HMG-CoA Reductase Inhibitors Suppress the Development and Progression of Carotid Artery Intimal-medial Thickening in Hypercholesterolemic Type 2 Diabetic Patients

2005 ◽  
Vol 12 (3) ◽  
pp. 149-153 ◽  
Author(s):  
Takeshi Takahashi ◽  
Norio Ishii ◽  
Kaori Itai ◽  
Rieko Goto ◽  
Kiichiro Higashi ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Hmg Coa Reductase ◽  
Reductase Inhibitors ◽  
Hmg Coa Reductase Inhibitors ◽  
Medial Thickening ◽  
Coa Reductase ◽  
Type 2 Diabetic

Efficacy of HMG-CoA reductase inhibitors in the prevention of cerebrovascular attack in 1016 patients older than 75 years among 4014 type 2 diabetic individuals

2014 ◽  
Vol 177 (3) ◽  
pp. 860-866
Author(s):  
Toshio Hayashi ◽  
Kiyoshi Kubota ◽  
Seinosuke Kawashima ◽  
Hirohito Sone ◽  
Hiroshi Watanabe ◽  
...  
Keyword(s):  
Hmg Coa Reductase ◽  
Reductase Inhibitors ◽  
Hmg Coa Reductase Inhibitors ◽  
Coa Reductase ◽  
Type 2 Diabetic

Short telomere subtelomeric hypomethylation is associated with telomere attrition in elderly diabetic patients

2019 ◽  
Vol 97 (4) ◽  
pp. 335-339 ◽  
Author(s):  
Naoki Makino ◽  
Toyoki Maeda ◽  
Nobuyuki Abe
Keyword(s):  
Methylation Status ◽  
Statin Treatment ◽  
Diabetic Patients ◽  
Short Telomere ◽  
Telomere Shortening ◽  
Telomere Attrition ◽  
Reductase Inhibitors ◽  
Hmg Coa Reductase Inhibitors ◽  
Coa Reductase

Telomere shortening is well known to be associated with the aging process and aging-associated diseases, including diabetes. The telomere length and subtelomeric methylation status in peripheral leucocytes (LTL) were compared in elderly type 2 diabetes (T2D) patients and diabetes-free controls (C). The methylation status was analyzed between MspI-TRF lengths and HpaII-TRF lengths by using methylation-sensitive and -insensitive restriction enzyme isoschizomers, MspI and HpaII, respectively. The mean telomere lengths, MspI-TRF or HpaII-TRF, were not significantly different between C and T2D patients. The percentage of fractionated densitometry showed that long and middle telomeres (>9.4 kb, 4.4–9.4 kb) were unaltered but short telomeres (<4.4 kb) in T2D patients were increased compared with C group. The methylation status revealed subtelomeric hypomethylation in short telomeres of T2D patients. When some patients with T2D were treated with 3-hydroxy-3-methylglutaril coenzyme A (HMG-CoA) reductase inhibitors (statin), results seen in short telomere of T2D patients were not observed and were not different from C. This suggested that this altered subtelomeric hypomethylation may be associated with the accelerated telomere shortening in elderly diabetic patients. These results also mean that the subtelomeric hypomethylation can also be influenced by statin treatment in T2D.

scholarly journals Coronary Artery Disease and Carotid Artery Intima-Media Thickness in Japanese Type 2 Diabetic Patients

Diabetes Care ◽  
2002 ◽  
Vol 25 (8) ◽  
pp. 1308-1312 ◽  
Author(s):  
N. Mitsuhashi ◽  
T. Onuma ◽  
S. Kubo ◽  
N. Takayanagi ◽  
M. Honda ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Carotid Artery ◽  
Intima Media Thickness ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Media Thickness ◽  
Artery Disease ◽  
Type 2 Diabetic

Relationship of lipoprotein(a) with intimal medial thickness of the carotid artery in Type 2 diabetic patients in south India

2003 ◽  
Vol 20 (6) ◽  
pp. 455-461 ◽  
Author(s):  
K. Velmurugan ◽  
R. Deepa ◽  
R. Ravikumar ◽  
J. B. Lawrence ◽  
H. Anshoo ◽  
...  
Keyword(s):  
Carotid Artery ◽  
South India ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Lipoprotein A ◽  
Intimal Medial Thickness ◽  
Relationship Of ◽  
Type 2 Diabetic
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