The Effects of Acid Regurgitation and Dyspepsia on Sleep Quality and Work Productivity of Patients with Laryngopharyngeal Reflux Disease (LPRD)

Background:To explore whether combined with TCM based on classical proton pumpinhibitors PPIs therapy can achieve better efficacy for patients withlaryngopharyngeal reflux disease. Methods: There were 150 laryngopharyngeal refluxpatients enrolled and divided into three groups randomly, with 50 cases in each group.Patients in group A were treated with the proton pump inhibitor (PPI) lansoprazole.Patients in group B were treated with lansoprazole combined with Banxia Houpudecoction, and patients in group C were treated with acupuncture treatments and acombination of Chinese and Western medicine. The reflux symptom index (RSI), refluxfinding score (RFS), and quality of life (36 item short form health survey questionnaire)were assessed before and 4 and 8 weeks after treatment. Results: The RSI and RFSscores of the three groups were significantly reduced after treatment (P < 0.001). Ingroup B and C, they were lower than in group A at 8 weeks (P < 0.01). The SF 36 scoreof 3 groups increased after treatment. At both 4 and 8 weeks (P < 0.001), and patientsin groups B and C scored higher than patients in group A (P < 0.001). The total effectiverate of group B and group C was higher than that of group A (P < 0.05). Conclusion:All three treatments have therapeutic effects on the disease, but the efficacy of a PPIalone is not as good as the combined treatments’ efficacies. Moreover, PPI combinedwith Banxia Houpu decoction and/or acupuncture treatment substantially affects lifeimprovement.

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Usefulness of Matrix Metalloproteinase-7 in Saliva as a Diagnostic Biomarker for Laryngopharyngeal Reflux Disease.

10.21203/rs.3.rs-490220/v1 ◽

2021 ◽

Author(s):

Nu-Ri Im ◽

Byoungjae Kim ◽

Kwang-Yoon Jung ◽

Seung-Kuk Baek

Keyword(s):

Matrix Metalloproteinase ◽

Sensitivity And Specificity ◽

Reflux Disease ◽

Laryngopharyngeal Reflux ◽

Diagnostic Methods ◽

Reflux Symptom Index ◽

Enzyme Activity Assay ◽

Symptom Index ◽

Laryngopharyngeal Reflux Disease ◽

Matrix Metalloproteinase 7

Abstract Introduction Several diagnostic methods are currently being used to diagnose LPRD (laryngopharyngeal reflux disease), but have the disadvantage of being invasive, subjective, or expensive. Objectives Our purpose in this study was to investigate the correlation between pepsin and MMP-7 (Matrix Metalloproteinase-7) in pharyngeal secretions of subjects according to RSI (Reflux Symptom Index) score to find out the diagnostic value of MMP-7. Method We recruited 173 subjects aged between 19 and 85 years who completed the RSI scale. All samples were taken after waking up, and the amount of the pepsin and MMP-7 in saliva were measured by means of an enzyme activity assay. Results There was a significant increase of pepsin and MMP-7 activity in the study group with an RSI score of 13 or higher. The sensitivity and specificity of MMP-7 for predicting the possibility of an RSI of 13 or more was higher than that of pepsin. When MMP-7 and pepsin were combined, this sensitivity and specificity increased. Conclusion An enzyme assay of MMP-7 in saliva may be a noninvasive and easy technique for diagnosing LPRD.

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Laryngopharyngeal Reflux Disease - LPRD

Medical Archives ◽

10.5455/medarh.2017.71.215-218 ◽

2017 ◽

Vol 71 (3) ◽

pp. 215 ◽

Cited By ~ 13

Author(s):

Nizama Salihefendic ◽

Muharem Zildzic ◽

Emir Cabric

Keyword(s):

Reflux Disease ◽

Laryngopharyngeal Reflux ◽

Laryngopharyngeal Reflux Disease

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SPECIFICS AND DIAGNOSTIC PROCEDURE IN REFLUX-RELATED DYSPHONIA

Wiadomości Lekarskie ◽

10.36740/wlek202004137 ◽

2020 ◽

Vol 73 (4) ◽

pp. 814-817

Author(s):

Klaudia Sowa ◽

Anna Łobaczuk-Sitnik ◽

Bartosz Piszczatowski ◽

Emilia Duchnowska ◽

Bożena Kosztyła-Hojna ◽

...

Keyword(s):

Chronic Diseases ◽

Reflux Disease ◽

Laryngopharyngeal Reflux ◽

Morphological Changes ◽

Voice Disorders ◽

Vocal Folds ◽

Congenital Defects ◽

Upper Respiratory Tract ◽

Laryngopharyngeal Reflux Disease ◽

Pharynx Cancer

Voice is a work tool for many professional groups. Currently, cases of dysphonia of multiple origin consist a growing issue. Voice disorders may result from disturbed voice production process, congenital defects, post-traumatic conditions, chronic diseases or hormonal disorders. Chronic diseases causing voice disorders include laryngopharyngeal reflux disease and esophageal reflux disease. The chronic character of reflux causes the formation of numerous morphological changes of the larynx, including: hyperemia of the mucosa limited to arytenoid and intraarytenoid area, edema of the vocal folds, edema of the larynx mucosa. These changes contribute to voice disorders. Among the pathological changes of voice organ etiologically associated with reflux, the following disease units may be distinguished: reflux laryngitis, subglottic edema, contact ulceration, larynx granuloma, larynx and pharynx cancer. Many of disorders in the upper respiratory tract are etiologically related to reflux, e.g. dysphonia, grunting, coughing and dyspnoea.

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