scholarly journals Sleep Disordered Breathing and White Matter Hyperintensities in Community-Dwelling Elders

SLEEP ◽  
2016 ◽  
Vol 39 (4) ◽  
pp. 785-791 ◽  
Author(s):  
Sara K. Rostanski ◽  
Molly E. Zimmerman ◽  
Nicole Schupf ◽  
Jennifer J. Manly ◽  
Andrew J. Westwood ◽  
...  
Keyword(s):  
White Matter ◽  
Sleep Disordered Breathing ◽  
White Matter Hyperintensities ◽  
Community Dwelling ◽  
Disordered Breathing

scholarly journals The association of sleep-disordered breathing and white matter hyperintensities in heart failure patients

2018 ◽  
Vol 33 (6) ◽  
pp. 2019-2029
Author(s):  
Chooza Moon ◽  
Barbara B. Bendlin ◽  
Kelsey E. Melah ◽  
Lisa C. Bratzke
Keyword(s):  
Heart Failure ◽  
White Matter ◽  
Sleep Disordered Breathing ◽  
White Matter Hyperintensities ◽  
Heart Failure Patients ◽  
Disordered Breathing

Abstract P366: High Burden of Tract-Specific White Matter Hyperintensities Relates to Impaired Microstructural Integrity of Distal White Matter Tracts in Community-Dwelling Elders

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
YANPENG LIU ◽  
YIWEI XIA ◽  
XIAOXIAO WANG ◽  
YI WANG ◽  
LUMENG YANG ◽  
...  
Keyword(s):  
Executive Function ◽  
White Matter ◽  
Cognitive Dysfunction ◽  
White Matter Hyperintensities ◽  
Brain Mri ◽  
Mean Diffusivity ◽  
Community Dwelling ◽  
Superior Longitudinal Fasciculus ◽  
High Burden ◽  
Microstructural Integrity

Background and purpose: White matter hyperintensities (WMH) are common in elderly individuals and contribute to age-related cognitive dysfunction. Converging evidence indicates that WMH affect white matter (WM) microstructural integrity in WMH and their penumbra. We aimed to investigate whether this effect extends to the distal WM tracts, and to examine the association between distal WM microstructural integrity and cognitive dysfunction in community-dwelling elderly people. Methods: Brain MRI data including FLAIR and DTI sequences of 174 participants (74 ± 5 years) of the Shanghai Aging Study (SAS) were collected and analyzed. For each participant, WMH lesions were segmented automatically. Eighteen major WM tracts were reconstructed using automated quantitative tractography, and the mean diffusivity (MD) of distal WM tracts (excluding an area of 12 mm around the WMH) was calculated. Multivariable linear regression was performed. Results: A high burden of tract-specific WMH was related to a high MD of distal WM tracts in the forceps major (FMA), anterior thalamic radiations (ATR), cingulum cingulate gyrus (CCG), corticospinal tract (CST), superior longitudinal fasciculus-parietal (SLFP), superior longitudinal fasciculus-temporal (SLFT), and uncinate fasciculus (UNC). Furthermore, a high MD of distal tracts was linked to worse attention and executive function in the forceps minor (FMI), right CCG, left inferior longitudinal fasciculus (ILF), SLFP, SLFT and UNC. Conclusions: The effect of WMH on the microstructural integrity of WM tracts may propagate along tracts to distal regions farther than the penumbra and eventually might affect attention and executive function.

scholarly journals Sleep-Disordered Breathing and White Matter Disease in the Brainstem in Older Adults

SLEEP ◽  
2004 ◽  
Vol 27 (3) ◽  
pp. 474-479 ◽  
Author(s):  
Jingzhong Ding ◽  
F. Javier Nieto ◽  
Norman J. Beauchamp ◽  
Tamara B. Harris ◽  
John A. Robbins ◽  
...  
Keyword(s):  
Older Adults ◽  
White Matter ◽  
Sleep Disordered Breathing ◽  
White Matter Disease ◽  
Disordered Breathing

White matter disease and sleep-disordered breathing after acute stroke

Neurology ◽  
2003 ◽  
Vol 61 (7) ◽  
pp. 959-963 ◽  
Author(s):  
J. Harbison ◽  
G. J. Gibson ◽  
D. Birchall ◽  
I. Zammit-Maempel ◽  
G. A. Ford
Keyword(s):  
White Matter ◽  
Acute Stroke ◽  
Sleep Disordered Breathing ◽  
White Matter Disease ◽  
Disordered Breathing

