scholarly journals Role of the Mammalian Target of Rapamycin (mTOR) Signalling Pathway in Podocytes in Glomerular Disease

10.5772/24141 ◽  
2011 ◽  
Author(s):  
Lena Succar ◽  
David CH ◽  
Gopala K
Keyword(s):  
Mammalian Target Of Rapamycin ◽  
Glomerular Disease ◽  
Signalling Pathway ◽  
Target Of Rapamycin ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway

2003 ◽  
Vol 8 (1) ◽  
pp. 65-79 ◽  
Author(s):  
Naoki Kimura ◽  
Chiharu Tokunaga ◽  
Sushila Dalal ◽  
Christine Richardson ◽  
Ken-ichi Yoshino ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Mammalian Target Of Rapamycin ◽  
Signalling Pathway ◽  
Target Of Rapamycin ◽  
Amp Activated Protein Kinase ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

scholarly journals Role of the mTOR Signalling Pathway in Human Sepsis-Induced Myocardial Dysfunction

2019 ◽  
Vol 35 (7) ◽  
pp. 875-883 ◽  
Author(s):  
Wei Cheng MM ◽  
Yun Long ◽  
Hao Wang ◽  
Wen Han MM ◽  
Jiahui Zhang ◽  
...  
Keyword(s):  
Myocardial Dysfunction ◽  
Signalling Pathway ◽  
Human Sepsis ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

scholarly journals The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation

Genes ◽  
2020 ◽  
Vol 11 (9) ◽  
pp. 1043
Author(s):  
Ivana Bjedov ◽  
Charalampos Rallis
Keyword(s):  
Ribosome Biogenesis ◽  
Complex Trait ◽  
Signalling Pathway ◽  
Target Of Rapamycin ◽  
Cellular Functions ◽  
Pharmacological Interventions ◽  
Age Related ◽  
Energy Sensing ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

Ageing is a complex trait controlled by genes and the environment. The highly conserved mechanistic target of rapamycin signalling pathway (mTOR) is a major regulator of lifespan in all eukaryotes and is thought to be mediating some of the effects of dietary restriction. mTOR is a rheostat of energy sensing diverse inputs such as amino acids, oxygen, hormones, and stress and regulates lifespan by tuning cellular functions such as gene expression, ribosome biogenesis, proteostasis, and mitochondrial metabolism. Deregulation of the mTOR signalling pathway is implicated in multiple age-related diseases such as cancer, neurodegeneration, and auto-immunity. In this review, we briefly summarise some of the workings of mTOR in lifespan and ageing through the processes of transcription, translation, autophagy, and metabolism. A good understanding of the pathway’s outputs and connectivity is paramount towards our ability for genetic and pharmacological interventions for healthy ageing and amelioration of age-related disease.

scholarly journals SG-02 * ROLE OF mTOR SIGNALLING PATHWAY IN THE PATHOGENESIS OF SUBEPENDYMAL GIANT CELL ASTROCYTOMAS

2015 ◽  
Vol 17 (suppl 3) ◽  
pp. iii35-iii35
Author(s):  
M. Sharma ◽  
K. Kumari ◽  
A. Kakkar ◽  
C. Sarkar ◽  
V. Suri ◽  
...  
Keyword(s):  
Giant Cell ◽  
Signalling Pathway ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

Role of the mTOR Signalling Pathway in Experimental Rabbit Vein Grafts

2016 ◽  
Vol 25 (11) ◽  
pp. 1124-1132 ◽  
Author(s):  
Qun Wang ◽  
Li Wan ◽  
Liqiao Liu ◽  
Jichun Liu
Keyword(s):  
Signalling Pathway ◽  
Vein Grafts ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

The role of mTOR signalling pathway in hypoxia-induced cognitive impairment

2020 ◽  
pp. 1-7 ◽  
Author(s):  
Entesar Yaseen Abdo Qaid ◽  
Ninie Nadia Zulkipli ◽  
Rahimah Zakaria ◽  
Asma Hayati Ahmad ◽  
Zahiruddin Othman ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Signalling Pathway ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

scholarly journals Role of the mTOR signalling pathway in salivary gland development

FEBS Journal ◽  
2019 ◽  
Vol 286 (18) ◽  
pp. 3701-3717
Author(s):  
Manabu Sakai ◽  
Moe Fukumoto ◽  
Kazuki Ikai ◽  
Hitomi Ono Minagi ◽  
Shinobu Inagaki ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Signalling Pathway ◽  
Gland Development ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

scholarly journals The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses

2015 ◽  
Vol 14 (1) ◽  
Author(s):  
Lifang Zhang ◽  
Jianhong Wu ◽  
Ming Tat Ling ◽  
Liang Zhao ◽  
Kong-Nan Zhao
Keyword(s):  
Human Papillomaviruses ◽  
Signalling Pathway ◽  
Human Cancers ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

scholarly journals A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling

2007 ◽  
Vol 403 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Greg M. Findlay ◽  
Lijun Yan ◽  
Julia Procter ◽  
Virginie Mieulet ◽  
Richard F. Lamb
Keyword(s):  
Amino Acids ◽  
Growth Factor ◽  
Cell Growth ◽  
Mammalian Target Of Rapamycin ◽  
Signalling Pathway ◽  
Initiation Factor ◽  
S6 Kinase ◽  
Eukaryotic Initiation Factor 4E ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

The mTOR (mammalian target of rapamycin) signalling pathway is a key regulator of cell growth and is controlled by growth factors and nutrients such as amino acids. Although signalling pathways from growth factor receptors to mTOR have been elucidated, the pathways mediating signalling by nutrients are poorly characterized. Through a screen for protein kinases active in the mTOR signalling pathway in Drosophila we have identified a Ste20 family member (MAP4K3) that is required for maximal S6K (S6 kinase)/4E-BP1 [eIF4E (eukaryotic initiation factor 4E)-binding protein 1] phosphorylation and regulates cell growth. Importantly, MAP4K3 activity is regulated by amino acids, but not the growth factor insulin and is not regulated by the mTORC1 inhibitor rapamycin. Our results therefore suggest a model whereby nutrients signal to mTORC1 via activation of MAP4K3.

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