scholarly journals Paraquat: An Oxidative Stress Inducer

10.5772/32590 ◽  
2012 ◽  
Author(s):  
Ramiro Lascano ◽  
Nacira Munoz ◽  
German Robert ◽  
Marianela Rodriguez ◽  
Mariana Melchiorre ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oxidative Stress Inducer

Cadmium as oxidative stress inducer in brain of subacutely exposed rats and its implication on zinc level

2017 ◽  
Vol 280 ◽  
pp. S152
Author(s):  
Zorica Bulat ◽  
Marijana Curcic ◽  
Marko Antunovic ◽  
Slavica Vucinic ◽  
Aleksandra Buha Djordjevic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Zinc Level ◽  
Oxidative Stress Inducer

Abstract C11: The oxidative stress inducer elesclomol requires copper chelation for its anticancer activity

2009 ◽  
Author(s):  
Masazumi Nagai ◽  
Nha Vho ◽  
Elena Kostik ◽  
Suqin He ◽  
Jane Kepros ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Anticancer Activity ◽  
Copper Chelation ◽  
Oxidative Stress Inducer

Synthesis of Novel Selenocyanates and Evaluation of Their Effect in Cultured Mouse Neurons Submitted to Oxidative Stress

2020 ◽  
Author(s):  
Tiago Elias Allievi Frizon ◽  
José H. Cararo ◽  
Sumbal Saba ◽  
Gustavo C. Dal-Pont ◽  
Monique Michels ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Thiobarbituric Acid ◽  
Positive Control ◽  
Protein Carbonyl ◽  
Oxidative Challenge ◽  
Hydroxy Esters ◽  
Old Mice ◽  
Oxidative Stress Inducer

<p>Herein we report the synthesis of novel selenocyanates and assessment of their effect on the oxidative challenge elicited by hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) in cultured mouse neurons. First, <i>α</i>-methylene-<i>β</i>-hydroxy esters were prepared as precursors of allylic bromides. A reaction involving the generated bromides and sodium selenocyanate was conducted to produce the desired selenocyanates (<b>3a-f</b>). We next prepared cultures of neurons from 7-day-old-mice (<i>n </i>= 36). H<sub>2</sub>O<sub>2</sub> (10<sup>⁻5</sup> M) was added into the culture flasks as an oxidative stress inducer, alone or combined with one of each designed compounds. PhSe)<sub>2</sub> was used as positive control. It was carried out assessment of lipid (thiobarbituric acid reactive species, 4-hydroxy-2’-nonenal, 8-isoprostane), DNA (8-hydroxy-2’-deoxyguanosine) and protein (carbonyl) modification parameters. Finally, catalase and superoxide dismutase activities were also evaluated. Among the compounds, <b>3b</b>, <b>3d</b> and <b>3f</b> exhibited the most pronounced pattern of antioxidant activity, similar to (PhSe)<sub>2</sub>. These novel aromatic selenocyanates could be promising to be tried in most sophisticated <i>in vitro </i>studies or even at preclinical level.</p>

7002 ORAL Oxidative stress induction: an old idea whose time has come. MOA and clinical correlates of the oxidative stress inducer STA-478

2007 ◽  
Vol 5 (4) ◽  
pp. 396
Author(s):  
A. Williams ◽  
R. Gonzalez ◽  
D. Lawson ◽  
R. Weber ◽  
L. Hutchins ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Induction ◽  
Clinical Correlates ◽  
Oxidative Stress Inducer

scholarly journals Nitroxide TEMPO: A genotoxic and oxidative stress inducer in cultured cells

2013 ◽  
Vol 27 (5) ◽  
pp. 1496-1502 ◽  
Author(s):  
Xiaoqing Guo ◽  
Roberta A. Mittelstaedt ◽  
Lei Guo ◽  
Joseph G. Shaddock ◽  
Robert H. Heflich ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cultured Cells ◽  
And Oxidative Stress ◽  
Oxidative Stress Inducer

Apoptosis Provoked by the Oxidative Stress Inducer Menadione (Vitamin K3) Is Mediated by the Fas/Fas Ligand System

1999 ◽  
Vol 93 (1) ◽  
pp. 65-74 ◽  
Author(s):  
Roberto Caricchio ◽  
Dmitri Kovalenko ◽  
William K. Kaufmann ◽  
Philip L. Cohen
Keyword(s):  
Oxidative Stress ◽  
Fas Ligand ◽  
Vitamin K3 ◽  
Ligand System ◽  
Oxidative Stress Inducer

scholarly journals Synthesis of Novel Selenocyanates and Evaluation of Their Effect in Cultured Mouse Neurons Submitted to Oxidative Stress

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Tiago E. A. Frizon ◽  
José H. Cararo ◽  
Sumbal Saba ◽  
Gustavo C. Dal-Pont ◽  
Monique Michels ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Thiobarbituric Acid ◽  
Positive Control ◽  
Protein Carbonyl ◽  
Oxidative Challenge ◽  
Hydroxy Esters ◽  
Old Mice ◽  
Oxidative Stress Inducer

