scholarly journals White matter hyperintensities classified according to intensity and spatial location reveal specific associations with cognitive performance

2020 ◽  
Author(s):  
Luca Melazzini ◽  
Clare E Mackay ◽  
Valentina Bordin ◽  
Sana Suri ◽  
Eniko Zsoldos ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Linear Models ◽  
Small Vessel Disease ◽  
Spatial Location ◽  
Community Dwelling ◽  
New Approach ◽  
Radiological Criteria ◽  
Intensity Information ◽  
Community Dwelling Older Adults

White matter hyperintensities (WMHs) on T2-weighted images are radiological signs of cerebral small vessel disease. As their total volume is variably associated with cognition, a new approach that integrates multiple radiological criteria is warranted. Location may matter, as periventricular WMHs have been shown to be associated with cognitive impairments. WMHs that appear as hypointense in T1-weighted images (T1w) may also indicate the most severe component of WMHs. We developed an automatic method that classifies WMHs into four categories (periventricular/deep and T1w-hypointense/nonT1w-hypointense) using MRI data from 684 community-dwelling older adults from the Whitehall II study. To test if location and intensity information can impact cognition, we derived two general linear models using either overall or subdivided volumes. Results showed that periventricular T1w-hypointense WMHs were significantly associated with poorer performance in several cognitive tests. We found no association between total WMH volume and cognition. These findings suggest that classifying WMHs according to both location and intensity in T1w adds value over and above total WMH volume.

scholarly journals Localization of Brain White Matter Hyperintensities and Urinary Incontinence in Community-Dwelling Older Adults

2009 ◽  
Vol 64A (8) ◽  
pp. 902-909 ◽  
Author(s):  
G. A. Kuchel ◽  
N. Moscufo ◽  
C. R. Guttmann ◽  
N. Zeevi ◽  
D. Wakefield ◽  
...  
Keyword(s):  
Older Adults ◽  
Urinary Incontinence ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Community Dwelling ◽  
Brain White Matter ◽  
Community Dwelling Older Adults

Dawson Fingers in Older Adults with Cerebral Small Vessel Disease: A Population Study

2020 ◽  
Vol 83 (4) ◽  
pp. 421-425
Author(s):  
Oscar H. Del Brutto ◽  
Robertino M. Mera ◽  
Aldo F. Costa ◽  
Patricia Silva ◽  
Victor J. Del Brutto
Keyword(s):  
Older Adults ◽  
White Matter ◽  
Small Vessel Disease ◽  
Brain Mri ◽  
Subcortical White Matter ◽  
Cerebral Small Vessel Disease ◽  
Community Dwelling ◽  
Small Vessel ◽  
Vessel Disease ◽  
Community Dwelling Older Adults

Dawson fingers are used to differentiate multiple sclerosis (MS) from other conditions that affect the subcortical white matter. However, there are no studies evaluating the presence of Dawson fingers in subjects with cerebral small vessel disease (cSVD). We aimed to assess prevalence and ­correlates of Dawson fingers in older adults with cSVD-related moderate-to-severe white matter hyperintensities (WMH). Community-dwelling older adults residing in rural Ecuador – identified by means of door-to-door surveys – underwent a brain MRI. Exams of individuals with cSVD-related moderate-to-severe WMH were reviewed with attention to the presence of Dawson fingers. Of 590 enrolled individuals, 172 (29%) had moderate-to-severe WMH. Of these, 18 (10.5%) had Dawson fingers. None had neurological manifestations suggestive of MS. Increasing age was independently associated with Dawson fingers (p = 0.017). Dawson fingers may be less specific for MS than previously thought. Concomitant damage of deep medullary veins may explain the presence of Dawson fingers in cSVD.

scholarly journals White matter correlates of scam susceptibility in community-dwelling older adults

2019 ◽  
Vol 14 (5) ◽  
pp. 1521-1530 ◽  
Author(s):  
Melissa Lamar ◽  
Konstantinos Arfanakis ◽  
Lei Yu ◽  
Shengwei Zhang ◽  
S. Duke Han ◽  
...  
Keyword(s):  
Older Adults ◽  
White Matter ◽  
Community Dwelling ◽  
Community Dwelling Older Adults

scholarly journals Sleep Disordered Breathing and White Matter Hyperintensities in Community-Dwelling Elders

SLEEP ◽  
2016 ◽  
Vol 39 (4) ◽  
pp. 785-791 ◽  
Author(s):  
Sara K. Rostanski ◽  
Molly E. Zimmerman ◽  
Nicole Schupf ◽  
Jennifer J. Manly ◽  
Andrew J. Westwood ◽  
...  
Keyword(s):  
White Matter ◽  
Sleep Disordered Breathing ◽  
White Matter Hyperintensities ◽  
Community Dwelling ◽  
Disordered Breathing

Influence of White Matter Hyperintensities on Baseline and Longitudinal Amyloid-β in Cognitively Normal Individuals

2021 ◽  
pp. 1-11
Author(s):  
Fennie Choy Chin Wong ◽  
Seyed Ehsan Saffari ◽  
Chathuri Yatawara ◽  
Kok Pin Ng ◽  
Nagaendran Kandiah ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Executive Function ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Small Vessel Disease ◽  
Amyloid Β ◽  
Intracranial Volume ◽  
Linear Regression Models ◽  
Cognitively Normal

