scholarly journals Basic Research and Clinical Application of Drug Delivery Systems for the Treatment of Age-Related Macular Degeneration

10.5772/31524 ◽  
2012 ◽  
Author(s):  
Giuseppe Lo ◽  
Alessandro Gal
Keyword(s):  
Drug Delivery ◽  
Macular Degeneration ◽  
Clinical Application ◽  
Drug Delivery Systems ◽  
Basic Research ◽  
Delivery Systems ◽  
Age Related Macular Degeneration ◽  
Age Related

Intravitreal anti-VEGF drug delivery systems for age-related macular degeneration

2020 ◽  
Vol 573 ◽  
pp. 118767 ◽  
Author(s):  
Andrea Luaces-Rodríguez ◽  
Cristina Mondelo-García ◽  
Irene Zarra-Ferro ◽  
Miguel González-Barcia ◽  
Pablo Aguiar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Macular Degeneration ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Age Related Macular Degeneration ◽  
Anti Vegf ◽  
Age Related

Advanced Hydrogels Based Drug Delivery Systems for Ophthalmic Delivery

2020 ◽  
Vol 13 (4) ◽  
pp. 291-300 ◽  
Author(s):  
Srividya Gorantla ◽  
Tejashree Waghule ◽  
Vamshi Krishna Rapalli ◽  
Prem Prakash Singh ◽  
Sunil Kumar Dubey ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Age Related Macular Degeneration ◽  
Stimuli Responsive ◽  
Duration Of Action ◽  
Age Related ◽  
Aqueous Gels ◽  
Ophthalmic Delivery ◽  
3D Printed

Hydrogels are aqueous gels composed of cross-linked networks of hydrophilic polymers. Stimuli-responsive based hydrogels have gained focus over the past 20 years for treating ophthalmic diseases. Different stimuli-responsive mechanisms are involved in forming polymer hydrogel networks, including change in temperature, pH, ions, and others including light, thrombin, pressure, antigen, and glucose-responsive. Incorporation of nanocarriers with these smart stimuli-responsive drug delivery systems that can extend the duration of action by increasing ocular bioavailability and reducing the dosing frequency. This review will focus on the hydrogel drug delivery systems highlighting the gelling mechanisms and emerging stimuli-responsive hydrogels from preformed gels, nanogels, and the role of advanced 3D printed hydrogels in vision-threatening diseases like age-related macular degeneration and retinitis pigmentosa. It also provides insight into the limitations of hydrogels along with the safety and biocompatibility of the hydrogel drug delivery systems.

scholarly journals Novel delivery systems of active substances for intraocular administration

2021 ◽  
Vol 87 (87(03)) ◽  
pp. 331-338
Author(s):  
Rocío Herrero Vanrell
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
The Elderly ◽  
Delivery Systems ◽  
Posterior Segment ◽  
Age Related Macular Degeneration ◽  
Multifactorial Diseases ◽  
Age Related ◽  
Intraocular Drug Delivery ◽  
Active Substances

Neurodegenerative pathologies affecting the posterior segment of the eye such as diabetic retinopathy, age related macular degeneration and glaucoma are among the main causes of blindness in the world. They have in common that are cronic, multifactorial and in some cases related with the elderly. The treatment of these pathologies require to maintain therapeutic concentrations in the posterior segment thanks to the use of successive intraocular injections which are associated to secondary effects being poor tolerated by patients. Intraocular drug delivery systems emerged as an alternative to frequent injections as they are able to deliver the therapeutic agent in a controlled fashion into the eye after a single administration. Depending on the biomaterial these delivery systems are biodegradable or non biodegradable. Attending to their sizes, drug delivery systems are classified in implants (>1mm), microsystems (1-1000μm) y nanosystems (1-1000nm). Biodegradable microspheres emerge as therapeutic tools of great interest for the treatment of neurodegenerative pathologies as they can encapsulate active substances of distinct nature and provide release profiles tailoring with clinical needs. Furthermore, it is possible to administer different amounts of microspheres which correspond to the most adequated doses of the medicine in a personalized therapy. The simultaneous encapsulation of several active substances in the microspheres are of great interest in the treatment of multifactorial diseases covering different therapeutic targets.

scholarly journals Ophthalmic Drug Delivery Systems for the Treatment of Retinal Diseases: Basic Research to Clinical Applications

2010 ◽  
Vol 51 (11) ◽  
pp. 5403 ◽  
Author(s):  
Henry F. Edelhauser ◽  
Cheryl L. Rowe-Rendleman ◽  
Michael R. Robinson ◽  
Daniel G. Dawson ◽  
Gerald J. Chader ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Basic Research ◽  
Delivery Systems ◽  
Clinical Applications ◽  
Retinal Diseases ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug

Dual-sensitive dual-prodrug nanoparticles with light-controlled endo/lysosomal escape for synergistic photoactivated chemotherapy

2021 ◽  
Author(s):  
Yubin Huang ◽  
Hongtong Lu ◽  
Shasha He ◽  
Qingfei Zhang ◽  
Xiaoyuan Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Clinical Application ◽  
Drug Delivery Systems ◽  
Controlled Drug Delivery ◽  
Delivery Systems ◽  
Chemotherapeutic Agents

The clinical application of conventional chemotherapeutic agents, represented by cisplatin, is limited by severe side effects. So, it is essential to explore more safer and controlled drug delivery systems for...

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