scholarly journals The role of oxidative stress in female infertility and in vitro fertilization

2017 ◽  
Vol 71 (1) ◽  
pp. 0-0 ◽  
Author(s):  
Joanna Wojsiat ◽  
Jerzy Korczyński ◽  
Marta Borowiecka ◽  
Halina Małgorzata Żbikowska
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
In Vitro Fertilization ◽  
Reactive Oxygen ◽  
Reproductive Age ◽  
Oxygen Species ◽  
Female Reproduction ◽  
Vitro Fertilization ◽  
Age Related

Infertility problem involves many couples of reproductive age. It has been estimated that in Poland 0.7-1.0 million pairs require treatment, while for more than half of them assisted reproduction is the only recommended and effective method. Infertility affects 13 to 15% of the world’s population. A major concern is the age-related decline in female fertility even more that often a decision about pregnancy is taken at later age. Recent studies show that increased production of reactive oxygen species is an important factor in etiopathogenesis of pregnancy and affects female reproduction. It was found that oxidative stress may damage the oocytes and may impair their fertilization capacity. Oxidative stress may also lead to embryo fragmentation and formation of numerous developmental abnormalities, and is regarded to be one of the important reasons of spontaneous and recurrent miscarriage. Moreover, overproduction of reactive oxygen species has a significant impact on the success of in vitro fertilization (IVF).

Correlation of reactive oxygen species levels with the fertilization rate after in vitro fertilization: A qualified meta-analysis

2005 ◽  
Vol 84 (1) ◽  
pp. 228-231 ◽  
Author(s):  
Ashok Agarwal ◽  
Shyam S.R. Allamaneni ◽  
Kiran P. Nallella ◽  
Amanda T. George ◽  
Edward Mascha
Keyword(s):  
Reactive Oxygen Species ◽  
In Vitro Fertilization ◽  
Meta Analysis ◽  
Reactive Oxygen ◽  
Fertilization Rate ◽  
Oxygen Species ◽  
Vitro Fertilization

scholarly journals The essential iron-sulfur protein Rli1 is an important target accounting for inhibition of cell growth by reactive oxygen species

2012 ◽  
Vol 23 (18) ◽  
pp. 3582-3590 ◽  
Author(s):  
Alawiah Alhebshi ◽  
Theodora C. Sideri ◽  
Sara L. Holland ◽  
Simon V. Avery
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Ribosomal Subunit ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Sulfur Protein ◽  
Iron Sulfur Protein ◽  
Cellular Components

Oxidative stress mediated by reactive oxygen species (ROS) is linked to degenerative conditions in humans and damage to an array of cellular components. However, it is unclear which molecular target(s) may be the primary “Achilles’ heel” of organisms, accounting for the inhibitory action of ROS. Rli1p (ABCE1) is an essential and highly conserved protein of eukaryotes and archaea that requires notoriously ROS-labile cofactors (Fe-S clusters) for its functions in protein synthesis. In this study, we tested the hypothesis that ROS toxicity is caused by Rli1p dysfunction. In addition to being essential, Rli1p activity (in nuclear ribosomal-subunit export) was shown to be impaired by mild oxidative stress in yeast. Furthermore, prooxidant resistance was decreased by RLI1 repression and increased by RLI1 overexpression. This Rlip1 dependency was abolished during anaerobicity and accentuated in cells expressing a FeS cluster–defective Rli1p construct. The protein's FeS clusters appeared ROS labile during in vitro incubations, but less so in vivo. Instead, it was primarily55FeS-cluster supply to Rli1p that was defective in prooxidant-exposed cells. The data indicate that, owing to its essential nature but dependency on ROS-labile FeS clusters, Rli1p function is a primary target of ROS action. Such insight could help inform new approaches for combating oxidative stress–related disease.

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