scholarly journals Right Ventricular Pacing and Mechanical Dyssynchrony

Author(s):  
Kevin V. ◽  
Ryan M. ◽  
Alan J.

2013 ◽  
Vol 29 (4) ◽  
pp. 510-518 ◽  
Author(s):  
Didier Klug ◽  
Stephane Boule ◽  
Ludivine Wissocque ◽  
David Montaigne ◽  
Xavier Marechal ◽  
...  




Author(s):  
Lei Fan ◽  
Ravi Namani ◽  
Jenny S. Choy ◽  
Yousif Awakeem ◽  
Ghassan S. Kassab ◽  
...  

Mechanical dyssynchrony (MD) affects left ventricular (LV) mechanics and coronary perfusion. To understand the multifactorial effects of MD, we developed a computational model that bi-directionally couples the systemic circulation with the LV and coronary perfusion with flow regulation. In the model, coronary flow in the left anterior descending (LAD) and left circumflex (LCX) arteries affects the corresponding regional contractility based on a prescribed linear LV contractility-coronary flow relationship. The model is calibrated with experimental measurements of LV pressure and volume, as well as LAD and LCX flow rate waveforms acquired under regulated and fully dilated conditions from a swine under right atrial (RA) pacing. The calibrated model is applied to simulate MD. The model can simultaneously reproduce the reduction in mean LV pressure (39.3%), regulated flow (LAD: 7.9%; LCX 1.9%), LAD passive flow (21.6%) and increase in LCX passive flow (15.9%). These changes are associated with right ventricular pacing compared to RA pacing measured in the same swine only when LV contractility is affected by flow alterations with a slope of 1.4 mmHg/ml2 in a contractility-flow relationship. In sensitivity analyses, the model predicts that coronary flow reserve (CFR) decreases and increases in the LAD and LCX with increasing delay in LV free wall contraction. These findings suggest that asynchronous activation associated with MD impacts (1) the loading conditions that further affect the coronary flow, which may explain some of the changes in , and (2) the coronary flow that reduces global contractility, which contributes to the reduction in LV pressure.



2016 ◽  
Vol 32 (6) ◽  
pp. 830.e5-830.e6
Author(s):  
Pierre-Louis Nadeau ◽  
Jean Champagne ◽  
Franck Molin ◽  
Jean-François Sarrazin ◽  
Gilles O’Hara ◽  
...  


2021 ◽  
Vol 30 ◽  
pp. S256-S257
Author(s):  
R. O'Driscoll ◽  
Q. Yang ◽  
M. Zhu ◽  
G. McKay ◽  
R. Tan




2021 ◽  
Vol 14 (3) ◽  
pp. e242539
Author(s):  
Hammam Shereef ◽  
Ahmed Subahi ◽  
Mohit Pahuja ◽  
Luis Afonso


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