scholarly journals Design, Synthesis of a Novel Banana-Shaped Compounds via Esterification

2021 ◽  
Vol 17 (4) ◽  
pp. 81-92
Author(s):  
Omar Mahdi ◽  
Hanaa Salih ◽  
Abdullah Kshash
Keyword(s):  
Benzoic Acid ◽  
Absolute Ethanol ◽  
Schiff’S Bases ◽  
Melting Points ◽  
Design Synthesis ◽  
Schiff's Bases ◽  
Amino Phenol ◽  
Ft Ir ◽  
Amino Benzoic Acid

Schiff's Bases were synthesized from the reaction of p-amino benzoic acid and alkoxybenzaldehyde in absolute ethanol and reacted with (E)-3-((4-hydroxybenzylidene) amino) phenol used DCC (N,N'-Dicyclocarbodiimide) and DAMP (4-(Dimethylamino) pyridine ) to 3-(((E)-4-((4-(((E)-4 alkoxy benzylidene) amino) benzoyl) oxy) benzylidene) amino) phenyl4- (E)- 4-alkoxy benzyli dene ) amino) benzoate. The structures of the products were confirmed by their melting points, FT-IR, 1HNMR spectra.

Synthesis Characterization and Studying Antibacterial Activity of some New Pyrazol Derivatives

2021 ◽  
pp. 3905-3910
Author(s):  
Ehab Hammed Mohammed ◽  
Ezzat Hussein Zimam
Keyword(s):  
Glacial Acetic Acid ◽  
Aromatic Aldehydes ◽  
Absolute Ethanol ◽  
Basic Medium ◽  
Chloroacetyl Chloride ◽  
Pyrazole Derivatives ◽  
Melting Points ◽  
Hydrazine Derivative ◽  
Compound A ◽  
Ft Ir

This research involved the conversion of sulfadiazine into compound 2-chloro-N-(4-(N-(pyrimidin-2-yl) sulfamoyl) phenyl) acetamide [A] through the reaction of sulfadiazine with chloroacetyl chloride in the presence of diethylamine in dimethylformamide as solvent. Then prepared the hydrazine derivative of sulfadiazine 2-hydrazinyl-N-(4-(N-(pyrimidin-2-yl) sulfamoyl) phenyl) acetamide [B] through the interaction of compound [A] with hydrazine in dimethylformamide as solvent. Followed by chalcones preparation [C1, C2, C3, C4, and C5] from the reaction of 4-aminoacetophenone with some aromatic aldehydes in a basic medium in absolute ethanol using an ice bath. Pyrazoline derivatives [BC1, BC2, BC3, BC4, and BC5] were prepared from the reaction of the hydrazine derivative of sulfadiazine [B] with chalcones in a basic medium in the presence of absolute ethanol. The pyrazole derivatives [IBC1, IBC2, IBC3, IBC4, and IBC5] were prepared from the reaction of the hydrazine derivative of sulfadiazine [B] with chalcones in the presence of glacial acetic acid and then the product was oxidized using Iodine. Synthesized compounds have been studied by their melting points, and characterized by C.H.N.S analysis, FT-IR and 1H-MNR spectroscopy and studied of biological activity.

scholarly journals Synthesis and Characterization of some New 1,3,4-Oxadiazole derivatives based on 4-amino benzoic acid

2016 ◽  
Vol 13 (4) ◽  
pp. 762-769
Author(s):  
Baghdad Science Journal
Keyword(s):  
Schiff Base ◽  
Benzoic Acid ◽  
Spectral Data ◽  
1H Nmr ◽  
Synthesis And Characterization ◽  
Oxadiazole Derivatives ◽  
Ft Ir ◽  
Amino Benzoic Acid

Various of 2,5- disubstituted 1,3,4-oxadiazole (Schiff base, ?- lactam and azo) were synthesized from 2,5-di (4,4?-amino-1,3,4-oxadiazole which usequently synth-esized from mixture of 4- amino benzoic acid and hydrazine arch of polyphosphorus acid. The synthesized compounds were cherecterized by using some spectral data (UV, FT-IR , and 1H-NMR)

scholarly journals Synthesis of Heterocyclic Compounds Containing Sulphur From Ethylene Diamine Tetra Acetic acid Derivatives

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1006-1011
Author(s):  
Khudheyer Jawad Kadem
Keyword(s):  
Carbonyl Group ◽  
Heterocyclic Compounds ◽  
Thioglycolic Acid ◽  
Biological Activities ◽  
Ethylene Diamine ◽  
Mercaptoacetic Acid ◽  
Schiff’S Bases ◽  
Schiff's Bases ◽  
Ft Ir ◽  
Set Up

