Neonatal thyroid‐stimulating hormone concentrations in northern Sydney: further indications of mild iodine deficiency?

Background: Iodine deficiency is associated with goiter and impaired brain function. Neonatal thyroid-stimulating hormone (TSH) screening for congenital hypothyroidism used as an indicator of the degree of iodine deficiency and of its control. An increased frequency of thyroid-stimulating hormone (TSH) measurements above 5 mIU/L in newborn screening corresponds to the impaired iodine status of the population. The aim: to estimate the iodine deficiency and the effectiveness of iodine prophylaxis in Krasnoyarsk territory, Republics of Tuva and Khakassia according the results of neonatal TSH_screening. Methods: An 18-year analysis was performed in 34,980 newborns participating in the national thyroid newborn screening program. The TSH concentration was measured in dry blood spots collected by heel stick on filter paper, 96 hours after birth, using DELFIA method. Results: According to the data of the congenital hypothyroidism screening the rate of TSH < 5 mU/1 was 11.8% in Krasnoyarsk territory (23.9% in 2000) and corresponded to mild iodine deficiency. In different regions of Krasnoyarsk territory the rate of TSH < 5 mU/1 in the newborn varied from 3.5% to 23.7%. The highest values were marked in the Arctic peninsula Taimyr, in cities Zheleznogorsk (nuclear facility) and Sosnovoborsk, in Irbeysky, Suchobuzimsky, Eniseysky, Tuchtetsky, Novoselovsky regions (20.9–23.7%). In the Republic of Khakasia the rate of TSH < 5 mU/1 was 12.5%. In the Republic of Tyva the rate of TSH < 5 mU/1 was – 6.6% (38.6% in 1997; 11.5% in 2000). These results indicate mild iodine deficiency. Conclusion: Our investigations show mild iodine deficiency in Central Siberia demanding continuous adequate iodine prevention. Additional assessment of the iodine intake in the regions with mild iodine deficiency is needed to prevent suboptimal cognitive and psychomotor outcomes.

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Increased iodine deficiency in Victoria, Australia: analysis of neonatal thyroid‐stimulating hormone data, 2001 to 2006

The Medical Journal of Australia ◽

10.5694/j.1326-5377.2011.tb03783.x ◽

2011 ◽

Vol 194 (4) ◽

pp. 209-210

Author(s):

Ashequr Rahman ◽

Gayle S Savige ◽

Nicholas J Deacon ◽

Ivan Francis ◽

Janice E Chesters

Keyword(s):

Iodine Deficiency ◽

Thyroid Stimulating Hormone ◽

Stimulating Hormone

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Cord blood thyroid-stimulating hormone and free T4 levels in Turkish neonates: Is iodine deficiency still a continuing problem?

Pediatrics International ◽

10.1111/j.1442-200x.2010.03169.x ◽

2010 ◽

Vol 52 (5) ◽

pp. 762-768 ◽

Cited By ~ 8

Author(s):

Fatih Kışlal ◽

Semra Çetinkaya ◽

Uğur Dilmen ◽

Handan Yaşar ◽

Tahsin Teziç

Keyword(s):

Cord Blood ◽

Iodine Deficiency ◽

Thyroid Stimulating Hormone ◽

Free T4 ◽

Stimulating Hormone

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Increased iodine deficiency in Victoria, Australia: analysis of neonatal thyroid‐stimulating hormone data, 2001 to 2006

The Medical Journal of Australia ◽

10.5694/j.1326-5377.2010.tb04032.x ◽

2010 ◽

Vol 193 (9) ◽

pp. 503-505 ◽

Cited By ~ 8

Author(s):

Ashequr Rahman ◽

Gayle S Savige ◽

Nicholas J Deacon ◽

Ivan Francis ◽

Janice E Chesters

Keyword(s):

Iodine Deficiency ◽

Thyroid Stimulating Hormone ◽

Stimulating Hormone

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Increased iodine deficiency in Victoria, Australia: analysis of neonatal thyroid‐stimulating hormone data, 2001 to 2006

The Medical Journal of Australia ◽

10.5694/j.1326-5377.2011.tb03782.x ◽

2011 ◽

Vol 194 (4) ◽

pp. 209-210 ◽

Cited By ~ 3

Author(s):

Bridget M Wilcken ◽

Veronica C Wiley

Keyword(s):

Iodine Deficiency ◽

Thyroid Stimulating Hormone ◽

Stimulating Hormone

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Assesment of Iodine Deficiency in Patients with Nodular Goiter Living in the Precarpatian Region

Archive of Clinical Medicine ◽

10.21802/acm.2021.1.10 ◽

2021 ◽

Vol 27 (1) ◽

Author(s):

Lilija Rybchak

Keyword(s):

