scholarly journals The Genotoxic Potential of Novel Materials Used in Modern Hip Replacements for Young Patients

10.5772/32656 ◽  
2012 ◽  
Author(s):  
Aikaterini Tsaousi

2003 ◽  
Vol 13 (2) ◽  
pp. 65-73
Author(s):  
M. Katsimihas ◽  
G. Katsimihas ◽  
M.B Lee ◽  
I. D. Learmonth

The clinical and radiographic features of 109 consecutive hybrid total hip replacements performed between 1986 and 1992 in 96 patients were retrospectively reviewed. A cementless Harris-Galante (HGP1) cup and a 32mm monobloc straight Muller stem were used in all cases. At an average 10.11 (range 5 to 15) years following surgery, the excellent durability of fixation of the Harris-Galante cup has been demonstrated with only one cup (0.9%) revised for periacetabular osteolysis and aseptic loosening. The prevalence of polyethylene wear was 27.4%. The mean annual linear wear rate was 0.063mm (range 0.00–0.53mm). There was a significantly increased wear of polyethylene inserts with an outer diameter < 52mm (<10mm polyethylene thickness), (ANOVA Test). However, there was no association found between acetabular liner wear and the following factors: underlying diagnosis, Charnley grade, age, weight and sex of the patient. The Harris Hip Score ranged between 5 and 54 pre-operatively and the average HHS was more than 80 post-operatively with more than 70% of patients pain-free. A liner with a thickness of 10mm or greater may prove beneficial in the prevention and reduction of wear rate particularly in young patients. It is recommended that all patients with this cup design, in which a polyethylene insert that is less than 10mm thick is coupled with a 32mm head, should continue to be regularly followed up.



2003 ◽  
Vol 13 (2_suppl) ◽  
pp. 31-35 ◽  
Author(s):  
J. Fisher ◽  
E. Ingham ◽  
M.H. Stone

There is now considerable clinical concern about the effect of polyethylene wear debris induced osteolysis in long term failure of hip replacements. This paper compares the wear of stabilised and crosslinked polyethylene to alternative hard on hard bearings. The volumetric wear rates of stabilised and moderately crosslinked polyethylene 50 to 35 mm3/million cycles were less than previously reported for historical gamma irradiated in air polyethylene, but still of a level that in the long term could cause osteolysis. The moderately crosslinked polyethylene produced less wear than non-crosslinked polyethylene, but particles were smaller and more reactive resulting in little change in the osteolytic potential. Alumina ceramic on ceramic produced substantially less wear and osteolytic potential. Metal on metal also produced less wear than polyethylene but the particles adversely influence cell viability.



2014 ◽  
Vol 89 ◽  
pp. 10-20
Author(s):  
Enrico Ciulli ◽  
Francesca Di Puccio ◽  
Lorenza Mattei ◽  
Santina Battaglia ◽  
Saverio Affatato

Since 1960, when the first hip prosthesis was introduced, up to now, several implant typologies have been proposed trying to meet the increasing clinical demands of more and more active and young patients. A substantial evolution of implant design has been occurring, both in terms of materials and geometry, basically driven by their tribological performances. Indeed, the main concern of hip implants consists in the release of wear debris, which can lead to implant loosening and failure. Thus, many studies on wear and lubrication of hip prostheses have been published in the last 15 years, mainly focused on experimental researches but also on numerical/modeling approaches. The aim of this work is to review the history of hip implants from a tribological point of view with a focus on ceramic-on-ceramic replacements, which represent the most advanced solution in terms of wear strength and chemical inertness. The main drawbacks of these implants, as the brittleness and the squeaking, are discussed and novel solutions examined.



2018 ◽  
Vol 23 (3) ◽  
Author(s):  
Anna Ogonowska ◽  
Sylwia Falkowska ◽  
Anna Oreszczuk ◽  
Katarzyna Sokołowska ◽  
Elżbieta Łuczaj-Cepowicz ◽  
...  

Introduction. The introduction of self-adhesive materials in dentistry has significantly reduced the duration of filling carious cavities. This group includes a light-curing, semi-liquid composite material from Kerr, called Vertise Flow. Aim. The aim of the study was clinical evaluation of restorations made using Vertise Flow in class I cavities in permanent teeth. Material and methods. In children aged 8-17 years, 154 cavities were filled with Vertise Flow. After 2 years, 49 fillings were clinically evaluated according to the modified Ryge’s criteria. The anatomical shape, colour, smoothness, marginal integrity of restorations and the evidence of secondary caries were assessed. Parents or legal guardians of the children consented to the medical procedures. Results. All the evaluated restorations were found retained, with acceptable anatomical shape and smoothness. One restoration slightly changed the colour, and unacceptable marginal integrity was seen in 2 cases. Secondary caries involved 2 teeth. Conclusions. In this 2-year observation, Vertise Flow meets the requirements for materials used for filling minimally prepared class I carious cavities in permanent teeth of young patients.



1996 ◽  
Vol 6 (3) ◽  
pp. 106-111
Author(s):  
O. Masbah ◽  
S.P.F. Hughes

We reviewed 33 primary total hip replacements in 24 patients younger than 50 years old. The mean age was 39.5 years and the follow-up averaged 6.1 years. There were 15 men and 9 women. Twenty-five hip replacements were cemented and 8 were uncemented. The most common hip pathology was osteonecrosis of the femoral head (36%), followed by rheumatoid arthritis (27%) and osteoarthritis (21%). Good pain relief was obtained in 70% of hips. Thigh pain developed in 2 uncemented hips and another had increasing hip pain. Function was good in 64% and 67% had good hip mobility. The best results were obtained in osteonecrosis of the femoral head, followed by osteoarthritis and rheumatoid arthritis. The commonest indication for revision was loosening of the acetabular component. Survival analysis of the 25 cemented hips showed a failure of 35% at 6 years and 9.1% at 8 years. Total hip replacement in young patients provides good pain relief and function although there is a limited time expectancy for good results.



2009 ◽  
Vol 24 (2) ◽  
pp. e77 ◽  
Author(s):  
David Ayers ◽  
Peyton Hays ◽  
Mark Eskander ◽  
Daniel Osuch ◽  
Henrik Malchau ◽  
...  


2021 ◽  
pp. 68-76
Author(s):  
Paulina Zygadło ◽  
◽  
Aneta Lewkowicz ◽  

1,8-diazafluoren-9-one (DFO) is a sensitive luminescent probe targeting α-amino acids. The study described herein exploited its physicochemical properties to form DFO/PVA polymer films. As a result, materials with stable and reactive DFO were obtained. Spectroscopic analysis of the formed films showed that the films with the highest concentration of DFO exhibited the highest reactivity. Novel materials in the form of thin DFO/PVA films with potential applications for revealing fingerprints on non-porous surfaces were obtained.



2020 ◽  
Vol 11 (1) ◽  
pp. 28-35
Author(s):  
Aayush Kumar Choudhary ◽  
Godwin Glivin ◽  
N. Kalaiselvan ◽  
V. Mariappan ◽  
S. Joseph Sekhar




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