2-Methoxy-5-(6-methoxypyridin-3-yl-imino-methyl)phenol and its transition metal complexes as potent antibacterial agents: Synthesis, characterization, theoretical investigations and biological evaluation

New series of copper (II), cobalt (II), zinc (II), nickel (II), manganese (II), iron (II) complexes of a novel Schiff base were prepared by the condensation of sulphadizine and pyridoxal hydrochloride. The ligand and metal complexes were characterized by utilizing different instrumental procedures like microanalysis, thermogravimetric examination and spectroscopy. The integrated ligand and transition metal complexes were screened against various bacteria and fungus. The studies demonstrated the enhanced activity of metal complexes against reported microbes when compared with free ligand.

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Synthesis, Characterization and Biological Evaluation of Transition Metal Complexes Derived from N, S Bidentate Ligands

International Journal of Molecular Sciences ◽

10.3390/ijms160511034 ◽

2015 ◽

Vol 16 (12) ◽

pp. 11034-11054 ◽

Cited By ~ 25

Author(s):

Enis Md Yusof ◽

Thahira Ravoof ◽

Edward Tiekink ◽

Abhimanyu Veerakumarasivam ◽

Karen Crouse ◽

...

Keyword(s):

Transition Metal ◽

Metal Complexes ◽

Transition Metal Complexes ◽

Biological Evaluation ◽

Bidentate Ligands

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Sulfonamide-derived compounds and their transition metal complexes: synthesis, biological evaluation and X-ray structure of 4-bromo-2-[(E)-{4-[(3,4-dimethylisoxazol-5 yl)sulfamoyl]phenyl} iminiomethyl] phenolate

Applied Organometallic Chemistry ◽

10.1002/aoc.1807 ◽

2011 ◽

Vol 25 (8) ◽

pp. 591-600 ◽

Cited By ~ 12

Author(s):

Zahid H. Chohan ◽

Hazoor A. Shad

Keyword(s):

Transition Metal ◽

Metal Complexes ◽

Transition Metal Complexes ◽

Biological Evaluation ◽

X Ray

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Exploration of catecholase-like activity of a series of magnetically coupled transition metal complexes of Mn, Co and Ni: new insights into the solution state behavior of Mn complexes

Dalton Transactions ◽

10.1039/c9dt02399b ◽

2019 ◽

Vol 48 (37) ◽

pp. 14164-14177 ◽

Cited By ~ 4

Author(s):

Abani Sarkar ◽

Aratrika Chakraborty ◽

Amit Adhikary ◽

Suvendu Maity ◽

Arnab Mandal ◽

...

Keyword(s):

Schiff Base ◽

Transition Metal ◽

Metal Complexes ◽

Oxidation State ◽

Transition Metal Complexes ◽

Schiff Base Complex ◽

State Behavior ◽

Base Complex ◽

State Dependent ◽

Theoretical Investigations

Oxidation state dependent catecholase activity has been explored with Mn-Schiff-base complex which transform oxidation state from +ii to +iii in solution with time by combined experimental and theoretical investigations.

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Synthesis, Characterization and Biological Evaluation of Schiff Base Transition Metal Complexes Derived from 4-Nitrobenzene-1,2-diamine and 5-Chloroisatin

Asian Journal of Chemistry ◽

10.14233/ajchem.2020.22724 ◽

2020 ◽

Vol 32 (9) ◽

pp. 2324-2328

Author(s):

NETRA PAL SINGH ◽

KAUSHAL KUMAR ◽

GAJENDRA KUMAR ◽

ANUROOP KUMAR

Keyword(s):

Schiff Base ◽

Transition Metal ◽

Metal Complexes ◽

Transition Metal Complexes ◽

Magnetic Moments ◽

Biological Evaluation ◽

Molar Conductance ◽

Spectral Studies ◽

Mass Spectral ◽

Bacteria And Fungi

A series of transition metal complexes of the type [MLX2], where M = Mn(II), Fe(II), Co(II), Ni(II), X = Cl–/CH3COO– and L = Schiff base derived from 4-nitrobenzene-1,2-diamine and 5-chloroisatin have been synthesized and characterized by elemental analysis, molar conductance, IR, UV-visible, magnetic moments measurement, 1H & 13C NMR and mass spectral studies. On the basis of physico-chemical studies and spectral evaluation, an octahedral geometry have been proposed for all metal(II) complexes. The antimicrobial activity of ligand and its metal complexes have been additionally screened against bacteria and fungi. Metal(II) complexes show good activity as compared to ligand towards studied microorganisms and also metal complexes checked for their catalytic properties for benzoylation of phenol.

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