. Akbar ◽  
Maha A. Hegazi ◽  
Hanan A. Al Kadi ◽  
Maimona M. Ahmad
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Type 2 Diabetes Mellitus ◽  
Family History ◽  
Family History Of Diabetes ◽  
History Of

Background and Objectives: To evaluate cardiac autonomic function in non-diabetic offspring of Type 2 diabetes mellitus patients through assessment of heart rate variability. Autonomic dysfunction was reported in glucose tolerant on insulin-resistant offspring of Type 2 diabetes mellitus subjects. No data is available on cardiac autonomic dysfunction in Saudi offspring of Type 2 diabetes mellitus. Subject and Methods: Ninety-seven subjects with family history and 30 subjects with no family history of diabetes mellitus as a control group were studied. Anthropometric and biochemical characteristics (fasting blood glucose, lipids, and insulin resistance) were measured. Heart rate variability parameters were recorded. Results: No significant differences in the anthropometric, biochemical or heart rate variability parameters between the group with positive family history of diabetes mellitus and the control group. Subjects with positive family history of diabetes mellitus were split into 2 groups as per the presence or absence of insulin resistance. Insignificantly, an increased sympathetic tone was seen in Type 2 diabetes mellitus offspring with insulin resistance as compared to those without it. Body mass index, waist circumference, waist to hip ratio, total cholesterol, triglyceride, and fasting insulin and fasting blood glucose were also significantly higher in the insulin resistance group. Conclusion: There was a high prevalence of insulin resistance among the young subjects with positive family history of diabetes. Thus, had an increased sympathetic activity compared to those who were insulin sensitive. This study confirms the early autonomic dysfunction in offspring of Type 2 diabetes mellitus subjects previously reported in other non-Saudi populations.

scholarly journals A Possible Early Alteration of Autonomic Activity Assessed by Heart Rate Variability in Saudi Offspring of Type 2 Diabetic Patients

2011 ◽  
Vol 1 (2) ◽  
pp. 17-23
Author(s):  
Daad H. Akbar ◽  
Maha A. Hegazi ◽  
Hanan A. Al Kadi ◽  
Maimona M. Ahmad
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Type 2 Diabetes Mellitus ◽  
Family History ◽  
Family History Of Diabetes ◽  
History Of

Background and Objectives: To evaluate cardiac autonomic function in non-diabetic offspring of Type 2 diabetes mellitus patients through assessment of heart rate variability. Autonomic dysfunction was reported in glucose tolerant on insulin-resistant offspring of Type 2 diabetes mellitus subjects. No data is available on cardiac autonomic dysfunction in Saudi offspring of Type 2 diabetes mellitus. Subject and Methods: Ninety-seven subjects with family history and 30 subjects with no family history of diabetes mellitus as a control group were studied. Anthropometric and biochemical characteristics (fasting blood glucose, lipids, and insulin resistance) were measured. Heart rate variability parameters were recorded. Results: No significant differences in the anthropometric, biochemical or heart rate variability parameters between the group with positive family history of diabetes mellitus and the control group. Subjects with positive family history of diabetes mellitus were split into 2 groups as per the presence or absence of insulin resistance. Insignificantly, an increased sympathetic tone was seen in Type 2 diabetes mellitus offspring with insulin resistance as compared to those without it. Body mass index, waist circumference, waist to hip ratio, total cholesterol, triglyceride, and fasting insulin and fasting blood glucose were also significantly higher in the insulin resistance group. Conclusion: There was a high prevalence of insulin resistance among the young subjects with positive family history of diabetes. Thus, had an increased sympathetic activity compared to those who were insulin sensitive. This study confirms the early autonomic dysfunction in offspring of Type 2 diabetes mellitus subjects previously reported in other non-Saudi populations.

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