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As a phosphorus scaffold, hexachlorocyclotriphosphazene (HCCP) is widely used for synthesis of varieties of derivatives,
including metal-binding complexes and several unique organometallic compounds, which exhibit potential catalytic,
flame retardant and biological activities. Some metal-binding HCCP derivatives have shown antibacterial activities as
free ligands and metal complexes. These derivatives can also serve as building blocks for the formation of antibacterial metal-
containing polymers. This mini-review is focused on the design and development of HCCP derivatives as potential antibacterial
agents with representative examples from recent years, as well as antibacterial mechanisms are also pointed out.
Metal Complexes as Prospective Antibacterial Agents