In this work, three novel Schiff's bases subsidiaries were set up from Ethylene Diamine Tetra Acetic corrosive Derivatives(K1, K2 and K3); (K1) which was blend from response of EDTA with 4-hydroxybenzaldehyde and 2,4-dintrophenyl hydrazine. (K2) which was union from response of EDTA with vinilline and 2,4-dintrophenyl hydrazine. (K3) which was amalgamation from response of EDTA with 4-aminoacetophenone and 2,4-dintrophenyl hydrazine after that combination three novel hetrocyclic compound Containing Sulfur molecule; Derivative with compounds containing carbonyl group (aldehyde or ketone) the carbonyl group of aldehyde or ketone react with primary amine to produce mine compounds (Schiff bases), Reaction of produced Schiff base compounds with mercaptoacetic acid (thioglycolic acid) to synthesized new heterocyclic compounds Compounds with heterogeneous ring are characterized by having many biological activities Which attracts the attention of researchers, and accordingly various derivatives containing sulfur were prepared for heterocyclic compounds, these prepared compounds can have inhibitory activity for some bacteria, fungi, and viruses. (M1,M2 and M3)which were union from response of (K1,K2 and K3) individually with marcaptoacetic acid. All of the Schiff’s bases derivatives and hetrocyclic compound Containing Sulphur atom were characterized and identified by spectroscopic methods ( FT-IR and 1H-NMR) spectroscopies.

scholarly journals Synthesis of New Substituted Tetrazole and 4-Thiazolidinone from Schiff's Bases

2020 ◽  
Vol 63 (1) ◽  
pp. 1-11
Author(s):  
Amena Alyas Ahmed ◽  
Natiq Ghanim Ahmed ◽  
Ahmad Khuder Ahmad
Keyword(s):  
Acetic Acid ◽  
13C Nmr ◽  
Nmr Spectra ◽  
Glacial Acetic Acid ◽  
Thioglycolic Acid ◽  
Absolute Ethanol ◽  
13C Nmr Spectra ◽  
Schiff’S Bases ◽  
Schiff's Bases ◽  
Tetrazole Derivatives

  The present work involved the synthesis of compound (1) (1-amino-4-methyl-6-phenyl pyrimidine- 2-(1H)-thione). This compound reacts with different aromatic aldehyde using glacial acetic acid as catalytic on absolute ethanol to give a new series of Schiff's bases (2-7). New thiazolidine-4-one were prepared from reactions of Schiff's bases (2,3,4,7) with thioglycolic acid in absolute ethanol giving compounds (8-11). Finally the preparation of new tetrazole derivatives (12-15) by reaction of Schiff's bases (2,3,4,7) with sodium azide in THF. The structure of the synthesized compounds are confirmed by I.R., 1H-NMR and 13C-NMR spectra and some physical  data.  

NOVEL SCHIFF'S BASES OF SUBSTITUTED 2-AMINO BENZOTHIAZOLES: DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITY

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (04) ◽  
pp. 18-26
Author(s):  
D. Sai Priya ◽  
◽  
S. G Kini ◽  
V. G Bhatt ◽  
E Rathi ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Docking Study ◽  
Single Step ◽  
Mass Spectrometry Data ◽  
Diffusion Method ◽  
Bacterial Strains ◽  
Schiff’S Bases ◽  
Molecular Docking Study ◽  
Design Synthesis ◽  
Schiff's Bases

Novel Schiff’s bases bearing substituted 2-amino benzothiazole were synthesized by single step process through simple condensation of 2-amino benzothiazole and substituted benzaldehydes and further characterized by FTIR, 1HNMR, and Mass spectrometry data. Antimicrobial activity of compounds was performed by agar diffusion method against a panel of bacterial strains such as S. aureus, B. subtilis (Gram-positive bacteria), E. coli, P. aeruginosa (Gram-negative bacteria) and fungal strains such as C. albicans and A. niger. Compound S13 and S17 had shown potent antifungal activity against C. albicans and A. niger respectively among the novel Schiff’s base compounds when compared to standard, and S13 compound had only shown moderate antibacterial activity against S. aureus amongst all. Molecular docking study was carried out against C. albicans DHFR (Dihydrofolate Reductase) domain to confirm their activity.

