scholarly journals Aging changes of the testis in albino rat: light, electron microscopic, morphometric, immunohistochemical and biochemical study

2020 ◽  
Vol 79 (3) ◽  
pp. 503-515
Author(s):  
S. M. Hussein ◽  
A. B. El-Fadaly ◽  
A. G. Metawea ◽  
B. E. A. Khaled
Author(s):  
O. M. Faroon ◽  
R. W. Henry ◽  
M. G. Soni ◽  
H. M. Mehendale

Previous work has shown that mirex undergoes photolytic dechlorination to chlordecone (CD) (KeponeR) in the environment. Much work has shown that prior exposure to nontoxic levels of CD causes potentiation of hepatotoxicity and lethality of CCl4, BrCCl3 and other halomethane compounds. Potentiation of bromotrichloromethane hepatotoxicity has been associated with compounds that stimulate the activity of hepatic mixed-function oxidase (MFO). An increase in the metabolism of halomethane by the MFO to a free radical initiates peroxidative decomposition of membranal lipids ending in massive cellular injury. However, not all MFO inducers potentiate BrCCl3 hepatotoxicity. Potentiation by much larger doses of phenobarbital is minimal and th at by a more potent inducer of MFO, mirex, is negligible at low doses. We suggest that the CD and bromotrichloromethane interaction results in a depletion of cellular energy and thereby reducing the cellular ability to undergo mitosis.


1985 ◽  
Vol 10 (1) ◽  
pp. 49-53 ◽  
Author(s):  
MARIE A. BADALAMENTE ◽  
L. C. HURST ◽  
J. ELLSTEIN ◽  
C. A. McDEVITT

The formation of neuroma scar after trauma or neurorrhaphy is believed to be mediated by the response of collagen forming fibroblasts. In this study of twenty human neuromas, myofibroblasts were identified as a component of the scar. These cells occurred singly or as aggregates. There was a qualitative increase of myofibroblasts during the period from two to six months post-injury. From six months to one and one-half years post-injury, numbers and aggregations of myofibroblasts diminished, concurrent with collagen proliferation. Ultrastructural alcian blue staining and biochemical analyses revealed a glucosamine—glycosaminoglycan matrix within neuromas when compared to control nerves. Myofibroblasts appear to play a part in the pathobiology of human neuromas.


2014 ◽  
Vol 196 (5) ◽  
pp. 336-351 ◽  
Author(s):  
Amina B. El-Fadaly ◽  
Ehab A.A. El-Shaarawy ◽  
Ayman A. Rizk ◽  
Mogeda M. Nasralla ◽  
Doaa M.A. Shuaib

1966 ◽  
Vol 27 (1-5) ◽  
pp. 553-567 ◽  
Author(s):  
Akira TSUTSUMI ◽  
Katsumi IWATA ◽  
Katsuo OGAWA ◽  
Kazuhiko MATSUURA

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