Systematic Development with Quality by Design Approach of Effervescent Floating Multiple Unit Minitablets of Metoprolol Succinate using Hydrophobic Grade of Gelucire

2019 ◽  
Vol 53 (3s) ◽  
pp. s213-s224
Author(s):  
Santosh Kumar Panda ◽  
Manoranjan Sahu ◽  
Kahnu Charan Panigrahi ◽  
Chinam Niranjan Patra
Keyword(s):  
Quality By Design ◽  
Design Approach ◽  
Metoprolol Succinate ◽  
Multiple Unit ◽  
Systematic Development ◽  
Quality By Design Approach

Quality by Design approach for systematic development of nanoformulations

2021 ◽  
pp. 353-364
Author(s):  
Sarwar Beg ◽  
Mahfoozur Rahman ◽  
S.M. Kawish ◽  
Abdul Qadir ◽  
Mohamad Taleuzzaman ◽  
...  
Keyword(s):  
Quality By Design ◽  
Design Approach ◽  
Systematic Development ◽  
Quality By Design Approach

Development of novel cocrystal-based active food packaging by a Quality by Design approach

2021 ◽  
Vol 347 ◽  
pp. 129051
Author(s):  
Federica Bianchi ◽  
Fabio Fornari ◽  
Nicolò Riboni ◽  
Costanza Spadini ◽  
Clotilde Silvia Cabassi ◽  
...  
Keyword(s):  
Food Packaging ◽  
Quality By Design ◽  
Design Approach ◽  
Active Food Packaging ◽  
Quality By Design Approach

A SIMPLE AND SELECTIVE ELECTROCHEMICAL MAGNETO-ASSAY FOR SEA LICE eDNA DETECTION DEVELOPED WITH A QUALITY BY DESIGN APPROACH

2021 ◽  
pp. 148111
Author(s):  
Francesca Bettazzi ◽  
Serena Orlandini ◽  
Luna Zhang ◽  
Serena Laschi ◽  
Mari Mæland Nilsen ◽  
...  
Keyword(s):  
Quality By Design ◽  
Design Approach ◽  
Sea Lice ◽  
Quality By Design Approach

Quality by design approach in the optimization of the spray-drying process

2011 ◽  
Vol 17 (4) ◽  
pp. 389-397 ◽  
Author(s):  
Arnaud Baldinger ◽  
Lucas Clerdent ◽  
Jukka Rantanen ◽  
Mingshi Yang ◽  
Holger Grohganz
Keyword(s):  
Spray Drying ◽  
Quality By Design ◽  
Design Approach ◽  
Drying Process ◽  
Quality By Design Approach

Development of Floating Multiple Unit Minitablets of Bosentan using QbD: Characterisation and Pharmacokinetic Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Santosh Kumar Panda ◽  
Manoranjan Sahu ◽  
Kahnu Charan Panigrahi ◽  
Chinam Niranjan Patra ◽  
Goutam Kumar Jena
Keyword(s):  
Quality By Design ◽  
Critical Factor ◽  
Taguchi Design ◽  
Multiple Dosing ◽  
Release Formulation ◽  
Effect Analysis ◽  
Box Behnken Design ◽  
Multiple Unit ◽  
Quality By Design Approach ◽  
State Concentration

Background: In order to achieve steady state concentration multiple dosing is required for bosentan. Hence formulating bosentan controlled release formulation could be an approach to solve this issue. Objective: The objective is to develop floating multiple unit minitablets of bosentan using Quality by design approach. Methods: : Failure mode effect analysis (FMEA) and taguchi design employed in order to screen highly critical factor. Box-Behnken design (BBD) was adopted for the process of optimization. Results: : Amount of gelucire 39/01, HPMC K15 M and sodium bicarbonate were screened as significant factor using Taguchi design. The Box-Behnken design results the optimised formulation showing floating lag time within 3 min, floating time of nearly 15 h, time to release 50% of drug of 3.6 h and time to release 90% of drug of 11h and better bioavailability compared to pure drug. Conclusion: : It can be concluded that floating multiple unit minitablet can be used as an encouraging approach for sustaining the drug release of bosentan.

scholarly journals Functionality of Disintegrants and Their Mixtures in Enabling Fast Disintegration of Tablets by a Quality by Design Approach

2014 ◽  
Vol 15 (5) ◽  
pp. 1093-1104 ◽  
Author(s):  
Parind Mahendrakumar Desai ◽  
Patrick Xuan Hua Er ◽  
Celine Valeria Liew ◽  
Paul Wan Sia Heng
Keyword(s):  
Quality By Design ◽  
Design Approach ◽  
Quality By Design Approach
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