Iodine Deficiency ◽

Randomized Study ◽

Nodular Goiter ◽

State Institution ◽

Iodine Concentration ◽

Thyroid Stimulating Hormone ◽

The State ◽

Average Value ◽

Iodine Excretion ◽

Stimulating Hormone

The objective of the research was to assess the state of iodine supply of patients with nodular goiter living in the Precarpathian region. Materials and methods: 56 patients with nodular goiter were examined (38 women and 18 men), the average age of patients was 48 years. WHO / UNICEF / ICCIDD guidelines were used to assess the severity of iodine deficiency: goiter frequency according to palpation and ultrasound examinations, median of iodine excretion in urine, thyroid-stimulating hormone (TSH) and thyroglobulin levels. Determination of iodine concentration in urine was conducted by the method of “blind”, closed randomized study in single portions of urine according to the Sandell-Kolthoff reaction by the method of Dunn et al. in the laboratory of epidemiology of endocrine diseases at the State Institution “V.P. Komisarenko Institute of Endocrinology and Metabolism” (supervisor – Professor VI Kravchenko). Results. According to the results of the study of iodine in the urine, the data with an average value of 85.9 μg/l were obtained. The median of thyroglobulin serum was in the range of 12.27 ng/L. Levels of thyroid-stimulating hormone were average in patients with nodular goiter of I and II grades constituting 3.13 mU/l (table 2). The level of thyroglobulin median was noted to be the highest in patients with thyroid size corresponding to grade II. Conclusions. The results of the study of iodine in the urine of patients with nodular goiter of grades I and II living in the Precarpathian region indicated a mild level of iodine deficiency. The presence of iodine deficiency necessitated both mass (the use of iodized salt by the population) and individual iodine prevention (prescribing potassium iodide).

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Newborn Screening for Thyroid-stimulating Hormone as an Indicator for Assessment of Iodine Status in the Republic of Macedonia

Journal of Medical Biochemistry ◽

10.1515/jomb-2016-0023 ◽

2016 ◽

Vol 35 (4) ◽

pp. 385-389 ◽

Cited By ~ 4

Author(s):

Violeta Anastasovska ◽

Mirjana Kocova

Keyword(s):

Newborn Screening ◽

Iodine Deficiency ◽

Screening Program ◽

Iodine Intake ◽

Thyroid Stimulating Hormone ◽

Iodine Status ◽

The Republic ◽

National Prevalence ◽

Iodine Sufficiency ◽

Stimulating Hormone

SummaryBackground:Iodine deficiency is associated with goiter and impaired brain function leading to cretinism. An increased frequency of thyroid-stimulating hormone (TSH) measurements above 5 mIU/L on newborn screening points toward an impaired iodine status of the population.Methods:A 13-year retrospective analysis was performed in 228,266 newborns participating in the national thyroid newborn screening program. The TSH concentration was measured in dry blood spots collected by heel stick on filter paper, 48 hours after birth, using fluoroimmunometric DELFIA method.Results:Out of 236,378 live-born infants, 228,266 (96.6%) have been screened for TSH, of which 198,213 (86.8%) were retrospectively evaluated for TSH levels above 5 mIU/L. Neonates with congenital hypothyroidism, prematurity, and low birth weight were excluded from the evaluation, as well as the inadequately sampled neonates (13.2%). A national prevalence of 3.08% newborns (n=6,105) with TSH > 5 mIU/L was found. Higher percentages were noted in two regions of the country, indicating possible mild iodine deficiency in these regions and shifting the overall average to above 3%.Conclusions:Our results indicate overall iodine sufficiency in the Macedonian population. Additional assessment of the iodine intake in the regions with suspected mild iodine deficiency is needed to prevent suboptimal cognitive and psychomotor outcomes.

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Neonatal iodine status survey by thyroid-stimulating hormone screening in Surabaya

Paediatrica Indonesiana ◽

10.14238/pi52.5.2012.289-93 ◽

2012 ◽

Vol 52 (5) ◽

pp. 289

Author(s):

Connie Untario ◽

I Wayan Bikin Suryawan

Keyword(s):

Iodine Deficiency ◽

Thyroid Stimulating Hormone ◽

Iodine Deficiency Disorders ◽

Cross Sectional ◽

International Council ◽

Iodine Status ◽

Thyroid Screening ◽

Healthy Infants ◽

Study Population ◽

Stimulating Hormone

Background Iodine deficiency disorders (lDD) are a significantpublic health problem globally. Iodine deficiency may causesubclinical hypothyroidism during pregnancy and early infancy.Neonatal thyroid screening of serum thyroid􀁊stimulating hormone(TSH) to detect hypothyroidism may also be used to determinethe prevalence of IDD in a population. Previous studies reportedmild ID D status in different parts of Indonesia.Objective To evaluate the iodine status of neonates born inMitra K eluarga Surabaya Hospital (MKSH) by TSH screeningover a 6􀁊year period.Methods T his is a cross􀁊sectional and hospital􀁊based studyconducted in MKSH from January 2005 to December 2010. Ofthe 5,619 infants born in MKSH during the study period, 3,349(59.6%) healthy infants took part in this study. Blood specimensfor TSH measurement were collected from subjects 2 to 6 daysafter birth, and sent to a reference laboraratory for evaluation.Using the neonatal TSH values, the iodine deficiency level ofthe group was determined according to the WHO/UNICEF/International Council for the Control of IDD criteria.Results A total of 3,349 newborn babies underwent neonatalTSH screening in MKSH. Subjects' mean TSH concentrationwas 5.14 mIU!L. A TSH concentration> SmIU!L was found in1270 (37.9%) subjects, 166 (27.6%) in 2005, 252 (44.0%) in 2006,331 (47.1 %) in 2007, 356 (57.7%) in 2008, 114 (20.7%) in 2009and 51 (16.8%) in 2010. On the basis of the WHO/UNICEF/International Council for the Control of Iodine DeficiencyDisorder criteria, this frequency corresponded to a moderate levelof IDD. Twenty􀁊two neonates had TSH > 20 mIU!L from which2 infants were confirmed positive for hypothyroidism.Conclusion A 6􀁊year study of 3,349 newborns screened for TSHrevealed that 37.9% of subjects had TSH concentration of morethan SmIU!L. This frequency indicates a moderate level of IDDin the study population. [Paediatr Indones. 2012;52:289,93].

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