scholarly journals Newborn Screening for Thyroid-stimulating Hormone as an Indicator for Assessment of Iodine Status in the Republic of Macedonia

2016 ◽  
Vol 35 (4) ◽  
pp. 385-389 ◽  
Author(s):  
Violeta Anastasovska ◽  
Mirjana Kocova
Keyword(s):  
Newborn Screening ◽  
Iodine Deficiency ◽  
Screening Program ◽  
Iodine Intake ◽  
Thyroid Stimulating Hormone ◽  
Iodine Status ◽  
The Republic ◽  
National Prevalence ◽  
Iodine Sufficiency ◽  
Stimulating Hormone

SummaryBackground:Iodine deficiency is associated with goiter and impaired brain function leading to cretinism. An increased frequency of thyroid-stimulating hormone (TSH) measurements above 5 mIU/L on newborn screening points toward an impaired iodine status of the population.Methods:A 13-year retrospective analysis was performed in 228,266 newborns participating in the national thyroid newborn screening program. The TSH concentration was measured in dry blood spots collected by heel stick on filter paper, 48 hours after birth, using fluoroimmunometric DELFIA method.Results:Out of 236,378 live-born infants, 228,266 (96.6%) have been screened for TSH, of which 198,213 (86.8%) were retrospectively evaluated for TSH levels above 5 mIU/L. Neonates with congenital hypothyroidism, prematurity, and low birth weight were excluded from the evaluation, as well as the inadequately sampled neonates (13.2%). A national prevalence of 3.08% newborns (n=6,105) with TSH > 5 mIU/L was found. Higher percentages were noted in two regions of the country, indicating possible mild iodine deficiency in these regions and shifting the overall average to above 3%.Conclusions:Our results indicate overall iodine sufficiency in the Macedonian population. Additional assessment of the iodine intake in the regions with suspected mild iodine deficiency is needed to prevent suboptimal cognitive and psychomotor outcomes.

scholarly journals Neonatal Thyroid-Stimulating Hormone Screening as an Indirect Method for the Assessment of Iodine Status in Central Siberia

2018 ◽  
Vol 3 (4) ◽  
Keyword(s):  
Newborn Screening ◽  
Congenital Hypothyroidism ◽  
Iodine Deficiency ◽  
Screening Program ◽  
Thyroid Stimulating Hormone ◽  
The Arctic ◽  
Central Siberia ◽  
Iodine Status ◽  
The Republic ◽  
Stimulating Hormone

Background: Iodine deficiency is associated with goiter and impaired brain function. Neonatal thyroid-stimulating hormone (TSH) screening for congenital hypothyroidism used as an indicator of the degree of iodine deficiency and of its control. An increased frequency of thyroid-stimulating hormone (TSH) measurements above 5 mIU/L in newborn screening corresponds to the impaired iodine status of the population. The aim: to estimate the iodine deficiency and the effectiveness of iodine prophylaxis in Krasnoyarsk territory, Republics of Tuva and Khakassia according the results of neonatal TSH_screening. Methods: An 18-year analysis was performed in 34,980 newborns participating in the national thyroid newborn screening program. The TSH concentration was measured in dry blood spots collected by heel stick on filter paper, 96 hours after birth, using DELFIA method. Results: According to the data of the congenital hypothyroidism screening the rate of TSH < 5 mU/1 was 11.8% in Krasnoyarsk territory (23.9% in 2000) and corresponded to mild iodine deficiency. In different regions of Krasnoyarsk territory the rate of TSH < 5 mU/1 in the newborn varied from 3.5% to 23.7%. The highest values were marked in the Arctic peninsula Taimyr, in cities Zheleznogorsk (nuclear facility) and Sosnovoborsk, in Irbeysky, Suchobuzimsky, Eniseysky, Tuchtetsky, Novoselovsky regions (20.9–23.7%). In the Republic of Khakasia the rate of TSH < 5 mU/1 was 12.5%. In the Republic of Tyva the rate of TSH < 5 mU/1 was – 6.6% (38.6% in 1997; 11.5% in 2000). These results indicate mild iodine deficiency. Conclusion: Our investigations show mild iodine deficiency in Central Siberia demanding continuous adequate iodine prevention. Additional assessment of the iodine intake in the regions with mild iodine deficiency is needed to prevent suboptimal cognitive and psychomotor outcomes.

