Age Related Macular Degeneration - The Recent Advances in Basic Research and Clinical Care

10.5772/1051 ◽  
2012 ◽  
Keyword(s):  
Macular Degeneration ◽  
Clinical Care ◽  
Basic Research ◽  
Age Related Macular Degeneration ◽  
Recent Advances ◽  
Age Related

scholarly journals Age-Related Macular Degeneration Revisited: From Pathology and Cellular Stress to Potential Therapies

2021 ◽  
Vol 8 ◽  
Author(s):  
Majda Hadziahmetovic ◽  
Goldis Malek
Keyword(s):  
Macular Degeneration ◽  
Vision Loss ◽  
Clinical Care ◽  
Retinal Pigment ◽  
Retinal Pigment Epithelial Cells ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
The Impact

Age-related macular degeneration (AMD) is a neurodegenerative disease of the aging retina, in which patients experience severe vision loss. Therapies available to patients are limited and are only effective in a sub-population of patients. Future comprehensive clinical care depends on identifying new therapeutic targets and adopting a multi-therapeutic approach. With this goal in mind, this review examines the fundamental concepts underlying the development and progression of AMD and re-evaluates the pathogenic pathways associated with the disease, focusing on the impact of injury at the cellular level, with the understanding that critical assessment of the literature may help pave the way to identifying disease-relevant targets. During this process, we elaborate on responses of AMD vulnerable cells, including photoreceptors, retinal pigment epithelial cells, microglia, and choroidal endothelial cells, based on in vitro and in vivo studies, to select stressful agents, and discuss current therapeutic developments in the field, targeting different aspects of AMD pathobiology.

scholarly journals Discovering the Potential of Natural Antioxidants in Age-Related Macular Degeneration: A Review

2022 ◽  
Vol 15 (1) ◽  
pp. 101
Author(s):  
Kah-Hui Wong ◽  
Hui-Yin Nam ◽  
Sze-Yuen Lew ◽  
Murali Naidu ◽  
Pamela David ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Vision Loss ◽  
Web Of Science ◽  
Clinical Care ◽  
Natural Antioxidants ◽  
Age Related Macular Degeneration ◽  
Anatomical Changes ◽  
Age Related ◽  
Disease Stages ◽  
Whole Foods

Age-related macular degeneration (AMD) is a multifactorial disease associated with anatomical changes in the inner retina. Despite tremendous advances in clinical care, there is currently no cure for AMD. This review aims to evaluate the published literature on the therapeutic roles of natural antioxidants in AMD. A literature search of PubMed, Web of Science and Google Scholar for peer-reviewed articles published between 1 January 2011 and 31 October 2021 was undertaken. A total of 82 preclinical and 18 clinical studies were eligible for inclusion in this review. We identified active compounds, carotenoids, extracts and polysaccharides, flavonoids, formulations, vitamins and whole foods with potential therapeutic roles in AMD. We evaluated the integral cellular signaling pathways including the activation of antioxidant pathways and angiogenesis pathways orchestrating their mode of action. In conclusion, we examined the therapeutic roles of natural antioxidants in AMD which warrant further study for application in clinical practice. Our current understanding is that natural antioxidants have the potential to improve or halt the progression of AMD, and tailoring therapeutics to the specific disease stages may be the key to preventing irreversible vision loss.

scholarly journals Recent advances in the treatment of age-related macular degeneration

2008 ◽  
Vol 58 (550) ◽  
pp. 309-310
Author(s):  
Ameenat Lola Solebo ◽  
Romesh I Angunawela ◽  
Samipa Dasgupta ◽  
John Marshall
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Recent Advances ◽  
Age Related

scholarly journals Mechanism of Inflammation in Age-Related Macular Degeneration: An Up-to-Date on Genetic Landmarks

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Francesco Parmeggiani ◽  
Francesco S. Sorrentino ◽  
Mario R. Romano ◽  
Ciro Costagliola ◽  
Francesco Semeraro ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Complex Disease ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Basic Research ◽  
Cholesterol Homeostasis ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Immune Mediated

Age-related macular degeneration (AMD) is the most common cause of irreversible visual impairment among people over 50 years of age, accounting for up to 50% of all cases of legal blindness in Western countries. Although the aging represents the main determinant of AMD, it must be considered a multifaceted disease caused by interactions among environmental risk factors and genetic backgrounds. Mounting evidence and/or arguments document the crucial role of inflammation and immune-mediated processes in the pathogenesis of AMD. Proinflammatory effects secondary to chronic inflammation (e.g., alternative complement activation) and heterogeneous types of oxidative stress (e.g., impaired cholesterol homeostasis) can result in degenerative damages at the level of crucial macular structures, that is photoreceptors, retinal pigment epithelium, and Bruch’s membrane. In the most recent years, the association of AMD with genes, directly or indirectly, involved in immunoinflammatory pathways is increasingly becoming an essential core for AMD knowledge. Starting from the key basic-research notions detectable at the root of AMD pathogenesis, the present up-to-date paper reviews the best-known and/or the most attractive genetic findings linked to the mechanisms of inflammation of this complex disease.

scholarly journals How the Comparison of Age-related Macular Degeneration Treatments Trial Results Will Impact Clinical Care

2011 ◽  
Vol 152 (4) ◽  
pp. 509-514 ◽  
Author(s):  
Janet Davis ◽  
Timothy W. Olsen ◽  
Michael Stewart ◽  
Paul Sternberg
Keyword(s):  
Macular Degeneration ◽  
Clinical Care ◽  
Age Related Macular Degeneration ◽  
Age Related
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