Ultrasonographic evaluation of femoral cartilage thickness in patients with familial Mediterranean fever

Objectives: This study aims to determine femoral cartilage thickness using ultrasonography in familial Mediterranean fever (FMF). Patients and methods: A total of 45 patients (16 males, 29 females; mean age: 38.5±9.1 years; range, 24 to 49 years) with the diagnosis of FMF and 31 healthy individuals (6 males, 25 females; mean age: 37.0±8.7 years; range, 25 to 47 years) between January 2016 and July 2016 were included in this study. Clinical data and demographic characteristics of the patients were recorded. All FMF cases in the study were in remission with colchicine treatment. The thickness of femoral cartilage in both knees were evaluated using ultrasonography. Three measurements (mid-point) were taken from both knees (at the medial/lateral femoral condyles and intercondylar area). Results: Ultrasonographical measurements revealed that cartilage measurements of FMF patients were significantly thinner at both the medial/lateral femoral condyles and intercondylar area on the right knee and at the medial/lateral femoral condyles on the left knee (p<0.001). The cartilage measurements in FMF patients were significantly thinner at the intercondylar area on left knee, compared to those in controls (p=0.023). Conclusion: Our study showed decreased femoral cartilage thickness in FMF patients. These findings indicate that even if these patients do not have an attack, they may have subacute and chronic arthritis in their joints, and their femoral cartilage thickness can be affected.

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AB1087 THE RELATIONSHIP BETWEEN FEMORAL CARTILAGE THICKNESS AND AMYLOIDOSIS IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER: PRELIMINARY STUDY

10.1136/annrheumdis-2019-eular.6370 ◽

2019 ◽

Author(s):

Halise Hande Gezer ◽

Didem Erdem ◽

Sevtap Acer Kasman ◽

Hatice Sule Baklacioglu ◽

Mehmet Tuncay Duruöz

Keyword(s):

Familial Mediterranean Fever ◽

Cartilage Thickness ◽

Femoral Cartilage ◽

Mediterranean Fever ◽

Femoral Cartilage Thickness ◽

Preliminary Study ◽

The Relationship

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Effects of Anti-Tumor Necrosis Factor Agents for Familial Mediterranean Fever Patients With Chronic Arthritis and/or Sacroiliitis Who Were Resistant to Colchicine Treatment

JCR Journal of Clinical Rheumatology ◽

10.1097/rhu.0b013e31823682f5 ◽

2011 ◽

Vol 17 (7) ◽

pp. 358-362 ◽

Cited By ~ 49

Author(s):

Sule Apras Bilgen ◽

Levent Kilic ◽

Ali Akdogan ◽

Sedat Kiraz ◽

Umut Kalyoncu ◽

...

Keyword(s):

Tumor Necrosis Factor ◽

Familial Mediterranean Fever ◽

Tumor Necrosis ◽

Colchicine Treatment ◽

Chronic Arthritis ◽

Mediterranean Fever ◽

Necrosis Factor

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Ultrasonographic Assessment of Knee Cartilage Thickness in Patients with Ulcerative Colitis: Decreased Femoral Cartilage Thickness May Be an Indicator of Extraintestinal Manifestation in Patients with Mild Activity Ulcerative Colitis

Cartilage ◽

10.1177/1947603520968204 ◽

2020 ◽

pp. 194760352096820

Author(s):

Tolga Duzenli ◽

Emre Ata ◽

Murat Kosem

Keyword(s):

Ulcerative Colitis ◽

Cartilage Thickness ◽

Control Group ◽

Healthy Controls ◽

Knee Cartilage ◽

Extraintestinal Manifestation ◽

Femoral Cartilage ◽

Systemic Inflammatory Disease ◽

Femoral Cartilage Thickness ◽

Femoral Condyles

Objectives Ulcerative colitis is a systemic inflammatory disease which primarily involves the gut but presented by numerous extraintestinal manifestations. The effect of ulcerative colitis on knee cartilage has not been evaluated up to the present. In the current study, we aimed to investigate the possible relationship between the presence of ulcerative colitis and femoral cartilage thickness. Design Sixty-two patients with confirmed diagnosis of ulcerative colitis and 70 healthy controls aged 18 to 50 years referred to the gastroenterology outpatient department between January 2018 and January 2019 participated in this cross-sectional study. The measurements were made by ultrasonography with the patient in a supine position and the knees in complete flexion. Demographic, clinical, endoscopic and laboratory data were collected for all the subjects. Results The groups of ulcerative colitis and control group were similar with regard to sex, mean age, weight, height, body mass index, extremity dominancy, and existence of knee pain ( P > 0.05). Medial femoral condyles, intercondylar areas, and lateral femoral condyles of both right and left knees had thinner cartilage thickness in ulcerative colitis group than control group ( P < 0.001). Conclusion Knee cartilage was thinner in subjects with mild activity ulcerative colitis than in healthy controls. Decreased knee cartilage thickness may be an indicator of extraintestinal manifestation in patients with mild activity ulcerative colitis. This association between ulcerative colitis and knee cartilage degeneration may be effective in early detection of possible risk factors and potential treatment strategies for both ulcerative colitis and specific subtypes of knee osteoarthritis.

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Increased Femoral Cartilage Thickness in Patients With Klinefelter Syndrome

American Journal of Men s Health ◽

10.1177/1557988312458449 ◽

2012 ◽

Vol 7 (1) ◽

pp. 54-57 ◽

Cited By ~ 2

Author(s):

Mehmet Inci ◽

Ozgur Akgul ◽

Numan Baydilli ◽

Oguz Ekmekcioglu ◽

Salih Özgöçmen

Keyword(s):

Klinefelter Syndrome ◽

Tertiary Care ◽

Left Knee ◽

Cartilage Thickness ◽

Sex Hormone Binding Globulin ◽

Controlled Study ◽

Estrogen Metabolism ◽

Total Testosterone ◽

Femoral Cartilage ◽

Femoral Cartilage Thickness

The objective of this study was to determine femoral cartilage thickness (FCT) in patients with Klinefelter syndrome (KS), which is the most common sex chromosome disorder in men with varying degrees of androgen deficiency. This cross-sectional controlled study was conducted in a tertiary care center. Participants were 33 male patients (mean age = 36.2 years) with KS and 35 aged-matched healthy male controls (mean age = 32.9 years). Femoral condyle cartilage was measured by ultrasonography at three locations in each knee. Total testosterone, estradiol, sex hormone binding globulin, free androgen index, bioavailable testosterone, and albumin levels were measured. Femoral cartilage of patients at right and left knee lateral (3.03 and 2.99 mm), mid (3.81 and 3.74 mm), and medial (3.01 and 3.20 mm) were statistically thicker than in controls (right and left knee lateral 2.29 and 2.36 mm, mid 2.64 and 2.53 mm, medial 2.39 and 2.32 mm, respectively, p < .001). There was no significant correlation between FCT and sex hormones. In conclusion, patients with KS had thicker femoral cartilage. Relatively low testosterone levels in these patients and altered estrogen metabolism may hypothetically explain increased cartilage thickness in these patients.

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