scholarly journals Incidence and Interrelated Factors in Patients With Congenital Hypothyroidism as Detected by Newborn Screening in Guangxi, China

2015 ◽  
Vol 2 ◽  
pp. 2333794X1456719 ◽  
Author(s):  
Xin Fan ◽  
Shaoke Chen ◽  
Jiale Qian ◽  
Suren Sooranna ◽  
Jingi Luo ◽  
...  
Keyword(s):  
Newborn Screening ◽  
Congenital Hypothyroidism ◽  
Screening Program ◽  
Thyroid Stimulating Hormone ◽  
Who Guidelines ◽  
Newborn Screening Program ◽  
Study Results ◽  
Stimulating Hormone

Background. A newborn screening program (NSP) for congenital hypothyroidism (CH) was carried out in Guangxi in order to understand the incidence of CH and the factors interrelated to major types of CH in this region of China. Methods. During 2009 to 2013, data from 930 612 newborns attending NSP in Guangxi were collected. Patients were classified with either permanent CH (PCH) or transient CH (TCH) after 2 years of progressive study. Results. A total of 1210 patients were confirmed with CH with an incidence of 1/769, including 68 PCH and 126 TCH cases with incidences of 1/6673 and 1/3385, respectively. The frequency of thyroid stimulating hormone values greater than 5 mIU/L was 7.2%, which, based on WHO guidelines, suggests that the population was mildly iodine deficient. Conclusions. The incidence of CH was high in Guangxi. Approximately two thirds of CH patients were TCH, which may be due to a deficiency in iodine within the population.

Transient Neonatal Hypothyroidism Detected by Newborn Screening Program

PEDIATRICS ◽  
1977 ◽  
Vol 60 (4) ◽  
pp. 538-541
Author(s):  
STEPHEN H. LAFRANCHI ◽  
NEIL R. M. BUIST ◽  
WILLIAM H. MURPHEY ◽  
P. REED LARSEN ◽  
THOMAS P. FOLEY
Keyword(s):  
Newborn Screening ◽  
Filter Paper ◽  
Metabolic Diseases ◽  
Screening Program ◽  
Newborn Infants ◽  
Thyroid Stimulating Hormone ◽  
Newborn Screening Program ◽  
Neonatal Hypothyroidism ◽  
Blood Samples ◽  
Stimulating Hormone

A screening program for the detection of neonatal hypothyroidism has been in effect in Oregon since May 1975. Blood samples are obtained from all newborn infants to test for phenylketonuria and other metabolic diseases. A second specimen is obtained from more than 90% of these infants who are retested at 4 to 6 weeks of age. These Guthrie filter paper blood samples are analyzed for thyroxine (T4), and all samples with a low T4 value are analyzed for thyroid stimulating hormone (TSH). At the outset of the program, it was speculated that the screening might detect infants who had reduced

scholarly journals Newborn Iodine Status Is Not Related to Congenital Hypothyroidism

2020 ◽  
Vol 150 (9) ◽  
pp. 2429-2434
Author(s):  
James L Mills ◽  
Elijah C Reische ◽  
Kurunthachalam Kannan ◽  
Chongjing Gao ◽  
Gary M Shaw ◽  
...  
Keyword(s):  
United States ◽  
Newborn Screening ◽  
Congenital Hypothyroidism ◽  
Iodine Deficiency ◽  
Neonatal Intensive Care ◽  
Screening Program ◽  
Iodine Concentration ◽  
The United States ◽  
Dried Blood Spots ◽  
Iodine Status