Background: The associations between small vessel disease (SVD) and cerebrospinal amyloid-β1-42 (Aβ1-42) pathology have not been well-elucidated. Objective: Baseline (BL) white matter hyperintensities (WMH) were examined for associations with month-24 (M24) and longitudinal Aβ1-42 change in cognitively normal (CN) subjects. The interaction of WMH and Aβ1-42 on memory and executive function were also examined. Methods: This study included 72 subjects from the Alzheimer’s Disease Neuroimaging Initiative. Multivariable linear regression models evaluated associations between baseline WMH/intracranial volume ratio, M24 and change in Aβ1-42 over two years. Linear mixed effects models evaluated interactions between BL WMH/ICV and Aβ1-42 on memory and executive function. Results: Mean age of the subjects (Nmales = 36) = 73.80 years, SD = 6.73; mean education years = 17.1, SD = 2.4. BL WMH was significantly associated with M24 Aβ1-42 (p = 0.008) and two-year change in Aβ1-42 (p = 0.006). Interaction between higher WMH and lower Aβ1-42 at baseline was significantly associated with worse memory at baseline and M24 (p = 0.003). Conclusion: BL WMH was associated with M24 and longitudinal Aβ1-42 change in CN. The interaction between higher WMH and lower Aβ1-42 was associated with poorer memory. Since SVD is associated with longitudinal Aβ1-42 pathology, and the interaction of both factors is linked to poorer cognitive outcomes, the mitigation of SVD may be correlated with reduced amyloid pathology and milder cognitive deterioration in Alzheimer’s disease.

Altered Functional Connectivity Patterns of Parietal Subregions Contribute to Cognitive Dysfunction in Patients with White Matter Hyperintensities

2021 ◽  
pp. 1-11
Author(s):  
Qiang Wei ◽  
Shanshan Cao ◽  
Yang Ji ◽  
Jun Zhang ◽  
Chen Chen ◽  
...  
Keyword(s):  
White Matter ◽  
Functional Connectivity ◽  
White Matter Hyperintensities ◽  
Parietal Lobe ◽  
Small Vessel Disease ◽  
Anterior Cingulate ◽  
Healthy Controls ◽  
Cingulate Gyrus ◽  
Anterior Cingulate Gyrus ◽  
Resting State Functional Connectivity

Background: The white matter hyperintensities (WMHs) are considered as one of the core neuroimaging findings of cerebral small vessel disease and independently associated with cognitive deficit. The parietal lobe is a heterogeneous area containing many subregions and play an important role in the processes of neurocognition. Objective: To explore the relationship between parietal subregions alterations and cognitive impairments in WHMs. Methods: Resting-state functional connectivity (rs-FC) analyses of parietal subregions were performed in 104 right-handed WMHs patients divided into mild (n = 39), moderate (n = 37), and severe WMHs (n = 28) groups according to the Fazekas scale and 36 healthy controls. Parietal subregions were defined using tractographic Human Brainnetome Atlas and included five subregions for superior parietal lobe, six subregions for inferior parietal lobe (IPL), and three subregions for precuneus. All participants underwent a neuropsychological test battery to evaluate emotional and general cognitive functions. Results: Differences existed between the rs-FC strength of IPL_R_6_2 with the left anterior cingulate gyrus, IPL_R_6_3 with the right dorsolateral superior frontal gyrus, and the IPL_R_6_5 with the left anterior cingulate gyrus. The connectivity strength between IPL_R_6_3 and the left anterior cingulate gyrus were correlated with AVLT-immediate and AVLT-recognition test in WMHs. Conclusion: We explored the roles of parietal subregions in WMHs using rs-FC. The functional connectivity of parietal subregions with the cortex regions showed significant differences between the patients with WMHs and healthy controls which may be associated with cognitive deficits in WMHs.

scholarly journals Cognitive heterogeneity among community-dwelling older adults with Cerebral Small Vessel Disease

2018 ◽  
Author(s):  
Ayan Dey ◽  
Vessela Stamenova ◽  
Agnes Bacopulos ◽  
Nivethika Jeyakumar ◽  
Gary R. Turner ◽  
...  
Keyword(s):  
White Matter ◽  
Subjective Experience ◽  
Small Vessel Disease ◽  
Neuropsychological Testing ◽  
Cerebral Small Vessel Disease ◽  
Community Dwelling ◽  
Small Vessel ◽  
Vessel Disease ◽  
Age Related ◽  
Subjective Complaints

Some degree of ischemic injury to white matter tracts occurs naturally with age and is visible on magnetic resonance imaging as focal or confluent white matter hyperintensities (WMHs). Its relationship to cognition, however, remains unclear. To explore this, community-dwelling adults between the ages 55-80 years old completed structural imaging, neuropsychological testing, and questionnaires to provide objective measures and subjective experience of executive functioning. Volumetric lesion burden derived from structural MRI identified those with significant WMH burden (~10 cubic cm). Half of those recruited met this criterion and were designated as the cerebral small vessel disease (CSVD) group. Subjective complaints but not objective test scores differentiated adults with and without CSVD. Hierarchical clustering revealed two CSVD subgroups that differentiated those with impaired versus preserved executive function relative to controls. Overall these results provide some explanation for behavioural heterogeneity often observed in studies of age-related white matter changes. They also support the use of questionnaires to assess subjective complaints that may be able to detect subtle effects of pathology not evident on standardized cognitive scores.

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