Synthesis of 4-Aminocoumarin Derivatives with N-Substitutents Containing Hydroxy or Amino Groups
2013 ◽
Vol 68
(9)
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pp. 1031-1040
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Keyword(s):
X Ray
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Reactions of 4-hydroxycoumarin (1a) and 4-chlorocoumarin-3-carbaldehyde (1b) with amino alcohols or alkylene diamines led to the formation of the corresponding N-substituted 4-aminocoumarins 3, 5 and 6. However, 4-hydroxycoumarin-3-carbaldehyde (8) reacted with 2-aminoethanol and ethylenediamine to give N-substituted 3-(aminomethylene)-chromane-2,4-diones 9a, b. The structure and the E-configuration of compound 6 were proven by X-ray crystal structure analysis. Products 9a, b displayed signals of both E- and Z-isomers in their NMR spectra. All novel products have been characterized by means of spectral (IR, NMR, MS) data and elemental analyses
1999 ◽
Vol 54
(7)
◽
pp. 858-862
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Keyword(s):
Keyword(s):
1978 ◽
pp. 1536-1540
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Keyword(s):
1988 ◽
Vol 184
(3-4)
◽
pp. 209-219
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Keyword(s):