ABSTRACT Background Severe iodine deficiency or excess during pregnancy can cause congenital hypothyroidism (CH). Iodine deficiency is common in pregnant women in the United States. Objectives We conducted a nested case–control study in a cohort of ∼2.5 million births in California to determine whether iodine status is related to CH in a US population. Methods Dried blood spots from 907 newborns with CH identified by newborn screening and 909 unaffected controls matched by month of birth were obtained from the California Newborn Screening Program to measure whole-blood iodine concentration. Iodine status was compared between cases and controls, and logistic regression was used to assess the association between CH status and blood iodine concentrations. Iodine status was also compared between cases and controls among infants treated in a neonatal intensive care unit (NICU) because CH has been reported in infants exposed to high levels of iodine in the NICU. Results Blood iodine concentrations did not differ significantly between cases (median: 20.0 ng/mL; IQR: 12.1–29.8 ng/mL) and controls (median: 20.3 ng/mL; IQR: 12.5–30.9 ng/mL; P = 0.59). Neither extremely high nor extremely low blood iodine concentrations (1st, 5th, 95th, and 99th percentiles of the distribution) were more common in cases. Among infants treated in NICUs, however, cases had significantly (P = 0.01) higher iodine (median: 22.7 ng/mL; IQR: 16.4–32.1 ng/mL) compared with controls (median: 17.3 ng/mL; IQR: 8.3–26.6 ng/mL). Conclusions CH cases did not have significantly higher or lower iodine in this population, which is reassuring given that maternal iodine deficiency is common in the United States. Among newborns in the NICU, CH cases had higher blood iodine concentrations compared with controls, suggesting that excess iodine exposure in the NICU could be causing CH. It may be beneficial to monitor iodine exposure from surgical procedures, imaging, and iodine-containing disinfectants and to consider non-iodine alternatives.

scholarly journals Dynamic monitoring of iodine sufficiency in Belarus: results and problems

2018 ◽  
Vol 64 (3) ◽  
pp. 170-179 ◽  
Author(s):  
Tatiana V. Mokhort ◽  
Natalia D. Kolomiets ◽  
Sergei V. Petrenko ◽  
Ekaterina V. Fedorenko ◽  
Alena G. Mokhort
Keyword(s):  
Iodine Deficiency ◽  
Salt Intake ◽  
Iodine Intake ◽  
Global Network ◽  
Dynamic Monitoring ◽  
School Age Children ◽  
Negative Consequences ◽  
Governmental Organization ◽  
The Republic ◽  
Iodine Sufficiency

The strategy for elimination of iodine deficiency in the population was developed and implemented in the Republic of Belarus. It is based on acceptance of recommendations that iodized salt is a unique source of iodine support. Currently, adequate iodine consumption is achieved. The prevalence of thyroid gland diseases caused by iodine deficiency was significantly decreased. In 2013, the International Council for Control of Iodine Deficiency Disorders (ICCIDD), a global non-profit non-governmental organization established to eliminate iodine deficiency and its negative consequences, published the results of iodine status assessment in the world. According to these data, the Republic of Belarus provides adequate iodine intake. In 2016, Iodine Global Network published maps characterizing iodine supply for the two main categories — school-age children and pregnant females. These data have confirmed that the Republic of Belarus refers to countries with sufficient iodine consumption according to the results of subnational studies. Despite the achieved successes, new issues are raised: quality of iodine sufficiency monitoring, risks of excessive salt intake, and need for new approaches to diagnosing thyroid pathology due to iodine deficiency.

scholarly journals Neonatal iodine status survey by thyroid-stimulating hormone screening in Surabaya

2012 ◽  
Vol 52 (5) ◽  
pp. 289
Author(s):  
Connie Untario ◽  
I Wayan Bikin Suryawan
Keyword(s):  
Iodine Deficiency ◽  
Thyroid Stimulating Hormone ◽  
Iodine Deficiency Disorders ◽  
Cross Sectional ◽  
International Council ◽  
Iodine Status ◽  
Thyroid Screening ◽  
Healthy Infants ◽  
Study Population ◽  
Stimulating Hormone