Correlates of memory function in community-dwelling elderly: The importance of white matter hyperintensities

2004 ◽  
Vol 10 (03) ◽  
Author(s):  
CHRISTOPHER I. PETKOV ◽  
CHRISTINE C. WU ◽  
JAMIE L. EBERLING ◽  
DAN MUNGAS ◽  
PATRICIA A. ZRELAK ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Memory Function ◽  
Community Dwelling

Prospective associations between white matter hyperintensities and lower extremity function

Neurology ◽  
2018 ◽  
Vol 90 (15) ◽  
pp. e1291-e1297 ◽  
Author(s):  
So Young Moon ◽  
Philipe de Souto Barreto ◽  
Yves Rolland ◽  
Marie Chupin ◽  
Ali Bouyahia ◽  
...  
Keyword(s):  
Older Adults ◽  
White Matter ◽  
Lower Extremity ◽  
White Matter Hyperintensities ◽  
Brain Mri ◽  
Community Dwelling ◽  
Lower Extremity Function ◽  
Mixed Effect ◽  
Extremity Function ◽  
Slow Progression

ObjectiveTo evaluate the relationship of white matter hyperintensities (WMH) with decline in lower extremity function (LEF) over approximately 3 years in dementia-free older adults with memory complaints.MethodsWe obtained brain MRI data from 458 community-dwelling adults, aged 70 years or over, at baseline, and from 358 adults over an average follow-up of 963 days. We evaluated LEF using the Short Physical Performance Battery (SPPB). We related baseline WMH volumes and progression to SPPB scores over time, using mixed-effect linear regressions. For the secondary analyses, we categorized baseline WMH volume into quartiles, and dichotomized the WMH progression to compare fast and slow progression.ResultsBaseline WMH volume (β = −0.017, 95% confidence interval [CI] −0.025 to −0.009), as well as WMH progression (β = −0.002, 95% CI −0.003 to −0.001), significantly associated with a decline in SPPB performance in adjusted analyses. Compared with the lowest quartile of baseline WMH volume, the highest quartile associated with a decline in SPPB performance (β = −0.301, 95% CI −0.558 to −0.044). Fast progression also associated with a decline in SPPB performance. We found clinically meaningful differences in the SPPB, with higher scores in participants with slow progression of WMH, at both 24 and 36 months.ConclusionsBaseline level and WMH progression associated with longitudinal decline in SPPB performance among older adults. We detected clinically meaningful differences in SPPB performance on comparing fast with slow progression of WMH, suggesting that speed of WMH progression is an important determinant of LEF during aging.

scholarly journals White matter hyperintensities classified according to intensity and spatial location reveal specific associations with cognitive performance

2020 ◽  
Author(s):  
Luca Melazzini ◽  
Clare E Mackay ◽  
Valentina Bordin ◽  
Sana Suri ◽  
Eniko Zsoldos ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Linear Models ◽  
Small Vessel Disease ◽  
Spatial Location ◽  
Community Dwelling ◽  
New Approach ◽  
Radiological Criteria ◽  
Intensity Information ◽  
Community Dwelling Older Adults

White matter hyperintensities (WMHs) on T2-weighted images are radiological signs of cerebral small vessel disease. As their total volume is variably associated with cognition, a new approach that integrates multiple radiological criteria is warranted. Location may matter, as periventricular WMHs have been shown to be associated with cognitive impairments. WMHs that appear as hypointense in T1-weighted images (T1w) may also indicate the most severe component of WMHs. We developed an automatic method that classifies WMHs into four categories (periventricular/deep and T1w-hypointense/nonT1w-hypointense) using MRI data from 684 community-dwelling older adults from the Whitehall II study. To test if location and intensity information can impact cognition, we derived two general linear models using either overall or subdivided volumes. Results showed that periventricular T1w-hypointense WMHs were significantly associated with poorer performance in several cognitive tests. We found no association between total WMH volume and cognition. These findings suggest that classifying WMHs according to both location and intensity in T1w adds value over and above total WMH volume.

Sign in / Sign up

Export Citation Format

Share Document