Design, Synthesis, Antioxidant and Anticancer Activity of Novel Schiff’s Bases of 2-Amino Benzothiazole

2018 ◽  
Vol 52 (4s) ◽  
pp. S333-S342 ◽  
Author(s):  
Saipriya Saipriya D ◽  
Arun Prakash ◽  
Suvarna G Kini ◽  
Varadaraj Bhatt G ◽  
K Sreedhara Ranganath Pai ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Schiff’S Bases ◽  
Design Synthesis ◽  
Schiff's Bases

scholarly journals Synthesis, Characterization of some New 1, 3, 4-Oxadiazole derivatives based on 4- amino benzoic acid

2016 ◽  
Vol 13 (2) ◽  
pp. 289-297
Author(s):  
Baghdad Science Journal
Keyword(s):  
Schiff Base ◽  
Benzoic Acid ◽  
Spectral Data ◽  
1H Nmr ◽  
Oxadiazole Derivatives ◽  
Ft Ir ◽  
Amino Benzoic Acid

In this research various of 2,5-disubstituted 1,3,4-oxadiazole (Schiff base, oxo-thiazolidine , and other compounds) were synthesized from 2,5-di(4,4?- amino-1,3,4-oxadiazole ) which use quently synthesized from mixture of 4-amino benzoic acid and hydrazine in the presence of polyphosphorus acid. The synthesized compounds were characterized by using some Spectral data (UV, FT-IR, and 1H-NMR).

scholarly journals Synthesis and Characterization of New Bidentate Schiff Base Ligand Type (NO) Donor Atoms Derived from Isatin and 3-Amino Benzoic Acid and Its Complexes with Co(II), Cu(II), Cd(II) and Hg(II) Ions

2017 ◽  
Vol 30 (3) ◽  
pp. 158
Author(s):  
Heam Hadi Alkam
Keyword(s):  
Schiff Base ◽  
Benzoic Acid ◽  
1H Nmr ◽  
Schiff Base Ligand ◽  
Chloride Content ◽  
No Donor ◽  
Imine Group ◽  
Bidentate Schiff Base Ligand ◽  
Ft Ir ◽  
Amino Benzoic Acid

New bidentate Schiff base ligand (L) namely [(Z)-3-(2-oxoindolin-3ylildeneamino)benzoic acid] type (NO) was prepared via condensation of  isatin and 3-amino benzoic acid in ethanol as a solvent in existence of drops of (glac. CH3COOH). The new ligand (L) was characterized base on elemental microanalysis, FT-IR, UV-Vis, 1H-NMR spectra along with melting point. Ligand complexes in general formula [M(L)2Cl2]. H2O, where: MII = Co, Cu, Cd, and Hg; L= C15H10 N2O3 were synthesized and identified by FT-IR, UV-Vis, 1H-NMR (for Cd complex only) spectra, atomic absorption, chloride content along with molar conductivity and magnetic susceptibility. It was found that the ligand behaves as bidentate on complexation via (N) atom of imine group and (O) atom of carbonyl group of five member ring. The electronic spectral data and µeff values (Co, Cu) of the complexes exhibited octahedral geometry around CoII, CuII, CdII, HgII metal ions. The results of antibacterial activity showed that only Hg(II) complex has high activity (35 mm) for staphylococcus aureas.

Green Synthesis, Characterization, DPPH and Ferrous Ion-chelating (FIC) Activity of Tetrakis-Schiff’s Bases of Terephthalaldehyde

2019 ◽  
Vol 16 (3) ◽  
pp. 249-255
Author(s):  
Momin Khan ◽  
Umar Ali ◽  
Anis Ur Rahman ◽  
Muhammad Ibrahim ◽  
Abdul Hameed ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Aromatic Aldehydes ◽  
Ferrous Ion ◽  
Future Research ◽  
Scavenging Activity ◽  
Schiff’S Bases ◽  
Schiff's Bases ◽  
Antioxidant Agents

Background: The role of small molecules as antioxidants to prevent the oxidation of other molecules and inhibit them from radical formation is the area of much interest to cure disease especially cancer. Moreover, the antioxidants play important role as stabilizers to prevent oxidation of fuels and lubricants. </P><P> Methods: In the present study, fifteen tetrakis-Schiff’s bases derivatives (1-15) were synthesized and screened for their antioxidant activities. Compounds 1-15 were synthesized by continuous stirring of reaction mixture of 1,4-bis (hydrazonomethyl)benzene (1 mmol) with various substituted aromatic aldehydes (2 mmol) in distilled water using acetic acid as catalyst at room temperature for 2-10 min. </P><P> Results: Our present study showed that all compounds are better ferrous ion-chelating agents except compound 1,4-bis((E)-((E)-(3,4-dimethoxybenzylidene)hydrazono)methyl)benzene (6) (IC50 = 329.26 &#177; 4.75 &#181;M) which has slightly low activity than the standard EDTA (IC50 = 318.40 &#177; 5.53 μM). In addition, DPPH radical scavenging activity of eleven compounds showed higher activity than the standard. However, remaining four compounds showed comparable radical scavenging activity to the standard DPPH (IC50 = 257.77 &#177; 4.60 &#181;M). </P><P> Conclusion: The series of fifteen Schiff’s bases (1-15) were synthesized and evaluated as antioxidants. From both assays, it has been demonstrated that most of the tetrakis-Schiff’s bases have potential to serve as leads for the development of antioxidant agents for future research.

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