Background Iodine deficiency disorders (lDD) are a significantpublic health problem globally. Iodine deficiency may causesubclinical hypothyroidism during pregnancy and early infancy.Neonatal thyroid screening of serum thyroid􀁊stimulating hormone(TSH) to detect hypothyroidism may also be used to determinethe prevalence of IDD in a population. Previous studies reportedmild ID D status in different parts of Indonesia.Objective To evaluate the iodine status of neonates born inMitra K eluarga Surabaya Hospital (MKSH) by TSH screeningover a 6􀁊year period.Methods T his is a cross􀁊sectional and hospital􀁊based studyconducted in MKSH from January 2005 to December 2010. Ofthe 5,619 infants born in MKSH during the study period, 3,349(59.6%) healthy infants took part in this study. Blood specimensfor TSH measurement were collected from subjects 2 to 6 daysafter birth, and sent to a reference laboraratory for evaluation.Using the neonatal TSH values, the iodine deficiency level ofthe group was determined according to the WHO/UNICEF/International Council for the Control of IDD criteria.Results A total of 3,349 newborn babies underwent neonatalTSH screening in MKSH. Subjects' mean TSH concentrationwas 5.14 mIU!L. A TSH concentration> SmIU!L was found in1270 (37.9%) subjects, 166 (27.6%) in 2005, 252 (44.0%) in 2006,331 (47.1 %) in 2007, 356 (57.7%) in 2008, 114 (20.7%) in 2009and 51 (16.8%) in 2010. On the basis of the WHO/UNICEF/International Council for the Control of Iodine DeficiencyDisorder criteria, this frequency corresponded to a moderate levelof IDD. Twenty􀁊two neonates had TSH > 20 mIU!L from which2 infants were confirmed positive for hypothyroidism.Conclusion A 6􀁊year study of 3,349 newborns screened for TSHrevealed that 37.9% of subjects had TSH concentration of morethan SmIU!L. This frequency indicates a moderate level of IDDin the study population. [Paediatr Indones. 2012;52:289,93].

Maternal iodine status and neonatal thyroid-stimulating hormone concentration: a community survey in Songkhla, southern Thailand

2009 ◽  
Vol 12 (12) ◽  
pp. 2279-2284 ◽  
Author(s):  
Somchit Jaruratanasirikul ◽  
Pasuree Sangsupawanich ◽  
Ounjai Koranantakul ◽  
Prasin Chanvitan ◽  
Prasit Ruaengrairatanaroj ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Iodine Deficiency ◽  
Urinary Iodine ◽  
Iodine Intake ◽  
Thyroid Stimulating Hormone ◽  
Iodized Salt ◽  
Urinary Iodine Excretion ◽  
Southern Thailand ◽  
Iodine Excretion ◽  
Stimulating Hormone

AbstractObjectiveTo determine iodine intake and urinary iodine excretion (UIE) in a group of pregnant Thai women and the concentration of thyroid-stimulating hormone (TSH) in their neonates.DesignA prospective cohort study.SettingThree districts of Songkhla, southern Thailand.SubjectsTwo hundred and thirty-six pregnant women.ResultsA quarter of the participants lacked knowledge of iodine and the prevention of iodine deficiency, although 70 % used iodized salt. Those who did not use iodized salt stated that they had no knowledge about iodine (57 %) and no iodized salt was sold in their village (36 %). The median iodine intake in the three districts was 205–240 μg/d, with 53–74 % of pregnant women having iodine intake <250 μg/d. The median UIE in the three districts was 51–106 μg/l, with 24–35 % having UIE < 50 μg/l. The mean neonatal TSH was 2·40 (sd1·56) mU/l, with 8·9 % of neonates having TSH > 5 mU/l.ConclusionsThe studied women and their fetuses were at risk of mild iodine deficiency. About a quarter of the participants lacked knowledge of the importance of iodine. Education regarding the importance of iodine supplements and the promotion of iodized salt should be added to national health-care policies in order to prevent iodine-deficiency disorders, diseases that are subclinical but have long-term sequelae.

scholarly journals Comparison of iodine status pre- and post-mandatory iodine fortification of bread in South Australia: a population study using newborn thyroid-stimulating hormone concentration as a marker

