NLR and PLR ratios in prognostic assessment of non-small cell lung cancer patients

2016 ◽  
Vol 52 (1) ◽  
pp. 13-20
Author(s):  
Ewa Wójcik ◽  
Zofia Stasik ◽  
Urszula Rychlik ◽  
Jadwiga Tarapacz ◽  
Jan Kanty Kulpa ◽  
...  

The aim of the present study was an assessment of NLR and PLR ratios and also C-reactive protein and hemoglobin concentrations prognostic values in non-small cell lung cancer patients (NSCLC). Studied group consisted of 95 NSCLC patients with different stages of disease. The reference group consisted of 57 healthy people and 10 with non-malignant lung lesions. For every investigated individual hematological parameters and CRP concentration were measured and also NLR and PLR ratios were calculated. Compared to the reference group, NSCLC cancer patients demonstrated significantly higher leukocyte count, absolute neutrophil count, platelet count, CRP concentration and significantly lower absolute lymphocyte count and hemoglobin concentration. The values of NLR and PLR in lung cancer patients were significantly higher than in the reference group. The area under ROC curve for CRP was significantly larger than for the rest of the studied parameters apart from NLR. The area under the ROC curve for NLR was significantly larger than for PLR. There were significant positive correlations between CRP and WBC (Rs=0.2887; P=0.0046), CRP vs. NLR (Rs=0.4127; P=0.0000), CRP vs. PLR (Rs=0.4009; P=0.0006), and also reciprocal correlation with hemoglobin (CRP vs. HGB Rs=-0.4753, P=0.0000). Univariate analysis confirmed dependencies between stage of disease, performance status, age, hemoglobin and CRP concentrations, leucocyte count, absolute neutrophil count, platelet count as also NLR and PLR values and probability of 5-year survival of patients. Multivariate analysis demonstrated, that apart from stage of disease and performance status, the independent prognostic factor in NSCLC was NLR higher than 2.5.

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