Herein, we report the synthesis of novel selenocyanates and assessment of their effect on the oxidative challenge elicited by hydrogen peroxide (H2O2) in cultured mouse neurons. First, α-methylene-β-hydroxy esters were prepared as precursors of allylic bromides. A reaction involving the generated bromides and sodium selenocyanate was conducted to produce the desired selenocyanates (3a-f). We next prepared cultures of neurons from 7-day-old mice (n=36). H2O2 (10-5 M) was added into the culture flasks as an oxidative stress inducer, alone or combined with one of each designed compounds. (PhSe)2 was used as a positive control. It was carried out assessment of lipid (thiobarbituric acid reactive species, 4-hydroxy-2′-nonenal, 8-isoprostane), DNA (8-hydroxy-2′-deoxyguanosine), and protein (carbonyl) modification parameters. Finally, catalase and superoxide dismutase activities were also evaluated. Among the compounds, 3b, 3d, and 3f exhibited the most pronounced pattern of antioxidant activity, similar to (PhSe)2. These novel aromatic selenocyanates could be promising to be tried in most sophisticated in vitro studies or even at the preclinical level.

scholarly journals Intracellular Oxidative Stress Levels are Significantly Associated with the Green Autofluorescence Intensity of Buthionine Sulfoximine-Treated B16-F10 Cells

2021 ◽  
Author(s):  
Wanzhi Tang ◽  
Weihai Ying
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Buthionine Sulfoximine ◽  
The Body ◽  
Skin Cells ◽  
Non Invasive ◽  
Skin Cell ◽  
Intracellular Ros ◽  
Intracellular Oxidative Stress ◽  
Oxidative Stress Inducer

AbstractSince oxidative stress is a critical common pathological factor of numerous diseases, it is critical to find biomarkers for non-invasive evaluations of the levels of oxidative stress in the body. Our previous studies have indicated that epidermal green autofluorescence (AF) is a novel biomarker of this type: The oxidative stress inducer buthionine sulfoximine (BSO) can dose-dependently increase the epidermal green AF of mice, with BSO doses being significantly associated with the AF intensity. However, it is necessary to use skin cell cultures to investigate the mechanisms underlying the relationships between BSO and the green AF intensity. In our current study we found that BSO concentration-dependently increased the green AF intensity of B16-F10 cells a skin cell line, with BSO concentrations being significantly associated with the AF intensity. BSO also concentration-dependently increased the intracellular DCF signals an index of ROS levels. The green AF intensity of the cells was also significantly associated with the intracellular ROS levels. Moreover, we found that the green AF intensity was significantly associated with the cell death induced by BSO. Collectively, our study has provided first evidence indicating that the green AF intensity of skin cells is significantly associated with both intracellular ROS levels and cell death of the skin cells exposed to oxidative stress, which has indicated that green AF is a novel biomarker for both oxidative stress and cell death.

scholarly journals Synthesis of Novel Selenocyanates and Evaluation of Their Effect in Cultured Mouse Neurons Submitted to Oxidative Stress

2020 ◽  
Author(s):  
Tiago Elias Allievi Frizon ◽  
José H. Cararo ◽  
Sumbal Saba ◽  
Gustavo C. Dal-Pont ◽  
Monique Michels ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Thiobarbituric Acid ◽  
Positive Control ◽  
Protein Carbonyl ◽  
Oxidative Challenge ◽  
Hydroxy Esters ◽  
Old Mice ◽  
Oxidative Stress Inducer

<p>Herein we report the synthesis of novel selenocyanates and assessment of their effect on the oxidative challenge elicited by hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) in cultured mouse neurons. First, <i>α</i>-methylene-<i>β</i>-hydroxy esters were prepared as precursors of allylic bromides. A reaction involving the generated bromides and sodium selenocyanate was conducted to produce the desired selenocyanates (<b>3a-f</b>). We next prepared cultures of neurons from 7-day-old-mice (<i>n </i>= 36). H<sub>2</sub>O<sub>2</sub> (10<sup>⁻5</sup> M) was added into the culture flasks as an oxidative stress inducer, alone or combined with one of each designed compounds. PhSe)<sub>2</sub> was used as positive control. It was carried out assessment of lipid (thiobarbituric acid reactive species, 4-hydroxy-2’-nonenal, 8-isoprostane), DNA (8-hydroxy-2’-deoxyguanosine) and protein (carbonyl) modification parameters. Finally, catalase and superoxide dismutase activities were also evaluated. Among the compounds, <b>3b</b>, <b>3d</b> and <b>3f</b> exhibited the most pronounced pattern of antioxidant activity, similar to (PhSe)<sub>2</sub>. These novel aromatic selenocyanates could be promising to be tried in most sophisticated <i>in vitro </i>studies or even at preclinical level.</p>

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