The Possible Association Of Pyoderma Gangrenosum, Kartagener's Syndrome And Rheumatoid Arthritis

Pyoderma gangrenosum is a rare inflammatory skin condition, characterized by progressive and recurrent skin ulceration. There may be rapidly enlarging, painful ulcers with undermined edges and a necrotic, hemorrhagic base. Disorders classically associated with pyoderma gangrenosum include rheumatoid arthritis, inflammatory bowel disease, paraproteinemia and myeloproliferative disorders. There have been some reports of the occurrence of pyoderma gangrenosum in Africa, and in Nigeria, but only one specifically reported pyoderma gangrenosum in association with ulcerative colitis. We report on a 45-year-old man who presented with pyoderma gangrenosum associated with ulcerative colitis; the second report in Nigeria. The skin lesions were managed with daily honey wound dressings. Oral dapsone and prednisolone were started. The frequency of the bloody diarrhea decreased, and was completely resolved by the second week after admission. The ulcers also showed accelerated healing. The goal of therapy is directed towards the associated systemic disorder, if present.

Download Full-text

Pyoderma gangrenosum and pyogenic arthritis presenting as severe sepsis in a rheumatoid arthritis patient treated with golimumab

Rheumatology International ◽

10.1007/s00296-017-3861-8 ◽

2017 ◽

Vol 38 (1) ◽

pp. 161-167 ◽

Cited By ~ 6

Author(s):

Anastasia Skalkou ◽

Sofia-Magdalini Manoli ◽

Alexandros Sachinidis ◽

Vasilios Ntouros ◽

Konstantinos Petidis ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Severe Sepsis ◽

Rheumatoid Arthritis Patient ◽

Pyoderma Gangrenosum ◽

Pyogenic Arthritis

Download Full-text

Rheumatoid Arthritis, Kartagener’s Syndrome, and Hyperprolactinemia: Who Started It?

Case Reports in Rheumatology ◽

10.1155/2016/7367232 ◽

2016 ◽

Vol 2016 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Hussein Halabi ◽

Israa Mulla

Keyword(s):

Rheumatoid Arthritis ◽

Dopamine Agonists ◽

Respiratory Infections ◽

Case Reports ◽

Experimental Treatment ◽

Chronic Stimulation ◽

Recurrent Respiratory Infections ◽

Kartagener's Syndrome ◽

History Of ◽

Stimulation Of

We report a case of an 18-year-old girl who presented to our hospital with history of recurrent respiratory infections, amenorrhea, and symmetric polyarthritis. She was diagnosed with rheumatoid arthritis (RA), Kartagener’s syndrome (KS), and hyperprolactinemia. There have been very few case reports in the literature of RA occurring in the setting of KS, theoretically proposed to be due to chronic stimulation of the immune system by recurrent infections. Furthermore, hyperprolactinemia has been hypothesized to mirror RA disease activity and case reports of treatment with dopamine agonists have led to the speculation of whether or not they represent a new line of experimental treatment in the future. Our patient was found to have both KS and hyperprolactinemia together in the setting of RA, and based on our literature search, this is the first reported case of such a combination. This strikes a very intriguing question: are these three conditions interlinked by a yet to be defined association? And treatment of which condition leads to the resolution of the other?

Download Full-text