2019 ◽  
Vol 22 (16) ◽  
pp. 3063-3072 ◽  
Author(s):  
Molla Mesele Wassie ◽  
Lisa N Yelland ◽  
Lisa G Smithers ◽  
Enzo Ranieri ◽  
Shao Jia Zhou
Keyword(s):  
Iodine Deficiency ◽  
Urinary Iodine ◽  
South Australia ◽  
Interrupted Time Series ◽  
Iodine Concentration ◽  
Thyroid Stimulating Hormone ◽  
Transitional Period ◽  
Urinary Iodine Concentration ◽  
Iodine Status ◽  
Stimulating Hormone

AbstractObjective:The present study aimed to evaluate the effect of mandatory iodine fortification of bread on the iodine status of South Australian populations using newborn thyroid-stimulating hormone (TSH) concentration as a marker.Design:The study used an interrupted time-series design.Setting:TSH data collected between 2005 and 2016 (n 211 033) were extracted from the routine newborn screening programme in South Australia for analysis. Iodine deficiency is indicated when more than 3 % of newborns have TSH > 5 mIU/l.Participants:Newborns were classified into three groups: the pre-fortification group (those born before October 2009); the transition group (born between October 2009 and June 2010); and the post-fortification group (born after June 2010).Results:The percentage of newborns with TSH > 5 mIU/l was 5·1, 6·2 and 4·6 % in the pre-fortification, transition and post-fortification groups, respectively. Based on a segmented regression model, newborns in the post-fortification period had a 10 % lower risk of having TSH > 5 mIU/l than newborns in the pre-fortification group (incidence rate ratio (IRR) = 0·90; 95 % CI 0·87, 0·94), while newborns in the transitional period had a 22 % higher risk of having TSH > 5 mIU/l compared with newborns in the pre-fortification period (IRR = 1·22; 95 % CI 1·13, 1·31).Conclusions:Using TSH as a marker, South Australia would be classified as mild iodine deficiency post-fortification in contrast to iodine sufficiency using median urinary iodine concentration as a population marker. Re-evaluation of the current TSH criteria to define iodine status in populations is warranted in this context.

scholarly journals The results of neonatal TSH screening do not agree with indicators of the optimal iodine status of pregnant women in the Republic of Georgia

2018 ◽  
Vol 14 (2) ◽  
pp. 81-85 ◽  
Author(s):  
Nelli Barnabishvilli ◽  
Gregory A. Gerasimov ◽  
Teimuraz Azikuri
Keyword(s):  
Iodine Deficiency ◽  
Endemic Goiter ◽  
Thyroid Stimulating Hormone ◽  
Capital City ◽  
Iodine Nutrition ◽  
Iodine Status ◽  
Significant Difference ◽  
High Prevalence ◽  
The Republic ◽  
Tsh Levels

Background. Georgia historically was a country with moderate to severe iodine deficiency and high prevalence of endemic goiter. A representative countrywide iodine survey conducted in Georgia in 2017 confirmed optimal iodine nutrition of the population with median UIC 298 mcg/L in SAC and 211 mcg/L in PW. Aim. The aim of this study was to assess status of iodine nutrition of population in Georgia. Methods. The assesement based on the proportion of neonatal Thyroid-Stimulating Hormone (TSH) levels >5mIU/L from 2009 to 2015 and compare these data with the results of direct assessment of iodine status made during the 2017 national survey. Results. From 2009 to 2015 the proportion of newborns with TSH >20 mIU/L decreased threefold: from 0.45 to 0.15%. This trend was observed in all regions of the country with significant difference between the capital city and Western in Eastern parts of the country. There has been also significant reduction of the prevalence of TSH >5 mIU/L in Georgia from 4.46% in 2009 to 3.5% in 2015. However, only in Tbilisi the frequency of elevated TSH was below 3% – the cutoff level for adequate iodine nutrition. In other regions (Western and Eastern Georgia) prevalence of TSH >5 mIU/L was 3.8% and 4.4% respectively that could be falsely interpreted as mild iodine deficiency. Conclusions. Although neonatal TSH is useful to detect moderate to severe iodine deficiency, it should be cautiously recommended for the evaluation of iodine status in iodine sufficient to mildly iodine deficient regions.

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